Search Results - "Li, Austin"

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer by Wen, Yang-An, Xiong, Xiaopeng, Zaytseva, Yekaterina Y., Napier, Dana L., Vallee, Emma, Li, Austin T., Wang, Chi, Weiss, Heidi L., Evers, B. Mark, Gao, Tianyan

“…Sterol regulatory element-binding proteins (SREBPs) belong to a family of transcription factors that regulate the expression of genes required for the…”
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SoxB1 transcription factors are essential for initiating and maintaining neural plate border gene expression by Schock, Elizabeth N, York, Joshua R, Li, Austin P, Tu, Ashlyn Y, LaBonne, Carole

“…SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles…”
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The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer by Wen, Yang-An, Xiong, Xiaopeng, Scott, Timothy, Li, Austin T., Wang, Chi, Weiss, Heidi L., Tan, Li, Bradford, Emily, Fan, Teresa W. M., Chandel, Navdeep S., Barrett, Terrence A., Gao, Tianyan

“…Cancer cells are known to upregulate aerobic glycolysis to promote growth, proliferation, and survival. However, the role of mitochondrial respiration in…”
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Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer by Guo, Bianqin, Xiong, Xiaopeng, Hasani, Sumati, Wen, Yang-An, Li, Austin T., Martinez, Rebecca, Skaggs, Ashley T., Gao, Tianyan

“…Aberrant activation of endoplasmic reticulum (ER) stress by extrinsic and intrinsic factors contributes to tumorigenesis and resistance to chemotherapies in…”
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An open-source transparent microelectrode array by Weaver, Isaac A, Li, Austin W, Shields, Brenda C, Tadross, Michael R

“…The micro-electrode array (MEA) is a cell-culture surface with integrated electrodes used for assays of electrically excitable cells and tissues. MEAs have…”
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Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer by Gan, Tong, Stevens, Ashley T., Xiong, Xiaopeng, Wen, Yang-An, Farmer, Trevor N., Li, Austin T., Stevens, Payton D., Golshani, Sanam, Weiss, Heidi L., Evers, B. Mark, Gao, Tianyan

“…Wnt signaling dysregulation promotes tumorigenesis in colorectal cancer (CRC). We investigated the role of PTPRF, a receptor-type tyrosine phosphatase, in…”
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Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer by Stevens, Payton D, Wen, Yang-An, Xiong, Xiaopeng, Zaytseva, Yekaterina Y, Li, Austin T, Wang, Chi, Stevens, Ashley T, Farmer, Trevor N, Gan, Tong, Weiss, Heidi L, Inagaki, Masaki, Marchetto, Sylvie, Borg, Jean-Paul, Gao, Tianyan

“…Erbin belongs to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that plays important roles in orchestrating cell signaling. Here,…”
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Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate by Li, Austin C., Cui, Donghui, Yu, Erya, Dobson, Kyle, Hellriegel, Edward T., Robertson Jr, Philmore

“…1. Aldehyde oxidase (AO enzymes)-mediated oxidation predominantly occurs at a carbon atom adjacent to the nitrogen on aromatic azaheterocycles. In the current…”
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Bone marrow aspirate and bone marrow aspirate concentrate: Does the literature support use in long-bone nonunion and provide new insights into mechanism of action? by Moyal, Andrew J., Li, Austin W., Adelstein, Jeremy M., Moon, Tyler J., Napora, Joshua K.

“…Purpose To assess the use of bone marrow aspirate (BM) and bone marrow aspirate concentrate (BMAC) in the treatment of long-bone nonunion and to understand…”
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Structural identification of imatinib cyanide adducts by mass spectrometry and elucidation of bioactivation pathway by Li, Austin C., Yu, Erya, Ring, Steven C., Chovan, James P.

“…RATIONALE Recent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The…”
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Boronic Acid-Containing Proteasome Inhibitors: Alert to Potential Pharmaceutical Bioactivation by Li, Austin C, Yu, Erya, Ring, Steven C, Chovan, James P

“…Medicinal chemists try to avoid certain organic functional groups, summarized in an ever-growing list, in order to avoid the potential bioactivation to…”
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Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite by Li, Austin C., Chovan, James P., Yu, Erya, Zamora, Ismael

“…1. There has been a lack of in vivo metabolite profiling update of hydrocodone since the original report on species differences was published in 1978. As such,…”
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Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification by Li, Austin C., Ding, Jie, Jiang, Xiangyu, Denissen, Jon

“…The relatively high background matrix in in vivo samples typically poses difficulties in drug metabolite identification, and causes repeated analytical runs on…”
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'N-in-one' strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan by Li, Austin C., Gohdes, Mark A., Shou, Wilson Z.

“…This paper describes a new strategy that utilizes the fast trap mode scan of the hybrid triple quadrupole linear ion trap (QqQLIT) for the identification of…”
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Identification of imine or enamine drug metabolites using online hydrogen/deuterium exchange and exact mass measurements by Li, Austin C., Yu, Erya, Ring, Steven C., Chovan, James P.

“…RATIONALE Drug metabolites that have imine or enamine partial structures cause extra mass‐to‐charge (m/z) increases in online hydrogen/deuterium exchange (HDX)…”
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Simultaneous determination of norethindrone and ethinyl estradiol in human plasma by high performance liquid chromatography with tandem mass spectrometry—experiences on developing a highly selective method using derivatization reagent for enhancing sensitivity by Li, Wenkui, Li, Ying-He, Li, Austin C., Zhou, Shaolian, Naidong, Weng

“…In the present work, for the first time, a liquid chromatographic method with tandem mass spectrometric detection (LC–MS/MS) for the simultaneous analysis of…”
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Information-Seeking Behavior for COVID-19 Boosters in China: A Cross-Sectional Survey by Li, Xiaoshan Austin, Wu, Qiwei Luna, Hubbard, Katharine, Hwang, Jooyun, Zhong, Lingzi

“…As China launches its second COVID-19 booster campaign and races to bring new vaccine technologies to protect against severe COVID-19 infections, there is…”
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Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms by Li, Austin C., Shou, Wilson Z., Mai, Ting T., Jiang, Xiang-yu

“…This paper describes the complete profiling and characterization of in vitro metabolites of the antidepressant agent nefazodone (NEF) generated by human liver…”
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Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument by Li, Austin C., Alton, Dennis, Bryant, Matthew S., Shou, Wilson Z.

“…Bioanalytical support of plasma pharmacokinetic (PK) studies for drug discovery programs primarily involves the quantitative analysis of dosed compounds using…”
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Proposal of buspirone collision-induced dissociation rearrangement by exact mass measurements by Li, Austin C., Shou, Wilson Z., Jiang, Xiangyu

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