Search Results - "Li, Gaocai"

Mitochondrial quality control in intervertebral disc degeneration by Song, Yu, Lu, Saideng, Geng, Wen, Feng, Xiaobo, Luo, Rongjin, Li, Gaocai, Yang, Cao

“…Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the human lifespan that can increase the risk of low back pain. More…”
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The Proteolysis of ECM in Intervertebral Disc Degeneration by Liang, Huaizhen, Luo, Rongjing, Li, Gaocai, Zhang, Weifeng, Song, Yu, Yang, Cao

“…Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back…”
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A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration by Ma, Liang, Feng, Xiaobo, Liang, Hang, Wang, Kun, Song, Yu, Tan, Lei, Wang, Bingjin, Luo, Rongjin, Liao, Zhiwei, Li, Gaocai, Liu, Xiangmei, Wu, Shuilin, Yang, Cao

“…[Display omitted] After an osteosarcoma excision, recurrence, large bone defects, and soft tissue injury are significant challenges for clinicians…”
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Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis by Zhang, Weifeng, Li, Gaocai, Luo, Rongjin, Lei, Jie, Song, Yu, Wang, Bingjin, Ma, Liang, Liao, Zhiwei, Ke, Wencan, Liu, Hui, Hua, Wenbin, Zhao, Kangcheng, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Wang, Kun, Yang, Cao

“…Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD)…”
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Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy by Li, Gaocai, Song, Yu, Liao, Zhiwei, Wang, Kun, Luo, Rongjin, Lu, Saideng, Zhao, Kangcheng, Feng, Xiaobo, Liang, Hang, Ma, Liang, Wang, Bingjin, Ke, Wencan, Yin, Huipeng, Zhan, Shengfeng, Li, Shuai, Wu, Xinghuo, Zhang, Yukun, Yang, Cao

“…N6 methyladenosine (m 6 A) is one of the most prevalent epitranscriptomic modifications of mRNAs, and plays a critical role in various bioprocesses…”
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Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair by Zhang, Weifeng, Qin, Xuan, Li, Gaocai, Zhou, Xingyu, Li, Hongyang, Wu, Di, Song, Yu, Zhao, Kangcheng, Wang, Kun, Feng, Xiaobo, Tan, Lei, Wang, Bingjin, Sun, Xuhui, Wen, Zhen, Yang, Cao

“…Excessive exercise is an etiological factor of intervertebral disc degeneration (IVDD). Engineered extracellular vesicles (EVs) exhibit excellent therapeutic…”
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O-GlcNAc transferase regulates intervertebral disc degeneration by targeting FAM134B-mediated ER-phagy by Luo, Rongjin, Li, Gaocai, Zhang, Weifei, Liang, Huaizhen, Lu, Saideng, Cheung, Jason Pui Yin, Zhang, Teng, Tu, Ji, Liu, Hui, Liao, Zhiwei, Ke, Wencan, Wang, Bingjin, Song, Yu, Yang, Cao

“…Both O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and endoplasmic reticulum-phagy (ER-phagy) are well-characterized conserved adaptive regulatory…”
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Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration by Ke, Wencan, Wang, Bingjin, Liao, Zhiwei, Song, Yu, Li, Gaocai, Ma, Liang, Wang, Kun, Li, Shuai, Hua, Wenbin, Yang, Cao

“…Abstract Background Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer,…”
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Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation by Li, Gaocai, Zhu, Qianqian, Wang, Bingjin, Luo, Rongjin, Xiao, Xiaohui, Zhang, Yi, Ma, Liang, Feng, Xiaobo, Huang, Jingang, Sun, Xuhui, Wen, Zhen, Pan, Yue, Yang, Cao

“…Stem cell senescence contributes to stem cell exhaustion and drives various aging‐associated disorders. However, strategies to rejuvenate senescent stem cells…”
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An approach for traffic pattern recognition integration of ship AIS data and port geospatial features by Li, Gaocai, Zhang, Xinyu, Jiang, Lingling, Wang, Chengbo, Huang, Ruining, Liu, Zhensheng

