Search Results - "Li, Geoffrey C"

Optimizing NMR fragment-based drug screening for membrane protein targets by Li, Geoffrey C., Castro, Manuel A., Ukwaththage, Thilini, Sanders, Charles R.

“…[Display omitted] •Generalizable NMR-based fragment screening protocols for membrane protein targets were developed in this work.•Conditions for NMR-based…”
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Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A by Olivieri, Cristina, Wang, Yingjie, Li, Geoffrey C, V S, Manu, Kim, Jonggul, Stultz, Benjamin R, Neibergall, Matthew, Porcelli, Fernando, Muretta, Joseph M, Thomas, David Dt, Gao, Jiali, Blumenthal, Donald K, Taylor, Susan S, Veglia, Gianluigi

“…In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically…”
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Ion mobility–mass spectrometry reveals the role of peripheral myelin protein dimers in peripheral neuropathy by Fantin, Sarah M., Parson, Kristine F., Yadav, Pramod, Juliano, Brock, Li, Geoffrey C., Sanders, Charles R., Ohi, Melanie D., Ruotolo, Brandon T.

“…Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently even in wild-type (WT) form, with only 20% of the WT protein…”
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How T118M peripheral myelin protein 22 predisposes humans to Charcot–Marie–Tooth disease by Stefanski, Katherine M., Li, Geoffrey C., Marinko, Justin T., Carter, Bruce D., Samuels, David C., Sanders, Charles R.

“…Data from gnomAD indicate that a missense mutation encoding the T118M variation in human peripheral myelin protein 22 (PMP22) is found in roughly one of every…”
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Reply to Record et al. “The role of PMP22 T118M in Charcot–Marie–Tooth disease remains unsolved” by Stefanski, Katherine M., Li, Geoffrey C., Marinko, Justin T., Carter, Bruce D., Samuels, David C., Sanders, Charles R.

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Genetic intolerance analysis as a tool for protein science by Li, Geoffrey C., Forster-Benson, Eliot T.C., Sanders, Charles R.

“…Recent advances in whole genome and exome sequencing have dramatically increased the database of human gene variations. There are now enough sequenced human…”
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Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors by Li, Geoffrey C, Srivastava, Atul K, Kim, Jonggul, Taylor, Susan S, Veglia, Gianluigi

“…Protein kinase A is a prototypical phosphoryl transferase, sharing its catalytic core (PKA-C) with the entire kinase family. PKA-C substrate recognition,…”
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Dodecyl-β-melibioside Detergent Micelles as a Medium for Membrane Proteins by Hutchison, James M, Lu, Zhenwei, Li, Geoffrey C, Travis, Benjamin, Mittal, Ritesh, Deatherage, Catherine L, Sanders, Charles R

“…There remains a need for new non-ionic detergents that are suitable for use in biochemical and biophysical studies of membrane proteins. Here we explore the…”
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ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy by Olivieri, Cristina, Li, Geoffrey C, Wang, Yingjie, V S, Manu, Walker, Caitlin, Kim, Jonggul, Camilloni, Carlo, De Simone, Alfonso, Vendruscolo, Michele, Bernlohr, David A, Taylor, Susan S, Veglia, Gianluigi

“…ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these…”
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