Search Results - "Li, Ji Liang"

M2 macrophages mediate sorafenib resistance by secreting HGF in a feed-forward manner in hepatocellular carcinoma by Dong, Ningning, Shi, Xiangyi, Wang, Suihai, Gao, Yanjun, Kuang, Zhenzhan, Xie, Qian, Li, Yonglong, Deng, Huan, Wu, Yingsong, Li, Ming, Li, Ji-Liang

“…Background Sorafenib is the only approved first line systemic therapy for advanced hepatocellular carcinoma (HCC) in the last decade. Tumour resistance to…”
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Epstein–Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma by Cai, Longmei, Ye, Yanfen, Jiang, Qiang, Chen, Yuxiang, Lyu, Xiaoming, Li, Jinbang, Wang, Shuang, Liu, Tengfei, Cai, Hongbing, Yao, Kaitai, Li, Ji-Liang, Li, Xin

“…Epstein–Barr virus (EBV), aetiologically linked to nasopharyngeal carcinoma (NPC), is the first human virus found to encode many miRNAs. However, how these…”
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Tspan5 promotes epithelial–mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling by Xie, Qian, Guo, Huiling, He, Peirong, Deng, Huan, Gao, Yanjun, Dong, Ningning, Niu, Wenbo, Liu, Tiancai, Li, Ming, Wang, Suihai, Wu, Yingsong, Li, Ji‐Liang

“…Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to a high rate of tumour metastasis and disease recurrence. In physiological…”
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Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation by Bensaad, Karim, Favaro, Elena, Lewis, Caroline A, Peck, Barrie, Lord, Simon, Collins, Jennifer M, Pinnick, Katherine E, Wigfield, Simon, Buffa, Francesca M, Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J O, Karpe, Fredrik, Schulze, Almut, Harris, Adrian L

“…An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3)…”
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RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathway by Wang, Suihai, Wang, Xiaobo, Gao, Yanjun, Peng, Yingxia, Dong, Ningning, Xie, Qian, Zhang, Xian, Wu, Yingsong, Li, Ming, Li, Ji‐Liang

“…RN181, a RING finger domain‐containing protein, is an E3 ubiquitin ligase. However, its biological function and clinical significance in cancer biology are…”
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MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU by Favaro, Elena, Ramachandran, Anassuya, McCormick, Robert, Gee, Harriet, Blancher, Christine, Crosby, Meredith, Devlin, Cecilia, Blick, Christopher, Buffa, Francesca, Li, Ji-Liang, Vojnovic, Borivoj, Pires das Neves, Ricardo, Glazer, Peter, Iborra, Francisco, Ivan, Mircea, Ragoussis, Jiannis, Harris, Adrian L

“…Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor…”
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Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells by Favaro, Elena, Bensaad, Karim, Chong, Mei G., Tennant, Daniel A., Ferguson, David J.P., Snell, Cameron, Steers, Graham, Turley, Helen, Li, Ji-Liang, Günther, Ulrich L., Buffa, Francesca M., McIntyre, Alan, Harris, Adrian L.

“…Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment…”
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Rationally Designed Enzyme‐Resistant Peptidic Assemblies for Plasma Membrane Targeting in Cancer Treatment by Zhang, Shijin, Gong, Xuewen, Wei, Qinchuan, Lv, Jiarong, Du, Enming, Wang, Jiaqing, Ji, Wei, Li, Ji‐Liang

“…Peptides are being increasingly important for subcellular targeted cancer treatment to improve specificity and reverse multidrug resistance. However, there has…”
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Olfactomedin-like 3: possible functions in embryonic development and tumorigenesis by Jin, Ying, Li, Ji-Liang

“…Modern medical research has proven that human diseases are directly or indirectly related to genes. At the same time, genetic research has also brought updates…”
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Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth by McIntyre, Alan, Hulikova, Alzbeta, Ledaki, Ioanna, Snell, Cameron, Singleton, Dean, Steers, Graham, Seden, Peter, Jones, Dylan, Bridges, Esther, Wigfield, Simon, Li, Ji-Liang, Russell, Angela, Swietach, Pawel, Harris, Adrian L

