Search Results - "Li, Heng"

Minimap2: pairwise alignment for nucleotide sequences by Li, Heng

“…Abstract Motivation Recent advances in sequencing technologies promise ultra-long reads of ∼100 kb in average, full-length mRNA or cDNA reads in high…”
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New strategies to improve minimap2 alignment accuracy by Li, Heng

“…Abstract Summary We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more…”
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Minimap and miniasm: fast mapping and de novo assembly for noisy long sequences by Li, Heng

“…Single Molecule Real-Time (SMRT) sequencing technology and Oxford Nanopore technologies (ONT) produce reads over 10 kb in length, which have enabled…”
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A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data by Li, Heng

“…Motivation: Most existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing…”
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BFC: correcting Illumina sequencing errors by Li, Heng

“…BFC is a free, fast and easy-to-use sequencing error corrector designed for Illumina short reads. It uses a non-greedy algorithm but still maintains a speed…”
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Tabix: fast retrieval of sequence features from generic TAB-delimited files by Li, Heng

“…Tabix is the first generic tool that indexes position sorted files in TAB-delimited formats such as GFF, BED, PSL, SAM and SQL export, and quickly retrieves…”
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Improving SNP discovery by base alignment quality by Li, Heng

“…I propose a new application of profile Hidden Markov Models in the area of SNP discovery from resequencing data, to greatly reduce false SNP calls caused by…”
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Toward better understanding of artifacts in variant calling from high-coverage samples by Li, Heng

“…Whole-genome high-coverage sequencing has been widely used for personal and cancer genomics as well as in various research areas. However, in the lack of an…”
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FermiKit: assembly-based variant calling for Illumina resequencing data by Li, Heng

“…FermiKit is a variant calling pipeline for Illumina whole-genome germline data. It de novo assembles short reads and then maps the assembly against a reference…”
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Tough Self‐Healing Elastomers by Molecular Enforced Integration of Covalent and Reversible Networks by Wu, Jinrong, Cai, Li‐Heng, Weitz, David A.

“…Self‐healing polymers crosslinked by solely reversible bonds are intrinsically weaker than common covalently crosslinked networks. Introducing covalent…”
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Invalidity of, and alternative to, the linear quadratic model as a predictive model for postirradiation cell survival by Li, Heng

“…The linear quadratic (LQ) model has been the dominant tool in preclinical radiobiological modeling of cell survival as a function of dose. However, as a…”
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Ultra‐High Performance Amorphous Ga2O3 Photodetector Arrays for Solar‐Blind Imaging by Qin, Yuan, Li, Li‐Heng, Yu, Zhaoan, Wu, Feihong, Dong, Danian, Guo, Wei, Zhang, Zhongfang, Yuan, Jun‐Hui, Xue, Kan‐Hao, Miao, Xiangshui, Long, Shibing

“…The growing demand for scalable solar‐blind image sensors with remarkable photosensitive properties has stimulated the research on more advanced solar‐blind…”
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Biological effectiveness and relative biological effectiveness of ion beams for in‐vitro cell irradiation by Li, Heng

“…Biological effectiveness and relative biological effectiveness are critical for proton and ion beam radiotherapy. However, the relationship between the two…”
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Exploring single-sample SNP and INDEL calling with whole-genome de novo assembly by Li, Heng

“…Eugene Myers in his string graph paper suggested that in a string graph or equivalently a unitig graph, any path spells a valid assembly. As a string/unitig…”
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Inference of human population history from individual whole-genome sequences by Li, Heng, Durbin, Richard

“…Human population in the genes The history of human population size is important to understanding human evolution. Heng Li and Richard Durbin use complete…”
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Fast and accurate long-read alignment with Burrows–Wheeler transform by Li, Heng, Durbin, Richard

“…Motivation: Many programs for aligning short sequencing reads to a reference genome have been developed in the last 2 years. Most of them are very efficient…”
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Fast and accurate short read alignment with Burrows–Wheeler transform by Li, Heng, Durbin, Richard

“…Motivation: The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment…”
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Evolutionary history of Coleoptera revealed by extensive sampling of genes and species by Zhang, Shao-Qian, Che, Li-Heng, Li, Yun, Dan Liang, Pang, Hong, Ślipiński, Adam, Zhang, Peng

“…Beetles (Coleoptera) are the most diverse and species-rich group of insects, and a robust, time-calibrated phylogeny is fundamental to understanding…”
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The design and construction of reference pangenome graphs with minigraph by Li, Heng, Feng, Xiaowen, Chu, Chong

“…The recent advances in sequencing technologies enable the assembly of individual genomes to the quality of the reference genome. How to integrate multiple…”
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Deep learning of subsurface flow via theory-guided neural network by Wang, Nanzhe, Zhang, Dongxiao, Chang, Haibin, Li, Heng

“…•TgNN model trained with data while being guided by theory of the underlying problem.•TgNN achieves better predictability, reliability, and generalizability…”
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