Search Results - "Lewis, S. C."

Increasing trends in regional heatwaves by Perkins-Kirkpatrick, S. E., Lewis, S. C.

“…Heatwaves have increased in intensity, frequency and duration, with these trends projected to worsen under enhanced global warming. Understanding regional…”
Get full text

Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium by Munir, Hafsa, Luu, Nguyet-Thin, Clarke, Lewis S C, Nash, Gerard B, McGettrick, Helen M

“…Mesenchymal stromal cells (MSC) are tissue-resident stromal cells capable of modulating immune responses, including leukocyte recruitment by endothelial cells…”
Get full text

Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface by Chimen, Myriam, Yates, Clara M, McGettrick, Helen M, Ward, Lewis S C, Harrison, Matthew J, Apta, Bonita, Dib, Lea H, Imhof, Beat A, Harrison, Paul, Nash, Gerard B, Rainger, G Ed

“…Two major monocyte subsets, CD14 CD16 (classical) and CD14 CD16 (nonclassical/intermediate), have been described. Each has different functions ascribed in its…”
Get full text

Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow by Thomas, Kate N, Lewis, Nia C S, Hill, Brigid G, Ainslie, Philip N

“…Duplex ultrasound is an evolving technology that allows the assessment of volumetric blood flow in the carotid and vertebral arteries during a range of…”
Get more information

Fully On-Chip MAC at 14 nm Enabled by Accurate Row-Wise Programming of PCM-Based Weights and Parallel Vector-Transport in Duration-Format by Narayanan, P., Ambrogio, S., Okazaki, A., Hosokawa, K., Tsai, H., Nomura, A., Yasuda, T., Mackin, C., Lewis, S. C., Friz, A., Ishii, M., Kohda, Y., Mori, H., Spoon, K., Khaddam-Aljameh, R., Saulnier, N., Bergendahl, M., Demarest, J., Brew, K. W., Chan, V., Choi, S., Ok, I., Ahsan, I., Lie, F. L., Haensch, W., Narayanan, V., Burr, G. W.

“…Hardware acceleration of deep learning using analog non-volatile memory (NVM) requires large arrays with high device yield, high accuracy Multiply-ACcumulate…”
Get full text

Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity by Lewis, Nia C S, Messinger, Laura, Monteleone, Brad, Ainslie, Philip N

“…We examined 1) whether global cerebral blood flow (CBF) would increase across a 6-h bout of normobaric poikilocapnic hypoxia and be mediated by a larger…”
Get full text

Stability of ENSO and its tropical Pacific teleconnections over the Last Millennium by Lewis, S. C, LeGrande, A. N

“…Determining past changes in the amplitude, frequency and teleconnections of the El Niño-Southern Oscillation (ENSO) is important for understanding its…”
Get full text

Regional cerebral blood flow in humans at high altitude: gradual ascent and 2 wk at 5,050 m by Willie, C K, Smith, K J, Day, T A, Ray, L A, Lewis, N C S, Bakker, A, Macleod, D B, Ainslie, P N

“…The interindividual variation in ventilatory acclimatization to high altitude is likely reflected in variability in the cerebrovascular responses to high…”
Get full text

Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury by Vliegenthart, ADB, Kimmitt, RA, Seymour, JH, Homer, NZ, Clarke, JI, Eddleston, M, Gray, A, Wood, DM, Dargan, PI, Cooper, JG, Antoine, DJ, Webb, DJ, Lewis, SC, Bateman, DN, Dear, JW

“…Acetaminophen (paracetamol‐APAP) is the most common cause of drug‐induced liver injury in the Western world. Reactive metabolite production by cytochrome P450…”
Get full text

Impact of hypocapnia and cerebral perfusion on orthostatic tolerance by Lewis, Nia C. S., Bain, Anthony R., MacLeod, David B., Wildfong, Kevin W., Smith, Kurt J., Willie, Christopher K., Sanders, Marit L., Numan, Tianne, Morrison, Shawnda A., Foster, Glen E., Stewart, Julian M., Ainslie, Philip N.

