Search Results - "Li, Cunxi"

Convergence between Wnt-β-catenin and EGFR signaling in cancer by Hu, Tianhui, Li, Cunxi

“…Wnt and EGFR signaling play key roles in embryonic development and cell proliferation. It is well documented that dysregulation of these two pathways often…”
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Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression by Liu, Hao, Li, Danxiu, Sun, Lina, Qin, Hongqiang, Fan, Ahui, Meng, Lingnan, Graves-Deal, Ramona, Glass, Sarah E, Franklin, Jeffrey L, Liu, Qi, Wang, Jing, Yeatman, Timothy J, Guo, Hao, Zong, Hong, Jin, Shuilin, Chen, Zhiyu, Deng, Ting, Fang, Ying, Li, Cunxi, Karijolich, John, Patton, James G, Wang, Xin, Nie, Yongzhan, Fan, Daiming, Coffey, Robert J, Zhao, Xiaodi, Lu, Yuanyuan

“…Abstract Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing…”
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A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer by Cao, Tianyu, Lu, Yuanyuan, Wang, Qi, Qin, Hongqiang, Li, Hongwei, Guo, Hao, Ge, Minghui, Glass, Sarah E, Singh, Bhuminder, Zhang, Wenyao, Dong, Jiaqiang, Du, Feng, Qian, Airong, Tian, Ye, Wang, Xin, Li, Cunxi, Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Coffey, Robert J, Zhao, Xiaodi

“…De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients…”
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Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells by Starchenko, Alina, Graves-Deal, Ramona, Yang, Yu-Ping, Li, Cunxi, Zent, Roy, Singh, Bhuminder, Coffey, Robert J

“…Apicobasolateral polarity is a fundamental property of epithelial cells, and its loss is a hallmark of cancer. Integrin-mediated contact with the extracellular…”
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Fibrocystin/Polyductin Modulates Renal Tubular Formation by Regulating Polycystin-2 Expression and Function by KIM, Ingyu, YULONG FU, GEORGE, Alfred L, COFFEY, Robert J, FENG, Zhong-Ping, GUANQING WU, HUI, Kwokyin, MOECKEL, Gilbert, WEIYI MAI, CUNXI LI, DAN LIANG, PING ZHAO, JIE MA, CHEN, Xing-Zhen

“…Autosomal recessive polycystic kidney disease is caused by mutations in PKHD1, which encodes the membrane-associated receptor-like protein…”
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Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates β-Catenin by KIM, Ingyu, TIANBING DING, JIE MA, PING ZHAO, COFFEY, Robert J, QIMIN ZHAN, GUANQING WU, YULONG FU, CUNXI LI, LAN CUI, AO LI, PEIWEN LIAN, DAN LIANG, WANG, Dao W, CAIYING GUO

“…Loss of polycystin-2 (PC2) in mice (Pkd2(-/-)) results in total body edema, focal hemorrhage, structural cardiac defects, abnormal left-right axis, hepatorenal…”
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Polycystin-2 Expression Is Regulated by a PC2-binding Domain in the Intracellular Portion of Fibrocystin by Kim, Ingyu, Li, Cunxi, Liang, Dan, Chen, Xing-Zhen, Coffy, Robert J., Ma, Jie, Zhao, Ping, Wu, Guanqing

“…Autosomal dominant (ADPKD) and autosomal recessive (ARPKD) polycystic kidney disease are caused by mutations in Pkd1/Pkd2 and Pkhd1, which encode polycystins…”
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Ginkgo biloba extract and Aspirin synergistically attenuate activated platelet-induced ROS production and LOX-1 expression in human coronary artery endothelial cells by Zhu, Xianguan, Li, Zhongdong, Li, Cunxi, Zhang, Jing, Zou, Zhikang, Wang, Jianchang

“…In the present study, we investigated whether the therapeutic dosages of Ginkgo biloba extract (EGb) and Aspirin (ASP) might synergistically suppress oxidative…”
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Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin by Van Raay, Terence J, Fortino, Nicholas J, Miller, Bryan W, Ma, Haiting, Lau, Garnet, Li, Cunxi, Franklin, Jeffery L, Attisano, Liliana, Solnica-Krezel, Lilianna, Coffey, Robert J

“…Cyto-nuclear shuttling of β-catenin is at the epicenter of the canonical Wnt pathway and mutations in genes that result in excessive nuclear accumulation of…”
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PKHD1 Protein Encoded by the Gene for Autosomal Recessive Polycystic Kidney Disease Associates with Basal Bodies and Primary Cilia in Renal Epithelial Cells by Zhang, Ming-Zhi, Mai, Weiyi, Li, Cunxi, Cho, Sae-youll, Hao, Chuanming, Moeckel, Gilbert, Zhao, Runxiang, Kim, Ingyu, Wang, Jikui, Xiong, Huaqi, Wang, Hong, Sato, Yasunori, Wu, Yizhong, Nakanuma, Yasuni, Lilova, Marusia, Pei, York, Harris, Raymond C., Li, Song, Coffey, Robert J., Sun, Le, Wu, Dianqing, Chen, Xing-Zhen, Breyer, Matthew D., Zhao, Zhizhuang Joe, McKanna, James A., Wu, Guanqing, Cohen, Stanley

