Search Results - "Li, Guo Min"

Mechanisms and functions of DNA mismatch repair by Li, Guo-Min

“…DNA mismatch repair （MMR） is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily…”
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ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade by Shen, Jianfeng, Ju, Zhenlin, Zhao, Wei, Wang, Lulu, Peng, Yang, Ge, Zhongqi, Nagel, Zachary D., Zou, Jun, Wang, Chen, Kapoor, Prabodh, Ma, Xiangyi, Ma, Ding, Liang, Jiyong, Song, Shumei, Liu, Jinsong, Samson, Leona D., Ajani, Jaffer A., Li, Guo-Min, Liang, Han, Shen, Xuetong, Mills, Gordon B., Peng, Guang

“…ARID1A (the AT-rich interaction domain 1A, also known as BAF250a ) is one of the most commonly mutated genes in cancer 1 , 2 . The majority of ARID1A mutations…”
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Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair by Ortega, Janice, Lee, Grace Sanghee, Gu, Liya, Yang, Wei, Li, Guo-Min

“…DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases in…”
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Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase by Yang, Shuang, Zheng, Xiangdong, Lu, Chao, Li, Guo-Min, Allis, C David, Li, Haitao

“…High-frequency point mutations of genes encoding histones have been identified recently as novel drivers in a number of tumors. Specifically, the H3K36M/I…”
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity by Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

“…Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as the major contributor to the high objective response…”
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Speech Emotion Recognition Based on Modified ReliefF by Li, Guo-Min, Liu, Na, Zhang, Jun-Ao

“…As the key of human–computer natural interaction, the research of emotion recognition is of great significance to the development of computer intelligence. In…”
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Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes by Yang, Jin-Kui, Lin, Shan-Shan, Ji, Xiu-Juan, Guo, Li-Min

“…Multiple organ damage in severe acute respiratory syndrome (SARS) patients is common; however, the pathogenesis remains controversial. This study was to…”
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A special issue on DNA damage responses and genome maintenance by Li, Guo-Min, Chen, David J, Mitra, Sankar, Turchi, John J

“…There is nothing more fundamental than the genome for the existence and maintenance of all living beings. The importance of the genome is increasingly…”
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Inhibition of HSP90α protects cultured neurons from oxygen‐glucose deprivation induced necroptosis by decreasing RIP3 expression by Wang, Zhen, Guo, Li‐min, Wang, Yong, Zhou, Hong‐kang, Wang, Shu‐chao, Chen, Dan, Huang, Ju‐fang, Xiong, Kun

“…Heat shock protein 90α (HSP90α) maintains cell stabilization and regulates cell death, respectively. Recent studies have shown that HSP90α is involved in…”
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DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability by Huang, Yaping, Lu, Changzheng, Wang, Hanzhi, Gu, Liya, Fu, Yang-Xin, Li, Guo-Min

“…Molecular chaperone HSP70s are attractive targets for cancer therapy, but their substrate broadness and functional non-specificity have limited their role in…”
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MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth by Wang, Yijie, Chen, Yan, Wang, Chenliang, Yang, Mingming, Wang, Yanan, Bao, Lei, Wang, Jennifer E., Kim, BongWoo, Chan, Kara Y., Xu, Weizhi, Capota, Emanuela, Ortega, Janice, Nijhawan, Deepak, Li, Guo-Min, Luo, Weibo, Wang, Yingfei

“…How cancer cells cope with high levels of replication stress during rapid proliferation is currently unclear. Here, we show that macrophage migration…”
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Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis by Ortega, Janice, Li, Jessie Y., Lee, Sanghee, Tong, Dan, Gu, Liya, Li, Guo-Min

“…Proliferating cell nuclear antigen (PCNA) plays essential roles in eukaryotic cells during DNA replication, DNA mismatch repair (MMR), and other events at the…”
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DNA mismatch repair in the context of chromatin by Huang, Yaping, Li, Guo-Min

“…DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers…”
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MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-κB1 by Guo, Li-Min, Pu, Yong, Han, Zhe, Liu, Tao, Li, Yi-Xuan, Liu, Min, Li, Xin, Tang, Hua

“…MicroRNAs are emerging as important regulators of cancer-related processes. Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer…”
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Graphene oxide as a hole extraction layer loaded on BiVO4 photoanode for highly efficient photoelectrochemical water splitting by Guo, Min-Li, Wan, Shi-Peng, Li, Cao-Long, Zhang, Kan

“…The tailor-made oxygen evolution catalysts (OECs) paired with photoanodes offer a path to promote water oxidation kinetics; however, the unsatisfied interface…”
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LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression by Zhao, Gang, Luo, Wen-Dong, Yuan, Yong, Lin, Feng, Guo, Li-Min, Ma, Jing-Jing, Chen, Han-Bo, Tang, Huang, Shu, Jun

“…Introduction Human umbilical cord blood-derived MSCs (hUC-MSCs) have the potential to differentiate into osteoblasts. This study investigated the function and…”
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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells by Pan, Feng, Wingo, Thomas S., Zhao, Zhigang, Gao, Rui, Makishima, Hideki, Qu, Guangbo, Lin, Li, Yu, Miao, Ortega, Janice R., Wang, Jiapeng, Nazha, Aziz, Chen, Li, Yao, Bing, Liu, Can, Chen, Shi, Weeks, Ophelia, Ni, Hongyu, Phillips, Brittany Lynn, Huang, Suming, Wang, Jianlong, He, Chuan, Li, Guo-Min, Radivoyevitch, Tomas, Aifantis, Iannis, Maciejewski, Jaroslaw P., Yang, Feng-Chun, Jin, Peng, Xu, Mingjiang

“…TET2 is a dioxygenase that catalyses multiple steps of 5-methylcytosine oxidation. Although TET2 mutations frequently occur in various types of haematological…”
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Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches by Pinto, Ricardo Mouro, Dragileva, Ella, Kirby, Andrew, Lloret, Alejandro, Lopez, Edith, St Claire, Jason, Panigrahi, Gagan B, Hou, Caixia, Holloway, Kim, Gillis, Tammy, Guide, Jolene R, Cohen, Paula E, Li, Guo-Min, Pearson, Christopher E, Daly, Mark J, Wheeler, Vanessa C

“…The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may…”
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Decorating wood flour/HDPE composites with wood veneers by Guo, Li‐Min, Wang, Wei‐Hong, Wang, Qing‐Wen, Yan, Ning

“…The low surface free energy makes wood plastic composites difficult to bond with traditional adhesives, such as urea formaldehyde resin (UF). This study…”
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Regulation of the transcription factor NF-κB1 by microRNA-9 in human gastric adenocarcinoma by Wan, Hai-Ying, Guo, Li-Min, Liu, Tao, Liu, Min, Li, Xin, Tang, Hua

“…Abstract Background MicroRNAs (miRNAs) are a new class of naturally occurring, small, non-coding RNAs that regulate protein-coding mRNAs by causing mRNA…”
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