Search Results - "Lhoumeau, Anne Catherine"
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The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway
Published in The Journal of biological chemistry (18-12-2015)“…The non-canonical WNT/planar cell polarity (WNT/PCP) pathway plays important roles in morphogenetic processes in vertebrates. Among WNT/PCP components, protein…”
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Outcomes of acute myeloid leukemia patients who responded to venetoclax and azacitidine and stopped treatment
Published in American journal of hematology (01-10-2024)“…Venetoclax‐azacitidine is the standard of treatment for unfit acute myeloid leukemia patients. In the VIALE‐A study, treatment was given until progression but…”
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Venetoclax‐based non‐intensive induction followed by allogenic stem‐cell transplantation in elderly acute myeloid leukemia patients with adverse cytogenetics
Published in European journal of haematology (01-12-2024)“…Introduction Elderly acute myeloid leukemia (AML) patients with poor‐risk cytogenetics have a poor outcome with intensive chemotherapy (IC). While Venetoclax…”
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Acute erythroid leukemias have a distinct molecular hierarchy from non-erythroid acute myeloid leukemias
Published in Haematologica (Roma) (01-07-2020)Get full text
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Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer
Published in PloS one (11-05-2015)“…Biomarkers and novel therapeutic targets are urgently needed in colorectal cancer (CRC). The pseudo tyrosine kinase receptor 7 (PTK7) is involved in planar…”
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Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling
Published in EMBO reports (01-01-2011)“…The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog…”
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PTK7: A cell polarity receptor with multiple facets
Published in Cell cycle (Georgetown, Tex.) (15-04-2011)“…PTK7 is a tyrosine kinase receptor implicated in planar cell polarity, a process with multiple implications at the cellular and organism levels. Loss of…”
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Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton
Published in Nature cell biology (01-09-2013)“…It has been shown that planar cell polarity (PCP) signalling and cilium positioning are linked. Montcouquiol and colleagues now show that G-protein signalling,…”
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Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration
Published in The Journal of immunology (1950) (15-05-2016)“…Hematopoietic stem cells (HSCs) located in adult bone marrow or fetal liver in mammals produce all cells from the blood system. At the top of the hierarchy are…”
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Adhesion receptors involved in HSC and early-B cell interactions with bone marrow microenvironment
Published in Cellular and molecular life sciences : CMLS (01-02-2016)“…Hematopoiesis takes place in the bone marrow of adult mammals and is the process by which blood cells are replenished every day throughout life…”
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Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms (MPO-MDS-Valid): protocol for a multicentre diagnostic accuracy study
Published in BMJ open (17-06-2024)“…IntroductionMany patients referred for suspicion of myelodysplastic neoplasm (MDS) are subjected to unnecessary discomfort from bone marrow aspiration, due to…”
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The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome
Published in Blood (30-09-2010)“…The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway. It plays a major role during…”
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Persistence of PNH Clones over Time: Insights from the Mid-Term Analysis of the French Nation-Wide Multicenter Prospective Observational Study
Published in Blood (13-11-2019)“…Introduction: Since the publication of the International Guidelines (Borowitz, 2010; Illingworth, 2018), no study has assessed the long-term evolution of…”
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Standardization of Flow Cytometric Immunophenotyping for Hematological Malignancies: The FranceFlow Group Experience
Published in Cytometry. Part A (01-09-2019)“…Flow cytometry is broadly used for the identification, characterization, and monitoring of hematological malignancies. However, the use of clinical flow…”
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Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published in Journal of visualized experiments (03-11-2018)“…A working group initiated within the French Cytometry Association (AFC) was developed in order to harmonize the application of multiparameter flow cytometry…”
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Neutrophil PNH Type II Cells Are Associated with Thrombosis and Bone Marrow Failure without Hemolysis: Evidence from Analysis of the 5-Year French Nation-Wide Multicenter Observational Study
Published in Blood (02-11-2023)“…Introduction Flow cytometry (FCM) is the gold standard test to diagnose a PNH clone, type II and III cells being defined by a partial or a complete deficiency,…”
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Rare PNH Cells May be Considered As Genuine PNH Clone: Insights from Analysis of the 5-Year French Nation-Wide Multicenter Observational Study
Published in Blood (15-11-2022)Get full text
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Clinical, Cytogenetic and Molecular Characterization of a 96 MDS and AML Cohort with TP53 Mutation
Published in Blood (02-11-2023)“…Introduction The last European LeukamiaNet (ELN) recommendations (Döhner H. et al. Blood. 2022) and the International Consensus Classification (ICC, Hasserjian…”
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AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network
Published in Blood (15-11-2022)Get full text
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Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia
Published in Leukemia (01-06-2021)Get full text
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