“…Recognition of ship traffic patterns can provide insights into the rules of navigation, maneuvering, and collision avoidance for ships at sea. This is…”
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Author Correction: WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration by Li, Gaocai, Ma, Liang, He, Shujie, Luo, Rongjin, Wang, Bingjin, Zhang, Weifeng, Song, Yu, Liao, Zhiwei, Ke, Wencan, Xiang, Qian, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Wang, Kun, Yang, Cao

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WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration by Li, Gaocai, Ma, Liang, He, Shujie, Luo, Rongjin, Wang, Bingjin, Zhang, Weifeng, Song, Yu, Liao, Zhiwei, Ke, Wencan, Xiang, Qian, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Wang, Kun, Yang, Cao

“…N6-methyladenosine (m 6 A) is the most prevalent RNA modification at the posttranscriptional level and involved in various diseases and cellular processes…”
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Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities by Luo, Rongjin, Chang, Yanmin, Liang, Huaizhen, Zhang, Weifeng, Song, Yu, Li, Gaocai, Yang, Cao

“…In recent decades, accumulating research on the interactions between microbiome homeostasis and host health has broadened new frontiers in delineating the…”
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Biomimetic bone-periosteum scaffold for spatiotemporal regulated innervated bone regeneration and therapy of osteosarcoma by Xu, Yan, Xu, Chao, Song, Huan, Feng, Xiaobo, Ma, Liang, Zhang, Xiaoguang, Li, Gaocai, Mu, Congpu, Tan, Lei, Zhang, Zhengdong, Liu, Zhongyuan, Luo, Zhiqiang, Yang, Cao

“…The complexity of repairing large segment defects and eradicating residual tumor cell puts the osteosarcoma clinical management challenging. Current…”
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Osteointegration of 3D-Printed Fully Porous Polyetheretherketone Scaffolds with Different Pore Sizes by Feng, Xiaobo, Ma, Liang, Liang, Hang, Liu, Xiaoming, Lei, Jie, Li, Wenqiang, Wang, Kun, Song, Yu, Wang, Bingjin, Li, Gaocai, Li, Shuai, Yang, Cao

“…Polyetheretherketone (PEEK) constitutes a preferred alternative material for orthopedic implants owing to its good mechanical properties and biocompatibility…”
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Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells by Ma, Liang, Li, Gaocai, Wang, Kun, Song, Yu, Li, Shuai, Wu, Xinghuo, Yang, Cao, Zhang, Yukun, Liao, Zhiwei, Wang, Bingjin, Luo, Rongjin, Hua, Wenbin, Feng, Xiaobo, Wang, Juntan, Cheng, Zhangrong, Xiang, Qian, Lu, Saideng

“…Intervertebral disc degeneration (IDD) is one of the most common chronic degenerative musculoskeletal disorders. Oxidative stress-induced apoptosis of the…”
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m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency by Li, Gaocai, Luo, Rongjin, Zhang, Weifeng, He, Shujie, Wang, Bingjin, Liang, Huaizhen, Song, Yu, Ke, Wencan, Shi, Yunsong, Feng, Xiaobo, Zhao, Kangcheng, Wu, Xinghuo, Zhang, Yukun, Wang, Kun, Yang, Cao

“…Background The intervertebral disc (IVD) degeneration is the leading cause of low back pain, which accounts for a main cause of disability. N6‐methyladenosine…”
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RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway by Luo, Rongjin, Liang, Huaizhen, Zhang, Weifeng, Li, Gaocai, Zhao, Kangcheng, Hua, Wenbin, Song, Yu, Yang, Cao

“…Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact…”
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Ship Anomalous Behavior Detection in Port Waterways Based on Text Similarity and Kernel Density Estimation by Li, Gaocai, Zhang, Xinyu, Shu, Yaqing, Wang, Chengbo, Guo, Wenqiang, Wang, Jiawei

“…The navigational safety of ships on waterways plays a crucial role in ensuring the operational efficiency of ports. Ship anomalous behavior detection is an…”
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Semantic Recognition of Ship Motion Patterns Entering and Leaving Port Based on Topic Model by Li, Gaocai, Liu, Mingzheng, Zhang, Xinyu, Wang, Chengbo, Lai, Kee-hung, Qian, Weihuachao

“…Recognition and understanding of ship motion patterns have excellent application value for ship navigation and maritime supervision, i.e., route planning and…”
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