Search Results - "Leyen, Klaus"

Lipoxygenase: an emerging target for stroke therapy by van Leyen, Klaus

“…Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care,…”
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Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke by Cheng, Guangsen, Zhao, Wei, Xin, Yongjie, Huang, Guomin, Liu, Yongkang, Li, Zhongliang, Zhan, Meixiao, Li, Yong, Lu, Ligong, Leyen, Klaus, Liu, Yu

“…Thrombolytic stroke therapy with tissue plasminogen activator (tPA) is limited by risks of hemorrhagic transformation (HT). We have reported that a new…”
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Cell-cell signaling in the neurovascular unit by Lok, Josephine, Gupta, Punkaj, Guo, Shuzhen, Kim, Woo Jean, Whalen, Michael J, van Leyen, Klaus, Lo, Eng H

“…Historically, the neuron has been the conceptual focus for almost all of neuroscience research. In recent years, however, the concept of the neurovascular unit…”
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The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis by Maher, Pamela, van Leyen, Klaus, Dey, Partha Narayan, Honrath, Birgit, Dolga, Amalia, Methner, Axel

“…[Display omitted] •Oxytosis/ferroptosis causes cell death by glutathione depletion and Ca2+ influx.•Ca2+ influx occurs through channels involved in…”
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The future of neuroprotection in stroke by Chamorro, Ángel, Lo, Eng H, Renú, Arturo, van Leyen, Klaus, Lyden, Patrick D

“…Investigators acknowledge the limitations of rodent or non-human primate stroke models, hundreds of putative neuroprotectants have been evaluated in…”
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Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy by Jang, Insook, Park, Sujin, Cho, Jin Won, Yigitkanli, Kazim, van Leyen, Klaus, Roth, Jürgen

“…12/15-lipoxygenase (12/15-LOX) is involved in organelle homeostasis by degrading mitochondria in maturing red blood cells and by eliminating excess peroxisomes…”
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Following experimental stroke, the recovering brain is vulnerable to lipoxygenase‐dependent semaphorin signaling by Pekcec, Anton, Yigitkanli, Kazim, Jung, Joo Eun, Pallast, Stefanie, Xing, Changhong, Antipenko, Alexander, Minchenko, Maria, Nikolov, Dimitar B., Holman, Theodore R., Lo, Eng H., Leyen, Klaus

“…Recovery from stroke is limited, in part, by an inhibitory environment in the postischemic brain, but factors preventing successful remodeling are not well…”
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12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat by Leiria, Luiz Osório, Wang, Chih-Hao, Lynes, Matthew D., Yang, Kunyan, Shamsi, Farnaz, Sato, Mari, Sugimoto, Satoru, Chen, Emily Y., Bussberg, Valerie, Narain, Niven R., Sansbury, Brian E., Darcy, Justin, Huang, Tian Lian, Kodani, Sean D., Sakaguchi, Masaji, Rocha, Andréa L., Schulz, Tim J., Bartelt, Alexander, Hotamisligil, Gökhan S., Hirshman, Michael F., van Leyen, Klaus, Goodyear, Laurie J., Blüher, Matthias, Cypess, Aaron M., Kiebish, Michael A., Spite, Matthew, Tseng, Yu-Hua

“…Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain body…”
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CPEB4 Is a Cell Survival Protein Retained in the Nucleus upon Ischemia or Endoplasmic Reticulum Calcium Depletion by Kan, Ming-Chung, Oruganty-Das, Aparna, Cooper-Morgan, Amalene, Jin, Guang, Swanger, Sharon A., Bassell, Gary J., Florman, Harvey, van Leyen, Klaus, Richter, Joel D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation by Xing, Changhong, Wang, Xiaoshu, Cheng, Chongjie, Montaner, Joan, Mandeville, Emiri, Leung, Wendy, van Leyen, Klaus, Lok, Josephine, Wang, Xiaoying, Lo, Eng H

“…BACKGROUND AND PURPOSE—We explored the hypothesis that injured neurons release lipocalin-2 as a help me signal. METHODS—In vivo lipocalin-2 responses were…”
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Opening the time window by van Leyen, Klaus, Wang, Xiaoying, Selim, Magdy, Lo, Eng H

