Search Results - "Li, Huilin"
-
1
Structure of the ER membrane complex, a transmembrane-domain insertase
Published in Nature (London) (20-08-2020)“…The endoplasmic reticulum (ER) membrane complex (EMC) cooperates with the Sec61 translocon to co-translationally insert a transmembrane helix (TMH) of many…”
Get full text
Journal Article -
2
Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs)
Published in International journal of molecular sciences (22-11-2020)“…Class I histone deacetylases (HDACs) are promising targets for epigenetic therapies for a range of diseases such as cancers, inflammations, infections and…”
Get full text
Journal Article -
3
Shift in the microbial community composition of surface water and sediment along an urban river
Published in The Science of the total environment (15-06-2018)“…•Microbial community in the urban river exhibited spatial variations due to the joint influence of chemical variables•The microbial OTUs richness decreased in…”
Get full text
Journal Article -
4
Enantioselective Construction of All‐Carbon Quaternary Stereogenic Centers by Using Phosphine Catalysis
Published in Asian journal of organic chemistry (01-09-2017)“…The asymmetric construction of all‐carbon quaternary stereogenic centers represents one of the most‐challenging tasks in organic synthesis, and it has drawn…”
Get full text
Journal Article -
5
Joint Optimization Strategy of Computation Offloading and Resource Allocation in Multi-Access Edge Computing Environment
Published in IEEE transactions on vehicular technology (01-09-2020)“…In order to help user terminal devices (UTDs) efficiently handle computation-intensive and time-delay sensitive computing task, multi-access edge computing…”
Get full text
Journal Article -
6
The atomic structure of a eukaryotic oligosaccharyltransferase complex
Published in Nature (London) (15-03-2018)“…N -glycosylation is a ubiquitous modification of eukaryotic secretory and membrane-bound proteins; about 90% of glycoproteins are N -glycosylated. The reaction…”
Get full text
Journal Article -
7
Molecular mechanisms of eukaryotic origin initiation, replication fork progression, and chromatin maintenance
Published in Biochemical journal (30-09-2020)“…Eukaryotic DNA replication is a highly dynamic and tightly regulated process. Replication involves several dozens of replication proteins, including the…”
Get more information
Journal Article -
8
The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism
Published in BioEssays (01-03-2018)“…The eukaryotic helicase is an 11‐subunit machine containing an Mcm2‐7 motor ring that encircles DNA, Cdc45 and the GINS tetramer, referred to as CMG (Cdc45,…”
Get full text
Journal Article -
9
Lattice engineering through nanoparticle–DNA frameworks
Published in Nature materials (01-06-2016)“…Advances in self-assembly over the past decade have demonstrated that nano- and microscale particles can be organized into a large diversity of ordered…”
Get full text
Journal Article -
10
Biological function simulation in neuromorphic devices: from synapse and neuron to behavior
Published in Science and technology of advanced materials (31-12-2023)“…As the boom of data storage and processing, brain-inspired computing provides an effective approach to solve the current problem. Various emerging materials…”
Get full text
Journal Article -
11
Catalytic Enantioselective Aza-Piancatelli Rearrangement
Published in Angewandte Chemie International Edition (21-11-2016)“…An efficient organocatalytic enantioselective aza‐Piancatelli rearrangement is disclosed. The powerful process provides rapid access to valuable chiral…”
Get full text
Journal Article -
12
Structure and activation mechanism of the hexameric plasma membrane H+-ATPase
Published in Nature communications (08-11-2021)“…The S. cerevisiae plasma membrane H + -ATPase, Pma1, is a P3A-type ATPase and the primary protein component of the membrane compartment of Pma1 (MCP). Like…”
Get full text
Journal Article -
13
The Eukaryotic Replisome Goes Under the Microscope
Published in Current biology (21-03-2016)“…The machinery at the eukaryotic replication fork has seen many new structural advances using electron microscopy and crystallography. Recent structures of…”
Get full text
Journal Article -
14
A distinct contrast in the lithospheric structure and limited crustal flow across the northeastern Tibetan Plateau: Evidence from Vs and Vp/Vs imaging
Published in Tectonophysics (05-08-2022)“…The uplift mechanism and geodynamic model of the northeastern (NE) Tibetan Plateau remain controversial. Two competing models have been proposed for the uplift…”
Get full text
Journal Article -
15
A self-powered artificial retina perception system for image preprocessing based on photovoltaic devices and memristive arrays
Published in Nano energy (01-12-2020)“…Artificial retina perception system is significant to pattern recognition and visual function emulation. However, the recent artificial retina system is mainly…”
Get full text
Journal Article -
16
Ferroelectric polymers for non‐volatile memory devices: a review
Published in Polymer international (01-06-2020)“…Ferroelectric memories have attracted great attention for data storage, and ferroelectric polymers have been widely studied with the development of flexible…”
Get full text
Journal Article -
17
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Published in Science translational medicine (15-06-2016)“…Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and…”
Get more information
Journal Article -
18
Ordered three-dimensional nanomaterials using DNA-prescribed and valence-controlled material voxels
Published in Nature materials (01-07-2020)“…The ability to organize nanoscale objects into well-defined three-dimensional (3D) arrays can translate advances in nanoscale synthesis into targeted material…”
Get full text
Journal Article -
19
Structure of the eukaryotic protein O-mannosyltransferase Pmt1−Pmt2 complex
Published in Nature structural & molecular biology (01-08-2019)“…In eukaryotes, a nascent peptide entering the endoplasmic reticulum (ER) is scanned by two Sec61 translocon-associated large membrane machines for protein…”
Get full text
Journal Article -
20
How does the horizontal watershed ecological compensation mechanism effect regional economy? - a county level empirical study on Xin’an River basin, China
Published in Ecological indicators (01-09-2024)“…•An ideal HWEC should bring ecological, economic and social benefits simultaneous.•The first three rounds of HWEC in Xin ’an River have no economic benefit at…”
Get full text
Journal Article