“…Key points Vasovagal syncope (a common form of fainting) is frequently associated with excessive breathing and leads to reductions in carbon dioxide…”
Get full text

HydroCoil Endovascular Aneurysm Occlusion and Packing Study (HELPS Trial): Procedural Safety and Operator-Assessed Efficacy Results by White, P.M, Lewis, S.C, Nahser, H, Sellar, R.J, Goddard, T, Gholkar, A, on behalf of HELPS Trial Collaboration

“…Coated coils have been in clinical use for several years without robust evidence to determine their safety/efficacy. The HydroCoil Endovascular Aneurysm…”
Get full text

Dose–response relationships between individual nonaspirin nonsteroidal anti‐inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta‐analysis based on individual patient data by Lewis, S. C., Langman, M. J. S., Laporte, Joan‐Ramon, Matthews, John N. S., Rawlins, Michael D., Wiholm, Bengt‐Erik

“…Aims To define by amalgamation of data obtained in contemporaneous case‐control studies, the risks associated with individual nonaspirin nonsteroidal…”
Get full text

Water vapour source impacts on oxygen isotope variability in tropical precipitation during Heinrich events by Lewis, S. C., LeGrande, A. N., Kelley, M., Schmidt, G. A.

“…Water isotope records such as speleothems provide extensive evidence of past tropical hydrological changes. During Heinrich events, isotopic changes in monsoon…”
Get full text

Cost-effectiveness analysis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial) by Gomes, M., Soares, M. O., Dumville, J. C., Lewis, S. C., Torgerson, D. J., Bodenham, A. R., Gough, M. J., Warlow, C. P.

“…Background: Health outcomes and costs are both important when deciding whether general (GA) or local (LA) anaesthesia should be used during carotid…”
Get full text

Prevalence of adults with brain arteriovenous malformations: a community based study in Scotland using capture-recapture analysis by Al-Shahi, R, Fang, J S Y, Lewis, S C, Warlow, C P

“…Objective: To conduct a population based study of brain arteriovenous malformation (AVM) prevalence. Methods: Multiple, overlapping sources of case…”
Get full text

Regulation of cerebral blood flow by arterial PCO2 independent of metabolic acidosis at 5050 m by Caldwell, Hannah G., Smith, Kurt J., Lewis, Nia C.S., Hoiland, Ryan L., Willie, Christopher K., Lucas, Samuel J.E., Stembridge, Michael, Burgess, Keith R., MacLeod, David B., Ainslie, Philip N.

“…Key points We investigated the influence of arterial PCO2 (PaCO2) with and without experimentally altered pH on cerebral blood flow (CBF) regulation at sea…”
Get full text

Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial by Sanders, R.D., Graham, C., Lewis, S.C., Bodenham, A., Gough, M.J., Warlow, C.

“…Nitrous oxide has been associated with increased vascular risk in the perioperative period. Here, we conducted a secondary analysis of the GALA trial to…”
Get full text

Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery by Smith, K. J., MacLeod, D., Willie, C. K., Lewis, N. C. S., Hoiland, R. L., Ikeda, K., Tymko, M. M., Donnelly, J., Day, T. A., MacLeod, N., Lucas, S. J. E., Ainslie, P. N.

“…Key points This study assessed the dynamic response of global cerebral blood flow (CBF) and cerebral fuel utilization during and following incremental supine…”
Get full text

Acute hypoxaemia and vascular function in healthy humans by Lewis, N. C. S., Bain, A. R., Wildfong, K. W., Green, D. J., Ainslie, P. N.

“…New Findings What is the central question of this study? Endothelium‐dependent flow‐mediated dilatation (FMD) is impaired during acute (60 min) exposure to…”
Get full text

How to spot bias and other potential problems in randomised controlled trials by Lewis, S C, Warlow, C P

Get full text