“…Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic…”
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RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain by Bridges, Esther, Sheldon, Helen, Kleibeuker, Esther, Ramberger, Evelyn, Zois, Christos, Barnard, Alun, Harjes, Ulrike, Li, Ji-Liang, Masiero, Massimo, MacLaren, Robert, Harris, Adrian

“…Angiogenesis, the formation of new blood vessels by endothelial cells, is a finely tuned process relying on the balance between promoting and repressing…”
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A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis by Masiero, Massimo, Simões, Filipa Costa, Han, Hee Dong, Snell, Cameron, Peterkin, Tessa, Bridges, Esther, Mangala, Lingegowda S., Wu, Sherry Yen-Yao, Pradeep, Sunila, Li, Demin, Han, Cheng, Dalton, Heather, Lopez-Berestein, Gabriel, Tuynman, Jurriaan B., Mortensen, Neil, Li, Ji-Liang, Patient, Roger, Sood, Anil K., Banham, Alison H., Harris, Adrian L., Buffa, Francesca M.

“…Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an…”
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DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo by LI, Ji-Liang, SAINSON, Richard C. A, WU, Herren, CHOWDHURY, Partha S, RUSSELL, Angela J, MONTGOMERY, Craig P, POULSOM, Richard, HARRIS, Adrian L, EIN OON, Chern, TURLEY, Helen, LEEK, Russell, SHELDON, Helen, BRIDGES, Esther, SHI, Wen, SNELL, Cameron, BOWDEN, Emma T

“…Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate…”
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Downregulation of Manic fringe impedes angiogenesis and cell migration of renal carcinoma by Cheng, Wei Kang, Oon, Chern Ein, Kaur, Gurjeet, Sainson, Richard C.A., Li, Ji-Liang

“…Clear cell renal cell carcinoma (ccRCC) is a highly angiogenic cancer. Manic fringe (MFng) is elevated in ccRCC compared to the normal kidney. However, its…”
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Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival by Pike, Luke R G, Singleton, Dean C, Buffa, Francesca, Abramczyk, Olga, Phadwal, Kanchan, Li, Ji-Liang, Simon, Anna Katharina, Murray, James T, Harris, Adrian L

“…Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells…”
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Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases by Yang, Jun, Ledaki, Ioanna, Turley, Helen, Gatter, Kevin C., Montero, Juan-Carlos Martinez, Li, Ji-Liang, Harris, Adrian L.

“…Eukaryotic chromatin is subject to multiple posttranslational histone modifications such as acetylation, methylation, phosphorylation, and ubiquitination…”
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Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function by Williams, Cassin Kimmel, Li, Ji-Liang, Murga, Matilde, Harris, Adrian L., Tosato, Giovanna

“…Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and…”
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Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function by PATEL, Nilay S, LI, Ji-Liang, GENERALI, Daniele, POULSOM, Richard, CRANSTON, David W, HARRIS, Adrian L

“…The Notch signaling pathway and the delta-like 4 ligand (DLL4) play key roles in embryonic vascular development. Many of the pathways involved in embryonic…”
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Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo by LI, Ji-Liang, SAINSON, Richard C. A, HARRIS, Adrian L, WEN SHI, LEEK, Russell, HARRINGTON, Laura S, PREUSSER, Matthias, BISWAS, Swethajit, TURLEY, Helen, HEIKAMP, Emily, HAINFELLNER, Johannes A

“…The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often…”
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Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma by Raval, Raju R., Lau, Kah Weng, Tran, Maxine G. B., Sowter, Heidi M., Mandriota, Stefano J., Li, Ji-Liang, Pugh, Christopher W., Maxwell, Patrick H., Harris, Adrian L., Ratcliffe, Peter J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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