Search Results - "Lewis, U.J."

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    Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides by Norstedt, G, Husman, B, Mode, A, Eneroth, P, Lewis, U J, Gustafsson, J A

    Published in Acta endocrinologica (Copenhagen) (01-03-1987)
    “…The sex differentiated binding 125I-human prolactin (PRL) to rat liver membranes was studied and the present results extend our previous studies on induction…”
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    Glycosylated Human Growth Hormone (hGH): A Novel 24 kDa hGH-N Variant by Haro, L.S., Lewis, U.J., Garcia, M., Bustamante, J., Martinez, A.O., Ling, N.C.

    “…We have identified a human pituitary protein as a novel glycosylated variant of hGH. Isolation of the denatured protein included separation of human pituitary…”
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    Human Growth Hormone Deletion Mutant (hGH44-191) Binds with High Affinity to Lactogenic Receptors but Not to Somatogenic Receptors by Haro, L.S., Singh, R.N.P., Lewis, U.J., Martinez, A.O., Galosy, S.S., Staten, N.R., Krivi, G.G.

    “…The carboxyl-terminal hGH fragment, hGH44–191, displays diabetogenic activity. To understand whether this biological activity is mediated through somatogenic…”
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    Glycosylated ovine prolactin by Lewis, Urban J., Rama N. P. Singh, Lewis, Loraine J., Seavey, Boyd K., Sinha, Yagya N.

    “…A modification of prolactin, in which the asparagine at position 31 carries a carbohydrate unit, was isolated from ovine pituitary glands. Sequence and amino…”
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    A recombinant-DNA-derived modification of human growth hormone (hGH44-191) with enhanced diabetogenic activity by Lewis, U J, Lewis, L J, Salem, M A, Staten, N R, Galosy, S S, Krivi, G G

    Published in Molecular and cellular endocrinology (01-06-1991)
    “…A modified human growth hormone (hGH) that lacks the first 43 residues of the intact hormone was prepared by recombinant-DNA technology. For preparative…”
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    Isolation and biochemical properties of four forms of glycosylated porcine prolactin by Sinha, Y N, DePaolo, L V, Haro, L S, Singh, R N, Jacobsen, B P, Scott, K E, Lewis, U J

    “…Four isoforms of glycosylated prolactin (G-pPRL) were isolated from porcine pituitary glands by affinity chromatography and concanavalin A-Sepharose, based…”
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    A lectin-binding immunoassay indicates a possible glycosylated growth hormone in the human pituitary gland by Sinha, Y N, Lewis, U J

    “…By means of a lectin binding immunoassay we detected a glycosylated human growth hormone-immunoreactive substance in the human pituitary gland. The assay…”
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    Antibodies to newly recognized murine 13-18 KDa pituitary peptides crossreact with growth hormone and prolactin from several species, including man by Sinha, Y N, Jacobsen, B P, Lewis, U J

    “…Recently we identified five novel peptides of Mr 13,000 to 18,000 (designated P13, P14, P16, P17, and P18 according to approximate Mr) in the anterior…”
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    Glycosylation abolishes an in vitro insulin-like action of prolactin by Frigeri, L G, Lewis, L J, Teguh, K, Lewis, U J

    “…Ovine prolactin stimulated 14C-CO2 production from labeled glucose in adipose tissue of hypophysectomized rats in vitro, an insulin-like activity…”
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    Altered proteolytic cleavage of human growth hormone as a result of deamidation by Lewis, U J, Singh, R N, Bonewald, L F, Seavey, B K

    Published in The Journal of biological chemistry (25-11-1981)
    “…The major desamido form of human growth hormone (hGH) results from deamidation of asparagine 152. Peptide mapping and amino acid sequencing were used in the…”
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    Somatomedin generating activity of the 20,000-dalton variant of human growth hormone by Spencer, E M, Lewis, L J, Lewis, U J

    Published in Endocrinology (Philadelphia) (01-10-1981)
    “…The 20,000-dalton variant of human growth hormone stimulated production of somatomedins in the hypophysectomized rat. Somatomedin activity was measured by a…”
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    Binding characteristics of a biologically active variant of human growth hormone (20K) to growth hormone and lactogen receptors by Sigel, M B, Thorpe, N A, Kobrin, M S, Lewis, U J, Vanderlaan, W P

    Published in Endocrinology (Philadelphia) (01-04-1981)
    “…The dose-dependent displacement characteristics of a biologically active 20,000 molecular weight human pituitary growth hormone variant (20K) and of human…”
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