Search Results - "Li, Cheuk wun"

Molecular Amino Acid Signatures in the MHC Class II Peptide-Binding Pocket Predispose to Autoimmune Thyroiditis in Humans and in Mice by Menconi, Francesca, Monti, Maria C., Greenberg, David A., Oashi, Taiji, Osman, Roman, Davies, Terry F., Ban, Yoshiyuki, Jacobson, Eric M., Concepcion, Erlinda S., Li, Cheuk Wun, Tomer, Yaron

“…Hashimoto's thyroiditis (HT) is associated with HLA, but the associated allele is still controversial. We hypothesized that specific HLA-DR pocket-sequence…”
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Genetic–epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity by Stefan, Mihaela, Wei, Chengguo, Lombardi, Angela, Li, Cheuk Wun, Concepcion, Erlinda S., Inabnet, William B., Owen, Randall, Zhang, Weijia, Tomer, Yaron

“…Graves disease (GD) is an autoimmune condition caused by interacting genetic and environmental factors. Genetic studies have mapped several single-nucleotide…”
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Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model by Li, Cheuk Wun, Osman, Roman, Menconi, Francesca, Faustino, Larissa C, Kim, Kookjoo, Clarke, Oliver B, Hou, Hanxi, Tomer, Yaron

“…Autoimmune polyglandular syndrome type 3 variant (APS3v) refers to an autoimmune condition in which both type 1 diabetes (T1D) and autoimmune thyroiditis…”
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Regulation of the Activin-Inhibin-Follistatin System by Bone Morphogenetic Proteins in the Zebrafish Ovary by Li, Cheuk Wun, Ge, Wei

“…In the zebrafish, the dynamic expression of the activin-inhibin-follistatin system during folliculogenesis and its exclusive localization (except follistatin)…”
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Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease by Huber, Amanda K, Finkelman, Fred D, Li, Cheuk Wun, Concepcion, Erlinda, Smith, Eric, Jacobson, Eric, Latif, Rauf, Keddache, Mehdi, Zhang, Weijia, Tomer, Yaron

“…The CD40 gene, an important immune regulatory gene, is also expressed and functional on nonmyeloid-derived cells, many of which are targets for tissue-specific…”
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Spatiotemporal Expression of Bone Morphogenetic Protein Family Ligands and Receptors in the Zebrafish Ovary: A Potential Paracrine-Signaling Mechanism for Oocyte-Follicle Cell Communication by WUN LI, Cheuk, WEI GE

“…The bone morphogenetic proteins (BMPs), originally identified by their abilities to induce bone and/or cartilage formation, have been reported to be involved…”
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Immunogenetics of autoimmune thyroid diseases: A comprehensive review by Lee, Hanna J, Li, Cheuk Wun, Hammerstad, Sara Salehi, Stefan, Mihaela, Tomer, Yaron

“…Abstract Both environmental and genetic triggers factor into the etiology of autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's…”
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Employing a Recombinant HLA-DR3 Expression System to Dissect Major Histocompatibility Complex II-Thyroglobulin Peptide Dynamism by Jacobson, Eric M., Yang, Heyi, Menconi, Francesca, Wang, Rong, Osman, Roman, Skrabanek, Luce, Li, Cheuk Wun, Fadlalla, Mohammed, Gandhi, Alisha, Chaturvedi, Vijaya, Smith, Eric P., Schwemberger, Sandy, Osterburg, Andrew, Babcock, George F., Tomer, Yaron

“…Previously, we have shown that statistical synergism between amino acid variants in thyroglobulin (Tg) and specific HLA-DR3 pocket sequence signatures…”
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Genetics and epigenetics of autoimmune thyroid diseases: Translational implications by Lee, Hanna J., Stefan–Lifshitz, Mihaela, Li, Cheuk Wun, Tomer, Yaron

“…Hashimoto's thyroiditis (HT) and Graves' disease (GD) are prevalent autoimmune disorders, representing opposite ends of the clinical spectrum of autoimmune…”
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Effective Inhibition of Thyroid Antigen Presentation Using Retro-Inverso Peptides in Experimental Autoimmune Thyroiditis: A Pathway Toward Immune Therapies of Thyroid Autoimmunity by Li, Cheuk Wun, Osman, Roman, Menconi, Francesca, Hou, Hanxi, Schechter, Clyde, Kozhakhmetova, Aizhan, Tomer, Yaron

