Search Results - "Lewis, Tommy"

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture by Courchet, Julien, Lewis, Tommy L., Lee, Sohyon, Courchet, Virginie, Liou, Deng-Yuan, Aizawa, Shinichi, Polleux, Franck

“…The molecular mechanisms underlying the axon arborization of mammalian neurons are poorly understood but are critical for the establishment of functional…”
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Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease by Rangaraju, Vidhya, Lewis, Jr, Tommy L, Hirabayashi, Yusuke, Bergami, Matteo, Motori, Elisa, Cartoni, Romain, Kwon, Seok-Kyu, Courchet, Julien

“…Mitochondria play many important biological roles, including ATP production, lipid biogenesis, ROS regulation, and calcium clearance. In neurons, the…”
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MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size by Lewis, Tommy L., Kwon, Seok-Kyu, Lee, Annie, Shaw, Reuben, Polleux, Franck

“…Neurons display extreme degrees of polarization, including compartment-specific organelle morphology. In cortical, long-range projecting, pyramidal neurons…”
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Cellular and molecular mechanisms underlying axon formation, growth, and branching by Lewis, Tommy L, Courchet, Julien, Polleux, Franck

“…Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and…”
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Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo by Lewis, Tommy L., Turi, Gergely F., Kwon, Seok-Kyu, Losonczy, Attila, Polleux, Franck

“…The importance of mitochondria for neuronal function is evident by the large number of neurodegenerative diseases that have been associated with a disruption…”
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Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress by Toyama, Erin Quan, Herzig, Sébastien, Courchet, Julien, Lewis, Jr, Tommy L, Losón, Oliver C, Hellberg, Kristina, Young, Nathan P, Chen, Hsiuchen, Polleux, Franck, Chan, David C, Shaw, Reuben J

“…Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations, yet how these stimuli…”
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Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex by Ebrahimi-Fakhari, Darius, Saffari, Afshin, Wahlster, Lara, Di Nardo, Alessia, Turner, Daria, Lewis, Tommy L., Conrad, Christopher, Rothberg, Jonathan M., Lipton, Jonathan O., Kölker, Stefan, Hoffmann, Georg F., Han, Min-Joon, Polleux, Franck, Sahin, Mustafa

“…Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1…”
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Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy by Lee, Annie, Kondapalli, Chandana, Virga, Daniel M., Lewis, Tommy L., Koo, So Yeon, Ashok, Archana, Mairet-Coello, Georges, Herzig, Sebastien, Foretz, Marc, Viollet, Benoit, Shaw, Reuben, Sproul, Andrew, Polleux, Franck

“…During the early stages of Alzheimer’s disease (AD) in both mouse models and human patients, soluble forms of Amyloid-β 1–42 oligomers (Aβ42o) trigger loss of…”
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LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons by Kwon, Seok-Kyu, Sando, 3rd, Richard, Lewis, Tommy L, Hirabayashi, Yusuke, Maximov, Anton, Polleux, Franck

“…Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits…”
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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress by Toyama, Erin Quan, Herzig, Sébastien, Courchet, Julien, Lewis, Tommy L., Losón, Oliver C., Hellberg, Kristina, Young, Nathan P., Chen, Hsiuchen, Polleux, Franck, Chan, David C., Shaw, Reuben J.

“…Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA–linked disease mutations, yet how these stimuli…”
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Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation by Zehnder, Tamara, Petrelli, Francesco, Romanos, Jennifer, De Oliveira Figueiredo, Eva C., Lewis, Tommy L., Déglon, Nicole, Polleux, Franck, Santello, Mirko, Bezzi, Paola

“…The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in ensuring correct synaptogenesis. We show that mitochondrial…”
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Exercise and mitochondrial remodeling to prevent age-related neurodegeneration by O'Reilly, Colleen L, Miller, Benjamin F, Lewis, Jr, Tommy L

“…Healthy brain activity requires precise ion and energy management creating a strong reliance on mitochondrial function. Age-related neurodegeneration leads to…”
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Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo by Virga, Daniel M., Hamilton, Stevie, Osei, Bertha, Morgan, Abigail, Kneis, Parker, Zamponi, Emiliano, Park, Natalie J., Hewitt, Victoria L., Zhang, David, Gonzalez, Kevin C., Russell, Fiona M., Grahame Hardie, D., Prudent, Julien, Bloss, Erik, Losonczy, Attila, Polleux, Franck, Lewis, Tommy L.

“…Neuronal mitochondria play important roles beyond ATP generation, including Ca 2+ uptake, and therefore have instructive roles in synaptic function and…”
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Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice by Courchet, Virginie, Roberts, Amanda J., Meyer-Dilhet, Géraldine, Del Carmine, Peggy, Lewis, Tommy L., Polleux, Franck, Courchet, Julien

“…Recently, numerous rare de novo mutations have been identified in patients diagnosed with autism spectrum disorders (ASD). However, despite the predicted…”
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Emerging roles of mitochondria in synaptic transmission and neurodegeneration by Lee, Annie, Hirabayashi, Yusuke, Kwon, Seok-Kyu, Lewis, Tommy L, Polleux, Franck

“…•Neuronal mitochondria show compartment-specific morphology in dendrites and axons.•Genetically-encoded tools allow for monitoring of many mitochondrial…”
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A role for myosin VI in the localization of axonal proteins by Lewis, Jr, Tommy L, Mao, Tianyi, Arnold, Don B

“…In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and…”
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Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion by Kim, Su Yeon, Strucinska, Klaudia, Osei, Bertha, Han, Kihoon, Kwon, Seok-Kyu, Lewis, Jr, Tommy L

“…Neurons in the brain have a uniquely polarized structure consisting of multiple dendrites and a single axon generated from a cell body. Interestingly,…”
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Virus-Enabled Optimization and Delivery of the Genetic Machinery for Efficient Unnatural Amino Acid Mutagenesis in Mammalian Cells and Tissues by Zheng, Yunan, Lewis, Tommy L, Igo, Peter, Polleux, Franck, Chatterjee, Abhishek

“…Unnatural amino acid (UAA) mutagenesis of recombinant proteins in live mammalian cells requires coexpression of the mutant target, as well as an engineered…”
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Structure and Function of an Actin-Based Filter in the Proximal Axon by Balasanyan, Varuzhan, Watanabe, Kaori, Dempsey, William P., Lewis, Tommy L., Trinh, Le A., Arnold, Don B.

“…The essential organization of microtubules within neurons has been described; however, less is known about how neuronal actin is arranged and the functional…”
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Necroptosis increases with age in the brain and contributes to age-related neuroinflammation by Thadathil, Nidheesh, Nicklas, Evan H., Mohammed, Sabira, Lewis, Tommy L., Richardson, Arlan, Deepa, Sathyaseelan S.

“…Chronic inflammation of the central nervous system (CNS), termed neuroinflammation, is a hallmark of aging and a proposed mediator of cognitive decline…”
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