“…Abstract The recently completed EXTEND trial tested the idea that tissue plasminogen activator thrombolysis can be safely extended up to 9 h after stroke onset…”
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12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes by Cakir-Aktas, Canan, Bodur, Ebru, Yemisci, Muge, van Leyen, Klaus, Karatas, Hulya

“…Introduction: Lipoxygenases (LOXs) have essential roles in stroke, atherosclerosis, diabetes, and hypertension. 12/15-LOX inhibition was shown to reduce…”
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Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke by Li, Wenlu, Mandeville, Emiri T., Durán-Laforet, Violeta, Fukuda, Norito, Yu, Zhanyang, Zheng, Yi, Held, Aaron, Park, Ji-Hyun, Nakano, Takafumi, Tanaka, Masayoshi, Shi, Jingfei, Esposito, Elga, Niu, Wanting, Xing, Changhong, Hayakawa, Kazuhide, Lizasoain, Ignacio, van Leyen, Klaus, Ji, Xunming, Wainger, Brian J., Moro, Maria A., Lo, Eng H.

“…The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for…”
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STAT-Dependent Upregulation of 12/15-Lipoxygenase Contributes to Neuronal Injury after Stroke by Jung, Joo Eun, Karatas, Hulya, Liu, Yu, Yalcin, Ayfer, Montaner, Joan, Lo, Eng H, van Leyen, Klaus

“…Oxidative stress is a major brain injury mechanism after ischemic stroke. 12/15-lipoxygenase (12/15-LOX) is a key mediator of oxidative stress, contributing to…”
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Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease by Smirnova, Natalya A, Kaidery, Navneet Ammal, Hushpulian, Dmitry M, Rakhman, Ilay I, Poloznikov, Andrey A, Tishkov, Vladimir I, Karuppagounder, Saravanan S, Gaisina, Irina N, Pekcec, Anton, Leyen, Klaus Van, Kazakov, Sergey V, Yang, Lichuan, Thomas, Bobby, Ratan, Rajiv R, Gazaryan, Irina G

“…Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase…”
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Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies by Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H, van Leyen, Klaus, Maloney, David J, Holman, Theodore R

“…A key challenge facing drug discovery today is variability of the drug target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes…”
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Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke by Yigitkanli, Kazim, Pekcec, Anton, Karatas, Hulya, Pallast, Stefanie, Mandeville, Emiri, Joshi, Netra, Smirnova, Natalya, Gazaryan, Irina, Ratan, Rajiv R., Witztum, Joseph L., Montaner, Joan, Holman, Theodore R., Lo, Eng H., van Leyen, Klaus

“…Targeting newly identified damage pathways in the ischemic brain can help to circumvent the currently severe limitations of acute stroke therapy. Here we show…”
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12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress by Pallast, Stefanie, Arai, Ken, Wang, Xiaoying, Lo, Eng H, van Leyen, Klaus

“…12/15-Lipoxygenase (12/15-LOX) is an important mediator of brain injury following experimental stroke in rodents. It contributes to neuronal death, but the…”
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Baicalein and 12/15-lipoxygenase in the ischemic brain by VAN LEYEN, Klaus, HAHN YOUNG KIM, LEE, Seong-Ryong, GUANG JIN, ARAI, Ken, LO, Eng H

“…The natural product baicalein is a specific inhibitor of 12/15-lipoxygenase, but it also has antioxidant properties. The current study was designed to test if…”
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CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation by Hayakawa, Kazuhide, Pham, Loc-Duyen D, Seo, Ji Hae, Miyamoto, Nobukazu, Maki, Takakuni, Terasaki, Yasukazu, Sakadžić, Sava, Boas, David, van Leyen, Klaus, Waeber, Christian, Kim, Kyu-Won, Arai, Ken, Lo, Eng H

“…There are numerous barriers to white matter repair after central nervous system injury and the underlying mechanisms remain to be fully understood. In this…”
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