Search Results - "Lewkowicz, Elizabeth S."

Synthesis of Chiral Acyclic Pyrimidine Nucleoside Analogues from DHAP-Dependent Aldolases by Nigro, Mariano, Sánchez-Moreno, Israél, Benito-Arenas, Raúl, Valino, Ana L, Iribarren, Adolfo M, Veiga, Nicolás, García-Junceda, Eduardo, Lewkowicz, Elizabeth S

“…Dihydroxyacetone phosphate (DHAP)-dependent aldolases catalyze the aldol addition of DHAP to a variety of aldehydes and generate compounds with two…”
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Biocatalytic approaches applied to the synthesis of nucleoside prodrugs by Iglesias, Luis E., Lewkowicz, Elizabeth S., Medici, Rosario, Bianchi, Paola, Iribarren, Adolfo M.

“…Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their…”
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Methyltransferases: Functions and Applications by Abdelraheem, Eman, Thair, Benjamin, Varela, Romina Fernández, Jockmann, Emely, Popadić, Désirée, Hailes, Helen C., Ward, John M., Iribarren, Adolfo M., Lewkowicz, Elizabeth S., Andexer, Jennifer N., Hagedoorn, Peter‐Leon, Hanefeld, Ulf

“…In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification…”
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Streptomyces griseus: A new biocatalyst with N-oxygenase activity by Nóbile, Matías L., Stricker, Abigail M., Iribarren, Adolfo M., Lewkowicz, Elizabeth S.

“…[Display omitted] •S. griseus was selected by screening as new AurF-like source.•pNBA was obtained by N-oxygenation of pABA using S. griseus whole cells.•A…”
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N-oxygenation of amino compounds: Early stages in its application to the biocatalyzed preparation of bioactive compounds by Nóbile, Matías L., Stricker, Abigail M., Marchesano, Lucas, Iribarren, Adolfo M., Lewkowicz, Elizabeth S.

“…Among the compounds that contain unusual functional groups, nitro is perhaps one of the most interesting due to the valuable properties it confers on…”
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New and highly active microbial phosphotriesterase sources by Santillan, Julia Y, Dettorre, Lucas A, Lewkowicz, Elizabeth S, Iribarren, Adolfo M

“…Many toxic insecticides used worldwide as well as some chemical warfare agents are phosphotriester derivatives. Therefore, detoxification of organophosphorus…”
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Citrobacter koseri immobilized on agarose beads for nucleoside synthesis: a potential biocatalyst for preparative applications by Nóbile, Matías L., Iribarren, Adolfo M., Lewkowicz, Elizabeth S.

“…The biocatalyzed synthesis of purine nucleosides and their analogs is a case widely studied due to the high pharmaceutical interest of these compounds,…”
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N-Acetylneuraminic acid aldolase-catalyzed synthesis of acyclic nucleoside analogues carrying a 4-hydroxy-2-oxoacid moiety by Nigro, Mariano J., Palazzolo, Martín A., Colasurdo, Diego, Iribarren, Adolfo M., Lewkowicz, Elizabeth S.

“…N-Acetylneuraminic acid aldolase (NeuAcA) (EC 4.1.3.3) is a pyruvate-dependent class I aldolase that catalyzes the reversible aldol cleavage of…”
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Alternative low-cost process for large-scale production of Bacillus thuringiensis in a simple and novel culture system by Rojas, Natalia L., Lewkowicz, Elizabeth S., Nobile, Matias L.

“…An industrial-scale, profitable method for production of the most widely used bioinsecticide, Bacillus thuringiensis (Bt), is challenging because of its…”
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Immobilized Escherichia coli BL21 as a Catalyst for the Synthesis of Adenine and Hypoxanthine Nucleosides by Trelles, Jorge A., Bentancor, Leticia, Schoijet, Alejandra, Porro, Silvia, Lewkowicz, Elizabeth S., Sinisterra, José V., Iribarren, Adolfo M.

