Search Results - "Li, Chunpu"

Rhodium(III)-Catalyzed C–H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides by Peng, Jingjing, Li, Chunpu, Khamrakulov, Mirzadavlat, Wang, Jiang, Liu, Hong

“…Maleimide is widely applied in many fields, especially in antibody–drug conjugations and peptide drugs. Herein, we develop a strategy for the C–H alkenylation…”
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease by Dai, Wenhao, Zhang, Bing, Jiang, Xia-Ming, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Peng, Jingjing, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, Lei-Ke, Xu, Yechun, Yang, Haitao, Liu, Hong

“…SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent responsible for the global COVID-19 (coronavirus disease 2019) outbreak…”
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Predictive models of radiographic progression and pain progression in patients with knee osteoarthritis: data from the FNIH OA biomarkers consortium project by Li, Xiaoyu, Li, Chunpu, Zhang, Peng

“…The progression of knee osteoarthritis (OA) can be defined as either radiographic progression or pain progression. This study aimed to construct models to…”
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Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies by Liang, Xuewu, Zang, Jie, Li, Xiaoyang, Tang, Shuai, Huang, Min, Geng, Meiyu, Chou, C. James, Li, Chunpu, Cao, Yichun, Xu, Wenfang, Liu, Hong, Zhang, Yingjie

“…Concurrent inhibition of Janus kinase (JAK) and histone deacetylase (HDAC) could potentially improve the efficacy of the HDAC inhibitors in the treatment of…”
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Sulfoximines-Assisted Rh(III)-Catalyzed C-H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature by Wang, Bao, Han, Xu, Li, Jian, Li, Chunpu, Liu, Hong

“…A mild and facile Cp*Rh(III)-catalyzed C-H activation and intramolecular cascade annulation protocol has been proposed for the furnishing of highly fused…”
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Rh(III)-Catalyzed Annulation of Boc-Protected Benzamides with Diazo Compounds: Approach to Isocoumarins by Dong, Guangyu, Li, Chunpu, Liu, Hong

“…A mild rhodium-catalyzed annulation of Boc-protected benzamides with diazo compounds via C-C/C-O bond formation has been explored. In the presence of…”
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Structure–Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors by Li, Chunpu, Su, Mingbo, Zhu, Wei, Kan, Weijuan, Ge, Tianpeng, Xu, Gaoya, Wang, Shuni, Sheng, Li, Gao, Feng, Ye, Yunfei, Wang, Jiang, Zhou, Yubo, Li, Jia, Liu, Hong

“…LSD1 is identified as an essential drug target, which is closely correlated to the development of several tumor types. In this work, on the basis of…”
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γ-AApeptides–based Small Molecule Ligands That Disaggregate Human Islet Amyloid Polypeptide by Bolarinwa, Olapeju, Li, Chunpu, Khadka, Nawal, Li, Qi, Wang, Yan, Pan, Jianjun, Cai, Jianfeng

“…The abnormal folding and aggregation of functional proteins into amyloid is a typical feature of many age-related diseases, including Type II diabetes. Growing…”
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Causal relationship between gut microbiota and immune thrombocytopenia: a Mendelian randomization study of two samples by Guo, Dongmei, Chen, Qian, Wang, Guojun, Li, ChunPu

“…Some observational studies have shown that immune thrombocytopenia (ITP) is highly associated with the alteration-composition of gut microbiota. However, the…”
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Cobalt(iii)-catalyzed site-selective C-H amidation of pyridones and isoquinolones by Gao, Feng, Han, Xu, Li, Chunpu, Liu, Lingjun, Cong, Zhanqing, Liu, Hong

“…In this study, Cp*Co(iii)-catalyzed site-selective amidation of pyridones and isoquinolones using oxazolones as the amidation reagent is reported. This…”
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Cobalt-catalyzed C(sp 3 )-H/C(sp 2 )-H oxidative coupling between alkanes and benzamides by Li, Shuangjie, Wang, Bao, Dong, Guangyu, Li, Chunpu, Liu, Hong

