Search Results - "Li, Alex X."

Reproducibility of Neurite Orientation Dispersion and Density Imaging (NODDI) in rats at 9.4 Tesla by McCunn, Patrick, Gilbert, Kyle M, Zeman, Peter, Li, Alex X, Strong, Michael J, Khan, Ali R, Bartha, Robert

“…Neurite Orientation Dispersion and Density Imaging (NODDI) is a diffusion MRI (dMRI) technique used to characterize tissue microstructure by compartmental…”
Get full text

Diffusion-weighted tractography in the common marmoset monkey at 9.4T by Schaeffer, David J, Adam, Ramina, Gilbert, Kyle M, Gati, Joseph S, Li, Alex X, Menon, Ravi S, Everling, Stefan

“…The common marmoset ( ) is a small New World primate that is becoming increasingly popular in the neurosciences as an animal model of preclinical human…”
Get full text

Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent by McVicar, Nevin, Li, Alex X., Suchý, Mojmír, Hudson, Robert H. E., Menon, Ravi S., Bartha, Robert

“…Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and…”
Get full text

Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission by Guzman, Monica S, De Jaeger, Xavier, Raulic, Sanda, Souza, Ivana A, Li, Alex X, Schmid, Susanne, Menon, Ravi S, Gainetdinov, Raul R, Caron, Marc G, Bartha, Robert, Prado, Vania F, Prado, Marco A M

“…Cholinergic neurons in the striatum are thought to play major regulatory functions in motor behaviour and reward. These neurons express two vesicular…”
Get full text

A sensitive PARACEST contrast agent for temperature MRI: Eu3+-DOTAM-glycine (Gly)-phenylalanine (Phe) by Li, Alex X., Wojciechowski, Filip, Suchy, Mojmir, Jones, Craig K., Hudson, Robert H.E., Menon, Ravi S., Bartha, Robert

“…Tissue temperature is a fundamental physiological parameter that can provide insight into pathological processes. The purpose of this study was to develop and…”
Get full text

Quantitative Tissue Ph Measurement during Cerebral Ischemia Using Amine and Amide Concentration-Independent Detection (AACID) with MRI by McVicar, Nevin, Li, Alex X, Gonçalves, Daniela F, Bellyou, Miranda, Meakin, Susan O, Prado, Marco AM, Bartha, Robert

“…Tissue pH is an indicator of altered cellular metabolism in diseases including stroke and cancer. Ischemic tissue often becomes acidic due to increased…”
Get full text

Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine by McVicar, Nevin, Li, Alex X., Meakin, Susan O., Bartha, Robert

“…Increased lactate production through glycolysis in aerobic conditions is a hallmark of cancer. Some anticancer drugs have been designed to exploit elevated…”
Get full text

Imaging of Glycosaminoglycans in Ascending Aortic Aneurysms With Chemical Exchange Saturation Transfer MRI by Mortuza, Rokhsana, Ching-Johnson, Justin A., Yin, Hao, O’Neil, Caroline, Cronin, Alicia E., Randhawa, Varinder K., Nong, Zengxuan, Hashi, Abdulaziz Ahmed, Li, Alex X., Bartha, Robert, Chu, Michael W.A., Pickering, J. Geoffrey

Get full text

Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents by Li, Alex X., Hudson, Robert H.E., Barrett, John W., Jones, Craig K., Pasternak, Stephen H., Bartha, Robert

“…Signal loss due to magnetization transfer (MT) from the macromolecular protons of biological tissues is an important consideration for the in vivo detection of…”
Get full text

Mapping microarchitectural degeneration in the dilated ascending aorta with ex vivo diffusion tensor imaging by Wang, Mofei, Ching-Johnson, Justin A, Yin, Hao, O'Neil, Caroline, Li, Alex X, Chu, Michael W A, Bartha, Robert, Pickering, J Geoffrey

“…Thoracic aortic aneurysms (TAAs) carry a risk of catastrophic dissection. Current strategies to evaluate this risk entail measuring aortic diameter but do not…”
Get full text

Introduction of Peripheral Carboxylates to Decrease the Charge on Tm(3+) DOTAM-Alkyl Complexes: Implications for Detection Sensitivity and in Vivo Toxicity of PARACEST MRI Contrast Agents by Suchý, Mojmír, Milne, Mark, Elmehriki, Adam A H, McVicar, Nevin, Li, Alex X, Bartha, Robert, Hudson, Robert H E

“…A series of structurally modified Tm(3+) DOTAM-alkyl complexes as potential PARACEST MRI contrast agents has been synthesized with the aim to decrease the…”
Get full text

Introduction of Peripheral Carboxylates to Decrease the Charge on Tm3+ DOTAM-Alkyl Complexes: Implications for Detection Sensitivity and in Vivo Toxicity of PARACEST MRI Contrast Agents by Suchý, Mojmír, Milne, Mark, Elmehriki, Adam A. H, McVicar, Nevin, Li, Alex X, Bartha, Robert, Hudson, Robert H. E

“…A series of structurally modified Tm3+ DOTAM-alkyl complexes as potential PARACEST MRI contrast agents has been synthesized with the aim to decrease the…”
Get full text

In vivo detection of MRI-PARACEST agents in mouse brain tumors at 9.4 T by Li, Alex X., Suchy, Mojmir, Li, Chunhui, Gati, Joseph S., Meakin, Susan, Hudson, Robert H. E., Menon, Ravi S., Bartha, Robert

“…Paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents are under development for biological target identification by magnetic resonance…”
Get full text

Preliminary evaluation of PARACEST MRI agents for the detection of nitric oxide synthase by Suchý, Mojmír, Li, Alex X, Liu, Yin, Feng, Qingping, Bartha, Robert, Hudson, Robert H.E

“…Several paramagnetic chemical exchange saturation transfer magnetic resonance imaging (PARACEST MRI) agents for the potential detection of nitric oxide…”
Get full text

A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies by Suchý, Mojmír, Ta, Robert, Li, Alex X, Wojciechowski, Filip, Pasternak, Stephen H, Bartha, Robert, Hudson, Robert H E

“…Overexpression of the aspartyl protease cathepsin D is associated with certain cancers and Alzheimer's disease; thus, it is a potentially useful imaging…”
Get more information

In vivo detection of PARACEST agents with relaxation correction by Jones, Craig K., Li, Alex X., Suchý, Mojmír, Hudson, Robert H. E., Menon, Ravi S., Bartha, Robert

“…Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the…”
Get full text

Dynamic optical imaging of a cleavable CPP-bound, dual-NIR fluorescent/MRI probe targeting cathepsin D by Snir, Jonatan, Suchy, Mojmir, Li, Alex X, St. Lawrence, Keith, Hudson, Robert, Pasternak, Stephen, Bartha, Robert

Get full text

Dynamic optical imaging of a cleavable CPP-bound dual NIR fluorescent/MRI probe targeting cathepsin D by Snir, Jonatan, Suchy, Mojmir, Li, Alex X, Lawrence, Keith St, Hudson, Robert H.E, Pasternak, Stephen, Bartha, Robert

Get full text

A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent by Suchý, Mojmír, Li, Alex X, Bartha, Robert, Hudson, Robert H E

“…Several approaches towards asymmetrically derivatized peptide-decorated cyclens that yield lanthanide metal chelators, in which three of the nitrogen atoms of…”
Get more information

DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI by Suchý, Mojmír, Li, Alex X, Milne, Mark, Bartha, Robert, Hudson, Robert H E

“…A synthetic methodology was developed for the preparation of metal-chelating ligands that possess arginine pendant groups relying on the alkylation of…”
Get more information