Search Results - "Li, Fubin"

Inhibitory Fcγ Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies by Li, Fubin, Ravetch, Jeffrey V.

“…CD40, a member of the tumor necrosis factor receptor (TNFR) superfamily, is expressed on antigen-presenting cells (APCs) and is essential for immune…”
Get full text

Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo by Li, Fubin, Ravetch, Jeffrey V.

“…Agonistic anti-TNF receptor (TNFR) superfamily member antibodies are a class of promising antitumor therapies in active clinical investigation. An unexpected…”
Get full text

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement by Li, Fubin, Ravetch, Jeffrey V

“…By virtue of their ability to induce apoptosis and regulate growth, differentiation, and cytokine responses, the tumor necrosis factor receptor (TNFR)…”
Get full text

The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells by Chen, Xue, Xu, Yanyan, Chen, Qidi, Zhang, Heng, Zeng, Yu, Geng, Yan, Shen, Lei, Li, Fubin, Chen, Lei, Chen, Guo-Qiang, Huang, Chuanxin, Liu, Junling

“…Beyond a function in hemostasis and thrombosis, platelets can regulate innate and adaptive immune responses. Hyperactive platelets are frequently associated…”
Get full text

Mouse model recapitulating human Fcγ receptor structural and functional diversity by Smith, Patrick, DiLillo, David J, Bournazos, Stylianos, Li, Fubin, Ravetch, Jeffrey V

“…The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector…”
Get full text

Analysis of the effectiveness of virtual reality technology integration in landscape design by Li, Fubin, Zhao, Xia

“…In this paper, we first studied the 3D visual immersion technology of virtual reality, explored the stereoscopic display and multi-channel stereoscopic display…”
Get full text

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis by Georgoudaki, Anna-Maria, Prokopec, Kajsa E., Boura, Vanessa F., Hellqvist, Eva, Sohn, Silke, Östling, Jeanette, Dahan, Rony, Harris, Robert A., Rantalainen, Mattias, Klevebring, Daniel, Sund, Malin, Brage, Suzanne Egyhazi, Fuxe, Jonas, Rolny, Charlotte, Li, Fubin, Ravetch, Jeffrey V., Karlsson, Mikael C.I.

“…Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages…”
Get full text

Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus by Miao, Naijun, Wang, Zhuning, Wang, Qinlan, Xie, Hongyan, Yang, Ninghao, Wang, Yanzhe, Wang, Jin, Kang, Haixia, Bai, Wenjuan, Wang, Yuanyuan, He, Rui, Yan, Kepeng, Wang, Yang, Hu, Qiongyi, Liu, Zhaoyuan, Li, Fubin, Wang, Feng, Ginhoux, Florent, Zhang, Xiaoling, Yin, Jianyong, Lu, Limin, Wang, Jing

“…Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in systemic lupus erythematosus (SLE), the mechanisms leading to the…”
Get full text

Efficacy of damage control orthopedics strategy in the management of lower limb trauma by Li, Fubin, Gao, Lecai, Zuo, Jiangang, Wei, Jindong

“…Little is known about the efficacy of damage control (DC) surgery in the management of lower limb trauma. Here we compared the clinical parameters and…”
Get full text

Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility by Liu, Xiaobo, Zhao, Yingjie, Shi, Huan, Zhang, Yan, Yin, Xueying, Liu, Mingdong, Zhang, Huihui, He, Yongning, Lu, Boxun, Jin, Tengchuan, Li, Fubin

“…Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed…”
Get full text

Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response by Hu, Qianwen, Xu, Tingting, Zhang, Min, Zhang, Heng, Liu, Yongbo, Li, Hua-bing, Chen, Chiqi, Zheng, Junke, Zhang, Zhen, Li, Fubin, Shen, Nan, Zhang, Wenqian, Melnick, Ari, Huang, Chuanxin

“…During the early phase of primary humoral responses, activated B cells can differentiate into different types of effector cells, dependent on B cell receptor…”
Get full text

A general requirement for FcγRIIB co-engagement of agonistic anti-TNFR antibodies by Li, Fubin, Ravetch, Jeffrey V.

“…Comment on: Li F, et al. Proc Natl Acad Sci USA 2012; 109:10966-71…”
Get full text

In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation by Zhao, Rongqing, Zhang, Huihui, Zhang, Yan, Li, Dan, Huang, Chuanxin, Li, Fubin

“…Germinal center (GC) B cell differentiation is critical for the production of affinity-matured pathogen-specific antibodies, the dysregulation of which may…”
Get full text

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc by Li, Man, Lazorchak, Adam S., Ouyang, Xinxing, Zhang, Huihui, Liu, Hongzhi, Arojo, Omotooke A., Yan, Lichong, Jin, Jingsi, Han, Yuheng, Qu, Guojun, Fu, Yuhong, Xu, Xiaocao, Liu, Xiaobo, Zhang, Wenqian, Yang, Zhengfeng, Ruan, Chuan, Wang, Qijun, Liu, Dou, Huang, Chuanxin, Lu, Lu, Jiang, Shibo, Li, Fubin, Su, Bing

“…Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood…”
Get full text

Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases by Bi, Yanxia, Su, Jian, Zhou, Shengru, Zhao, Yingjie, Zhang, Yan, Zhang, Huihui, Liu, Mingdong, Zhou, Aiwu, Xu, Jianrong, Pan, Meng, Zhao, Yiming, Li, Fubin

“…IgG4 is the least potent human IgG subclass for the FcγR-mediated antibody effector function. Paradoxically, IgG4 is also the dominant IgG subclass of…”
Get full text

Lie symmetry analysis and conservation law for the equation arising from higher order Broer-Kaup equation by Wang, Hengtai, Chen, Huiwen, Ouyang, Zigen, Li, Fubin

“…In this paper, Lie symmetry analysis is performed for the equation derived from $(2+1)$-dimensional higher order Broer-Kaup equation. Meanwhile, the optimal…”
Get full text

Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites by Garrett, Francine E., Emelyanov, Alexander V., Sepulveda, Manuel A., Flanagan, Patrick, Volpi, Sabrina, Li, Fubin, Loukinov, Dmitry, Eckhardt, Laurel A., Lobanenkov, Victor V., Birshtein, Barbara K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses by Deng, Zihou, Ma, Shixin, Zhou, Hao, Zang, Aiping, Fang, Yiyuan, Li, Tiantian, Shi, Huanjing, Liu, Mei, Du, Min, Taylor, Patricia R, Zhu, Helen He, Chen, Jiangye, Meng, Guangxun, Li, Fubin, Chen, Changbin, Zhang, Yan, Jia, Xin-Ming, Lin, Xin, Zhang, Xiaoming, Pearlman, Eric, Li, Xiaoxia, Feng, Gen-Sheng, Xiao, Hui

“…Fungal infection induces signaling downstream C-type lectin receptors through the activation of the tyrosine kinase Syk. Xiao and colleagues show that the…”
Get full text

Drug therapy for chronic subdural hematoma: Bench to bedside by Fu, Shuanglin, Li, Fubin, Bie, Li

“…•CSDH is an inflammatory angiogenic diseases, surgery is the effective intervention for therapy of CSDH.•A better understanding of CSDH pathogenesis should…”
Get full text

Inhibitory Fcγ receptor is required for the maintenance of tolerance through distinct mechanisms by Li, Fubin, Smith, Patrick, Ravetch, Jeffrey V

“…The inhibitory FcγR FcγRIIB is widely expressed on B cells, dendritic cells (DCs), and myeloid effector cells and modulates a variety of Ab-driven in vivo…”
Get full text