“…Different supports, such as alginate, agar, agarose, and polyacrylamide, were used to immobilize Escherichia coli BL 21 by entrapment techniques. The…”
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A comparative study on phosphotransferase activity of acid phosphatases from Raoultella planticola and Enterobacter aerogenes on nucleosides, sugars, and related compounds by Médici, Rosario, Garaycoechea, Juan I., Valino, Ana L., Pereira, Claudio A., Lewkowicz, Elizabeth S., Iribarren, Adolfo M.

“…Natural and modified nucleoside-5′-monophosphates and their precursors are valuable compounds widely used in biochemical studies. Bacterial nonspecific acid…”
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Self-sufficient redox biotransformation of lignin-related benzoic acids with Aspergillus flavus by Palazzolo, Martín A, Mascotti, María L, Lewkowicz, Elizabeth S, Kurina-Sanz, Marcela

“…Aromatic carboxylic acids are readily obtained from lignin in biomass processing facilities. However, efficient technologies for lignin valorization are…”
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Use of Citrobacter koseri whole cells for the production of arabinonucleosides: A larger scale approach by Nóbile, Matías, Médici, Rosario, Terreni, Marco, Lewkowicz, Elizabeth S., Iribarren, Adolfo M.

“…► C. koseri cells catalyzed the transglycosylation of arabinonucleosides. ► Fludarabine, vidarabine and diaminopurine arabinoside were obtained in good yields…”
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Organocatalytic synthesis of novel purine and pyrimidine acyclic nucleosides by Palazzolo, Martín A., Pérez-Sánchez, María, Iribarren, Adolfo M., Lewkowicz, Elizabeth S., Domínguez de María, Pablo

“…Organocatalysis is assessed for the first time in the synthesis of purine and pyrimidine acyclic nucleosides providing high yields and straightforward work-up…”
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Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts by Médici, Rosario, Iribarren, Adolfo M., Lewkowicz, Elizabeth S.

“…The synthesis of the anti leukemic agent 9-β-d-arabinofuranosylguanine employing two whole cell biocatalysts is reported. Unlike the preparation of other…”
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Arthrobacter oxydans as a biocatalyst for purine deamination by Médici, Rosario, Lewkowicz, Elizabeth S, Iribarren, Adolfo M

“…Deaminases are enzymes that catalyze the hydrolysis of amino groups of nucleosides or their bases. Because these enzymes play important roles in nucleotide…”
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Microbial hydrolysis of acetylated nucleosides by PANERO, Julieta, TRELLES, Jorge, RODANO, Valeria, MONTSERRAT, Javier M, IGLESIAS, Luis E, LEWKOWICZ, Elizabeth S, IRIBARREN, Adolfo M

“…Enzymatic hydrolysis of acetylated nucleosides using microbial whole cells has been carried out for the first time. Unlike Candida antarctica B…”
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Aldehyde-hydrate equilibrium in nucleobase 2-oxoethyl derivatives: An NMR, ESI-MS and theoretical study by Nigro, Mariano J., Brardinelli, Juan I., Lewkowicz, Elizabeth S., Iribarren, Adolfo M., Laurella, Sergio L.

“…N-2-oxoethyl derivatives of nucleobases are useful starting materials for the preparation of potentially active nucleoside analogues. The 1HNMR, 13CNMR, DEPT…”
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An improved microbial synthesis of purine nucleosides by LEWKOWICZ, Elizabeth S, MARTINEZ, Natalia, ROGERT, Maria C, PORRO, Silvia, IRIBARREN, Adolfo M

“…E. coliBL21 synthesized purine nucleosides from pyrimidine ones. A 94% yield of adenosine from uridine was reached within 1 h.[PUBLICATION ABSTRACT]…”
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Keto‐Enol Tautomerism in Nucleobase‐Substituted Aldols by Nigro, Mariano J., Iribarren, Adolfo M., Laurella, Sergio L., Lewkowicz, Elizabeth S.

“…Acyclic nucleosides, which exhibit significant antiviral activity, are usually synthesised using traditional chemical strategies. However, the efficient and…”
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