“…A direct cobalt-catalyzed oxidative coupling between C(sp )-H in unactivated benzamides and C(sp )-H in simple alkanes, ethers and toluene derivatives was…”
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Ruthenium-Catalyzed C–H Activations for the Synthesis of Indole Derivatives by Haoran Zhu, Sen Zhao, Yu Zhou, Chunpu Li, Hong Liu

“…The synthesis of substituted indoles has received great attention in the field of organic synthesis methodology. C–H activation makes it possible to obtain a…”
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Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5 by Han, Haozhen, Li, Chunpu, Li, Man, Yang, Lisheng, Zhao, Sen, Wang, Zhifei, Liu, Hong, Liu, Dongxiang

“…Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases. They regulate many physiological processes and play important roles in inflammation, diabetes,…”
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Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer by Zhu, Wei, Chen, Hui, Wang, Yulan, Wang, Jiang, Peng, Xia, Chen, Xianjie, Gao, Yinglei, Li, Chunpu, He, Yulong, Ai, Jing, Geng, Meiyu, Zheng, Mingyue, Liu, Hong

“…A novel series of pyridin-3-amine derivatives were designed, synthesized, and evaluated as multitargeted protein kinase inhibitors for the treatment of…”
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Weighted gene co-expression network analysis revealed key biomarkers associated with the diagnosis of hypertrophic cardiomyopathy by Li, Xin, Wang, Chenxin, Zhang, Xiaoqing, Liu, Jiali, Wang, Yu, Li, Chunpu, Guo, Dongmei

“…Abstract Objective To reveal the molecular mechanism underlying the pathogenesis of HCM and find new effective therapeutic strategies using a systematic…”
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Effect of hyperlipidaemia to accelerate intervertebral disc degeneration in the injured rat caudal disc model by Zhang, Yuedong, Si, Meng, Li, Chunpu, Liu, Yi, Han, Yingguang, Nie, Lin, Wang, Mei

“…Dyslipidaemia is a well-known risk factor for the development of atherosclerosis, however, little is known about the effect of dyslipidaemia on intervertebral…”
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A two-step method for paroxysmal atrial fibrillation event detection based on machine learning by Wang, Ya'nan, Liu, Sen, Jia, Haijun, Deng, Xintao, Li, Chunpu, Wang, Aiguo, Yang, Cuiwei

“…Detection of atrial fibrillation (AF) events is significant for early clinical diagnosis and appropriate intervention. However, in existing detection…”
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Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL‑1 with Antitumor Activity by Gong, Qineng, Li, Chunpu, Wang, Haojie, Cao, Jinrui, Li, Zuo, Zhou, Mi, Li, Yan, Chu, Yong, Liu, Hong, Wang, Renxiao

“…MCL-1, an antiapoptotic member of the BCL-2 family, is dysregulated and overexpressed in various tumors. In tumors with MCL-1 overexpression, selective…”
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Surveillance of Borrelia miyamotoi-carrying ticks and genomic analysis of isolates in Inner Mongolia, China by Sato, Kozue, Liu, Dan, Cui, Yunhong, Yin, Xuhong, Zhang, Lihua, Li, Hong, Wang, Tingfu, Liu, Rongxin, Wu, Lijing, Lu, Saixia, Gao, Ting, Zhang, Zitong, Cao, Minzhi, Wang, Guodong, Li, Chunpu, Yan, Dacheng, Ohashi, Norio, Ando, Shuji, Kawabata, Hiroki

“…Abstract Background Borrelia miyamotoi is a newly described relapsing fever spirochete transmitted by ixodid tick species. Little is known about the prevalence…”
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A Case of Rice Body Synovitis of the Knee Joint by Haibo, Zhao, Tianrui, Wang, Wenlian, Song, Shenjie, Sun, Chunpu, Li, Xia, Zhao, Tengbo, Yu, Yingze, Zhang

“…Background Rice body synovitis (RBS) is a rare disease. It is prone to be developed due to rheumatoid disorder or tuberculosis infection. Additional infectious…”
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