Search Results - "Lewis‐Tuffin, Laura J."

Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations by Patel, Tulsi, Carnwath, Troy P., Wang, Xue, Allen, Mariet, Lincoln, Sarah J., Lewis‐Tuffin, Laura J., Quicksall, Zachary S., Lin, Shu, Tutor‐New, Frederick Q., Ho, Charlotte C.G., Min, Yuhao, Malphrus, Kimberly G., Nguyen, Thuy T., Martin, Elizabeth, Garcia, Cesar A., Alkharboosh, Rawan M., Grewal, Sanjeet, Chaichana, Kaisorn, Wharen, Robert, Guerrero‐Cazares, Hugo, Quinones‐Hinojosa, Alfredo, Ertekin‐Taner, Nilüfer

“…Microglia have fundamental roles in health and disease; however, effects of age, sex, and genetic factors on human microglia have not been fully explored. We…”
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The Physiology of Human Glucocorticoid Receptor β (hGRβ) and Glucocorticoid Resistance by LEWIS-TUFFIN, LAURA J., CIDLOWSKI, JOHN A.

“…:  The development of glucocorticoid (GC) resistance is a serious problem that complicates the treatment of immune‐related diseases, such as asthma, ulcerative…”
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Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype by Lewis-Tuffin, Laura J, Rodriguez, Fausto, Giannini, Caterina, Scheithauer, Bernd, Necela, Brian M, Sarkaria, Jann N, Anastasiadis, Panos Z

“…Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis,…”
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Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion by Huveldt, Deborah, Lewis-Tuffin, Laura J, Carlson, Brett L, Schroeder, Mark A, Rodriguez, Fausto, Giannini, Caterina, Galanis, Evanthia, Sarkaria, Jann N, Anastasiadis, Panos Z

“…Anti-VEGF antibody therapy with bevacizumab provides significant clinical benefit in patients with recurrent glioblastoma multiforme (GBM). Unfortunately,…”
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VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx by Ngok, Siu P, Geyer, Rory, Liu, Miaoliang, Kourtidis, Antonis, Agrawal, Sudesh, Wu, Chuanshen, Seerapu, Himabindu Reddy, Lewis-Tuffin, Laura J, Moodie, Karen L, Huveldt, Deborah, Marx, Ruth, Baraban, Jay M, Storz, Peter, Horowitz, Arie, Anastasiadis, Panos Z

“…Vascular endothelial growth factor (VEGF) and Ang1 (Angiopoietin-1) have opposing effects on vascular permeability, but the molecular basis of these effects is…”
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APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids by Zhao, Jing, Ikezu, Tadafumi C, Lu, Wenyan, Macyczko, Jesse R, Li, Yonghe, Lewis-Tuffin, Laura J, Martens, Yuka A, Ren, Yingxue, Zhu, Yiyang, Asmann, Yan W, Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun

“…The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD); however, how it modulates brain homeostasis is not clear…”
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Human Glucocorticoid Receptor β Binds RU-486 and Is Transcriptionally Active by Lewis-Tuffin, Laura J, Jewell, Christine M, Bienstock, Rachelle J, Collins, Jennifer B, Cidlowski, John A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Protein Kinase D1-mediated Phosphorylations Regulate Vasodilator-stimulated Phosphoprotein (VASP) Localization and Cell Migration by Döppler, Heike R., Bastea, Ligia I., Lewis-Tuffin, Laura J., Anastasiadis, Panos Z., Storz, Peter

“…Enabled/Vasodilator-stimulated phosphoprotein (Ena/VASP) protein family members link actin dynamics and cellular signaling pathways. VASP localizes to regions…”
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Tau exhibits unique seeding properties in globular glial tauopathy by Chung, Dah-Eun Chloe, Carlomagno, Yari, Cook, Casey N, Jansen-West, Karen, Daughrity, Lillian, Lewis-Tuffin, Laura J, Castanedes-Casey, Monica, DeTure, Michael, Dickson, Dennis W, Petrucelli, Leonard

“…Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and…”
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A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma by Lin, Wan-Hsin, Feathers, Ryan W, Cooper, Lisa M, Lewis-Tuffin, Laura J, Chen, Jiaxiang, Sarkaria, Jann N, Anastasiadis, Panos Z

“…Glioblastomas (GBM) are aggressive tumors that lack effective treatments. Here, we show that the Rho family guanine nucleotide exchange factor Syx promotes GBM…”
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The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration by Dachsel, Justus C., Ngok, Siu P., Lewis-Tuffin, Laura J., Kourtidis, Antonis, Geyer, Rory, Johnston, Lauren, Feathers, Ryan, Anastasiadis, Panos Z.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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E-cadherin's dark side: Possible role in tumor progression by Rodriguez, Fausto J., Lewis-Tuffin, Laura J., Anastasiadis, Panos Z.