“…Mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene have been shown to cause autosomal recessive polycystic kidney disease (ARPKD), but the…”
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Use of Fluorescence-activated Vesicle Sorting for Isolation of Naked2-associated, Basolaterally Targeted Exocytic Vesicles for Proteomics Analysis by Cao, Zheng, Li, Cunxi, Higginbotham, James N., Franklin, Jeffrey L., Tabb, David L., Graves-Deal, Ramona, Hill, Salisha, Cheek, Kristin, Jerome, W. Gray, Lapierre, Lynne A., Goldenring, James R., Ham, Amy-Joan L., Coffey, Robert J.

“…By interacting with the cytoplasmic tail of a Golgi-processed form of transforming growth factor-α (TGFα), Naked2 coats TGFα-containing exocytic vesicles and…”
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Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys by Hu, Bo, He, Xiusheng, Li, Ao, Qiu, Qingchao, Li, Cunxi, Liang, Dan, Zhao, Ping, Ma, Jie, Coffey, Robert J., Zhan, Qimin, Wu, Guanqing

“…Mutations in the PKHD1 gene result in autosomal recessive polycystic kidney disease (ARPKD) in humans. To determine the molecular mechanism of the cystogenesis…”
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Structural studies of human Naked2: A biologically active intrinsically unstructured protein by Hu, Tianhui, Krezel, Andrzej M., Li, Cunxi, Coffey, Robert J.

“…Naked1 and 2 are two mammalian orthologs of Naked Cuticle, a canonical Wnt signaling antagonist in Drosophila. Naked2, but not Naked1, interacts with…”
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EGF receptor-independent action of TGF-α protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation by Ding, Wei, Li, Cunxi, Hu, Tianhui, Graves-Deal, Ramona, Fotia, Andrew B, Weissman, Allan M, Coffey, Robert J

“…Naked family members (Drosophila Naked Cuticle and mammalian Naked1 and Naked2) have been identified as inducible antagonists of canonical Wnt signaling. We…”
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Myristoylated Naked2 Escorts Transforming Growth Factor α to the Basolateral Plasma Membrane of Polarized Epithelial Cells by Li, Cunxi, Franklin, Jeffrey L., Graves-Deal, Ramona, Jerome, W. Gray, Cao, Zheng, Coffey, Robert J., Scott, Matthew P.

“…The epidermal growth factor receptor ligands transforming growth factor α (TGFα) and amphiregulin are delivered to the basolateral surface of polarized…”
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lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling by Lu, Yuanyuan, Zhao, Xiaodi, Liu, Qi, Li, Cunxi, Graves-Deal, Ramona, Cao, Zheng, Singh, Bhuminder, Franklin, Jeffrey L, Wang, Jing, Hu, Huaying, Wei, Tianying, Yang, Mingli, Yeatman, Timothy J, Lee, Ethan, Saito-Diaz, Kenyi, Hinger, Scott, Patton, James G, Chung, Christine H, Emmrich, Stephan, Klusmann, Jan-Henning, Fan, Daiming, Coffey, Robert J

“…Concomitant overexpression of microRNAs miR-100 and miR-125b-1 within the host long non-coding RNA MIR100HG induces cetuximab resistance in cancer in the…”
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Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame by JINMING YANG, JING LUAN, YINGCHUN YU, CUNXI LI, DEPINHO, Ronald A, CHIN, Lynda, RICHMOND, Ann

“…The molecular and genetic events that contribute to the genesis and progression of cutaneous malignant melanoma are poorly understood, attributable in large…”
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Byr4 Localizes to Spindle-Pole Bodies in a Cell Cycle-regulated Manner to Control Cdc7 Localization and Septation in Fission Yeast by Li, Cunxi, Furge, Kyle A., Cheng, Qiu-chen, Albright, Charles F.

“…Cytokinesis and septation in the fission yeastSchizosaccharomyces pombe are studied as a model for mammalian cell division. In fission yeast, septation is…”
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Knowledge transfer accelerated turbine blade optimization via an sample-weighted variational autoencoder by Guo, Zhendong, Li, Cunxi, Chen, Yun, Song, Liming, Li, Jun, Feng, Zhenping

“…The aerodynamic shape optimization (ASO) of turbine blades is a typical expensive black-box problem. With the ever increasingly strict design requirements,…”
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Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells by Guo, Tongtong, Wang, Juan, Pang, Maogui, Liu, Wanning, Zhang, Xiaohui, Fan, Ahui, Liu, Hengtao, Liu, Qianqian, Wei, Tianying, Li, Cunxi, Zhao, Xiaodi, Lu, Yuanyuan

“…Significant advances have been made in reprogramming various somatic cells into induced pluripotent stem cells (iPSCs) and in multi-lineage differentiation…”
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