Search Results - "Ley, V"

On Being Green: Can Flow Chemistry Help? by Ley, Steven V.

“…The principles of Green Chemistry are important but challenging drivers for most modern synthesis programs. To meet these challenges new flow chemistry tools…”
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Flow Chemistry: Intelligent Processing of Gas–Liquid Transformations Using a Tube-in-Tube Reactor by Brzozowski, Martin, O’Brien, Matthew, Ley, Steven V., Polyzos, Anastasios

“…Conspectus The previous decade has witnessed the expeditious uptake of flow chemistry techniques in modern synthesis laboratories, and flow-based chemistry is…”
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Organic Synthesis: March of the Machines by Ley, Steven V., Fitzpatrick, Daniel E., Ingham, Richard. J., Myers, Rebecca M.

“…Organic synthesis is changing; in a world where budgets are constrained and the environmental impacts of practice are scrutinized, it is increasingly…”
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An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals by Baumann, Marcus, Baxendale, Ian R, Ley, Steven V, Nikbin, Nikzad

“…This review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent…”
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Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server by Fitzpatrick, Daniel E., Maujean, Timothé, Evans, Amanda C., Ley, Steven V.

“…The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find…”
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Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines by Grainger, Rachel, Heightman, Tom D, Ley, Steven V, Lima, Fabio, Johnson, Christopher N

“…In fragment-based drug discovery (FBDD), a weakly binding fragment hit is elaborated into a potent ligand by bespoke functionalization along specific…”
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A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters by Lima, Fabio, Sharma, Upendra K., Grunenberg, Lars, Saha, Debasmita, Johannsen, Sandra, Sedelmeier, Joerg, Van der Eycken, Erik V., Ley, Steven V.

“…We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin‐3‐ol or 4‐dimethylaminopyridine and a photoredox…”
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Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid Contact by O’Brien, Matthew, Baxendale, Ian R, Ley, Steven V

“…A flow-through chemistry apparatus has been developed which allows gases and liquids to contact via a semipermeable Teflon AF-2400 membrane. In this…”
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Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)-C(sp3) Cross-Couplings in Flow by Lima, Fabio, Kabeshov, Mikhail A., Tran, Duc N., Battilocchio, Claudio, Sedelmeier, Joerg, Sedelmeier, Gottfried, Schenkel, Berthold, Ley, Steven V.

“…We report herein a new method for the photoredox activation of boronic esters. Using these reagents, an efficient and high‐throughput continuous flow process…”
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Machine-Assisted Organic Synthesis by Ley, Steven V., Fitzpatrick, Daniel E., Myers, Rebecca M., Battilocchio, Claudio, Ingham, Richard. J.

“…In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated…”
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Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide by Battilocchio, Claudio, Hawkins, Joel M, Ley, Steven V

“…A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing…”
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Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry by Ritson, Dougal J., Battilocchio, Claudio, Ley, Steven V., Sutherland, John D.

“…When considering life’s aetiology, the first questions that must be addressed are “how?” and “where?” were ostensibly complex molecules, considered necessary…”
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A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters by Watanabe, Eiichi, Chen, Yiding, May, Oliver, Ley, Steven V.

“…A practically useful coupling reaction between aromatic halides and redox‐active esters was realized by nickel catalysis through the use of a packed zinc bed…”
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A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia by Battilocchio, Claudio, Hawkins, Joel M, Ley, Steven V

“…A flow chemistry Meerwein–Ponndorf–Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The…”
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Flow Chemistry Meets Advanced Functional Materials by Myers, Rebecca M., Fitzpatrick, Daniel E., Turner, Richard M., Ley, Steven V.

“…Flow chemistry and continuous processing techniques are beginning to have a profound impact on the production of functional materials ranging from quantum…”
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The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor by Polyzos, Anastasios, O'Brien, Matthew, Petersen, Trine P., Baxendale, Ian R., Ley, Steven V.

“…Keep it simple: A gas–liquid flow reactor has been developed based on a gas permeable tube‐in‐tube configuration which effectively delivers gas to a liquid…”
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Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow by Musio, Biagia, Gala, Elena, Ley, Steven V

“…The productive use of toxic waste materials derived from industrial processes is one of the main goals of modern chemical research to increase sustainability…”
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Iterative reactions of transient boronic acids enable sequential C–C bond formation by Battilocchio, Claudio, Feist, Florian, Hafner, Andreas, Simon, Meike, Tran, Duc N., Allwood, Daniel M., Blakemore, David C., Ley, Steven V.

“…The ability to form multiple carbon–carbon bonds in a controlled sequence and thus rapidly build molecular complexity in an iterative fashion is an important…”
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A flow-based synthesis of imatinib: the API of Gleevec by Hopkin, Mark D, Baxendale, Ian R, Ley, Steven V

“…A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in…”
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Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles by Baxendale, Ian R., Ley, Steven V., Mansfield, Andrew C., Smith, Christopher D.

“…Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied…”
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