“…Autoimmune thyroid diseases (AITD) represent the most common autoimmune diseases. However, current therapies focus on relieving the symptoms instead of curing…”
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Dissecting the role of the foxp3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: A genetic and functional analysis by Li, Cheuk Wun, Concepcion, Erlinda, Tomer, Yaron

“…We have previously shown that a (TC)n microsatellite in intron 5 of the Forkhead Box Protein 3 (FOXP3) gene was associated with a variant of the autoimmune…”
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Cepharanthine blocks TSH receptor peptide presentation by HLA-DR3: Therapeutic implications to Graves’ disease by Li, Cheuk Wun, Osman, Roman, Menconi, Francesca, Concepcion, Erlinda, Tomer, Yaron

“…We have previously identified a signature HLA-DR3 pocket variant, designated HLA-DRβ1-Arg74 that confers a high risk for Graves' Disease (GD). In view of the…”
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Identification of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases by Deep Sequencing of Linked Loci by Li, Cheuk Wun, Sachidanandam, Ravi, Jayaprakash, Anitha, Yi, Zhengzi, Zhang, Weijia, Stefan-Lifshitz, Mihaela, Conception, Erlinda, Tomer, Yaron

“…Context: Genetic risk factors play a major role in the pathoetiology of autoimmune thyroid diseases (AITD). So far, only common risk variants have been…”
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Flexible peptide recognition by HLA-DR triggers specific autoimmune T-cell responses in autoimmune thyroiditis and diabetes by Li, Cheuk Wun, Osman, Roman, Menconi, Francesca, Concepcion, Erlinda S, Tomer, Yaron

“…Abstract Autoimmune polyglandular syndrome 3 variant (APS3v) refers to the co-occurrence of autoimmune thyroiditis (AITD) and type 1 diabetes (T1D) within the…”
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Regulation of the Activin-Inhibin-Follistatin System by Bone Morphogenetic Proteins in the Zebrafish Ovary1 by Li, Cheuk Wun, Ge, Wei

“…In the zebrafish, the dynamic expression of the activin-inhibin-follistatin system during folliculogenesis and its exclusive localization (except follistatin)…”
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Differential regulation of gonadotropin receptors by bone morphogenetic proteins in the zebrafish ovary by Li, Cheuk Wun, Zhou, Rui, Ge, Wei

“…Graphical abstract Highlights ► Recombinant CHO cells expressing Bmp were co-cultured with zebrafish follicle cells. ► zfBmp2b and zfBmp4 increased lhcgr while…”
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CD40 Signaling in Graves Disease Is Mediated Through Canonical and Noncanonical Thyroidal Nuclear Factor κB Activation by Lee, Hanna J., Lombardi, Angela, Stefan, Mihaela, Li, Cheuk wun, Inabnet, William B., Owen, Randall P., Concepcion, Erlinda, Tomer, Yaron

“…Abstract CD40, a tumor necrosis factor receptor, is a major immune-modulating susceptibility gene for Graves disease (GD) as well as for a variety of other…”
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Spatiotemporal Expression of Bone Morphogenetic Protein Family Ligands and Receptors in the Zebrafish Ovary: A Potential Paracrine-Signaling Mechanism for Oocyte-Follicle Cell Communication1 by Li, Cheuk Wun, Ge, Wei

“…The bone morphogenetic proteins (BMPs), originally identified by their abilities to induce bone and/or cartilage formation, have been reported to be involved…”
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OR19-5 Dissecting Thyroidal Pathways Activated by PD-L1 Blockade Identifies New Mechanisms for Thyroiditis Triggered by Immune Checkpoint Inhibitors by Hou, Hanxi, Li, Cheuk Wun, Tomer, Yaron, Yi, Zhengzi, Zhang, Weijia, Stefan Lifshitz, Mihaela

“…Programmed death-ligand 1 (PD-L1) is a strong immunosuppressor that inhibits T-cell activation by binding to its receptor (PD-1) on T-cells. Blocking the…”
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Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis by Li, Cheuk Wun, Menconi, Francesca, Osman, Roman, Mezei, Mihaly, Jacobson, Eric M., Concepcion, Erlinda, David, Chella S., Kastrinsky, David B., Ohlmeyer, Michael, Tomer, Yaron

“…We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring…”
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