“…In the context of cancer, E-cadherin has traditionally been categorized as a tumor suppressor, given its essential role in the formation of proper…”
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Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus by Lewis-Tuffin, Laura J, Quinn, Patrick G, Chikaraishi, Dona M

“…In neurons and neuroendocrine cells, tyrosine hydroxylase (TH) gene expression is induced by stimuli that elevate cAMP, by depolarization, and by hypoxia…”
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Substitution of PINK1 Gly411 modulates substrate receptivity and turnover by Fiesel, Fabienne C, Fričová, Dominika, Hayes, Caleb S, Coban, Mathew A, Hudec, Roman, Bredenberg, Jenny M, Broadway, Benjamin J, Markham, Briana N, Yan, Tingxiang, Boneski, Paige K, Fiorino, Gabriella, Watzlawik, Jens O, Hou, Xu, McCarty, Arthur M, Lewis-Tuffin, Laura J, Zhong, Jun, Madden, Benjamin J, Ordureau, Alban, An, Heeseon, Puschmann, Andreas, Wszolek, Zbigniew K, Ross, Owen A, Harper, J Wade, Caulfield, Thomas R, Springer, Wolfdieter

“…The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils…”
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The AD tau core spontaneously self-assembles and recruits full-length tau to filaments by Carlomagno, Yari, Manne, Sireesha, DeTure, Michael, Prudencio, Mercedes, Zhang, Yong-Jie, Hanna Al-Shaikh, Rana, Dunmore, Judith A., Daughrity, Lillian M., Song, Yuping, Castanedes-Casey, Monica, Lewis-Tuffin, Laura J., Nicholson, Katharine A., Wszolek, Zbigniew K., Dickson, Dennis W., Fitzpatrick, Anthony W.P., Petrucelli, Leonard, Cook, Casey N.

“…Tau accumulation is a major pathological hallmark of Alzheimer’s disease (AD) and other tauopathies, but the mechanism(s) of tau aggregation remains unclear…”
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Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction by İş, Özkan, Wang, Xue, Reddy, Joseph S., Min, Yuhao, Yilmaz, Elanur, Bhattarai, Prabesh, Patel, Tulsi, Bergman, Jeremiah, Quicksall, Zachary, Heckman, Michael G., Tutor-New, Frederick Q., Can Demirdogen, Birsen, White, Launia, Koga, Shunsuke, Krause, Vincent, Inoue, Yasuteru, Kanekiyo, Takahisa, Cosacak, Mehmet Ilyas, Nelson, Nastasia, Lee, Annie J., Vardarajan, Badri, Mayeux, Richard, Kouri, Naomi, Deniz, Kaancan, Carnwath, Troy, Oatman, Stephanie R., Lewis-Tuffin, Laura J., Nguyen, Thuy, Carrasquillo, Minerva M., Graff-Radford, Jonathan, Petersen, Ronald C., Jr Jack, Clifford R., Kantarci, Kejal, Murray, Melissa E., Nho, Kwangsik, Saykin, Andrew J., Dickson, Dennis W., Kizil, Caghan, Allen, Mariet, Ertekin-Taner, Nilüfer

“…To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s…”
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Src family kinases differentially influence glioma growth and motility by Lewis-Tuffin, Laura J., Feathers, Ryan, Hari, Priya, Durand, Nisha, Li, Zhimin, Rodriguez, Fausto J., Bakken, Katie, Carlson, Brett, Schroeder, Mark, Sarkaria, Jann N., Anastasiadis, Panos Z.

“…Src-family kinase (SFK) signaling impacts multiple tumor-related properties, particularly in the context of the brain tumor glioblastoma. Consequently, the…”
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Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD8+ T-cell responses by Manna, Alak, Kellett, Timothy, Aulakh, Sonikpreet, Lewis-Tuffin, Laura J., Dutta, Navnita, Knutson, Keith, Chini, Eduardo, Pinilla-Ibarz, Javier, Lamanna, Nicole, Manochakian, Rami, Malavasi, Fabio, Sher, Taimur, Chanan-Khan, Asher A., Ailawadhi, Sikander, Paulus, Aneel

“…Patients with chronic lymphocytic leukemia (CLL) are characterized by monoclonal expansion of CD5+CD23+CD27+CD19+κ/λ+ B lymphocytes and are clinically noted to…”
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Ligand-Selective Targeting of the Glucocorticoid Receptor to Nuclear Subdomains Is Associated with Decreased Receptor Mobility by Schaaf, Marcel J. M, Lewis-Tuffin, Laura J, Cidlowski, John A

“…The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent…”
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Using anti-CD38 immunotherapy to enhance anti-tumor T-cell immunity in chronic lymphocytic leukemia (CLL) by Manna, Alak, Lewis-Tuffin, Laura J., Ailawadhi, Sikander, Chanan-Khan, Asher A., Paulus, Aneel

“…Abstract Increased CD38 expression on chronic lymphocytic leukemia (CLL) cells correlates with a negative prognosis, however, its utility as a therapeutic…”
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