Search Results - "Lewis, Peter J."

Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD by Newing, Timothy P., Oakley, Aaron J., Miller, Michael, Dawson, Catherine J., Brown, Simon H. J., Bouwer, James C., Tolun, Gökhan, Lewis, Peter J.

“…In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to…”
Get full text

Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli by Xu, Zhi-Qiang, Jergic, Slobodan, Lo, Allen T. Y., Pradhan, Alok C., Brown, Simon H. J., Bouwer, James C., Ghodke, Harshad, Lewis, Peter J., Tolun, Gökhan, Oakley, Aaron J., Dixon, Nicholas E.

“…Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader…”
Get full text

Amino Alcohols as Potential Antibiotic and Antifungal Leads by Baker, Jennifer R, Cossar, Peter J, Blaskovich, Mark A T, Elliott, Alysha G, Zuegg, Johannes, Cooper, Matthew A, Lewis, Peter J, McCluskey, Adam

“…Five focused compound libraries (forty-nine compounds), based on prior studies in our laboratory were synthesized and screened for antibiotic and anti-fungal…”
Get full text

Molecular Architecture of the "Stressosome," a Signal Integration and Transduction Hub by Marles-Wright, Jon, Grant, Tim, Delumeau, Olivier, van Duinen, Gijs, Firbank, Susan J., Lewis, Peter J., Murray, James W., Newman, Joseph A., Quin, Maureen B., Race, Paul R., Rohou, Alexis, Tichelaar, Willem, van Heel, Marin, Lewis, Richard J.

“…A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of…”
Get full text

Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD by Larsen, Joachim S., Miller, Michael, Oakley, Aaron J., Dixon, Nicholas E., Lewis, Peter J.

“…Efficient control of transcription is essential in all organisms. In bacteria, where DNA replication and transcription occur simultaneously, the replication…”
Get full text

Bacterial Transcription as a Target for Antibacterial Drug Development by Ma, Cong, Yang, Xiao, Lewis, Peter J

“…Transcription, the first step of gene expression, is carried out by the enzyme RNA polymerase (RNAP) and is regulated through interaction with a series of…”
Get full text

Essential Biological Processes of an Emerging Pathogen: DNA Replication, Transcription, and Cell Division in Acinetobacter spp by ROBINSON, Andrew, BRZOSKA, Anthony J, TURNER, Kylie M, WITHERS, Ryan, HARRY, Elizabeth J, LEWIS, Peter J, DIXON, Nicholas E

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Stage-specific fluorescence intensity of GFP and mCherry during sporulation In Bacillus Subtilis by Doherty, Geoff P, Bailey, Kirra, Lewis, Peter J

“…Fluorescent proteins are powerful molecular biology tools that have been used to study the subcellular dynamics of proteins within live cells for well over a…”
Get full text

Small subunits of RNA polymerase: localization, levels and implications for core enzyme composition by DOHERTY, Geoff P, FOGG, Mark J, WILKINSON, Anthony J, LEWIS, Peter J

“…Bacterial RNA polymerases (RNAPs) contain several small auxiliary subunits known to co-purify with the core α, β and β' subunits. The ω subunit is conserved…”
Get full text

Single-step selection of drug resistant Acinetobacter baylyi ADP1 mutants reveals a functional redundancy in the recruitment of multidrug efflux systems by Brzoska, Anthony J, Hassan, Karl A, de Leon, Ellen J, Paulsen, Ian T, Lewis, Peter J

“…Members of the genus Acinetobacter have been the focus recent attention due to both their clinical significance and application to molecular biology. The soil…”
Get full text

Compartmentalization of transcription and translation in Bacillus subtilis by Lewis, Peter J., Thaker, Shail D., Errington, Jeffrey

“…Using fusions of green fluorescent protein to subunits of RNA polymerase (RNAP) and ribosomes, we have investigated the subcellular localization of the…”
Get full text

Protein‐protein interactions as antibiotic targets: A medicinal chemistry perspective by Cossar, Peter J., Lewis, Peter J., McCluskey, Adam

“…There are 27 small molecule protein‐protein interaction (PPI) modulators in Phase I, II, and III clinical trials targeting cancer, viruses, autoimmune…”
Get full text

Simulation and self-location by Lewis, Peter J., Fallis, Don

“…It is possible that you are living in a simulation—that your world is computer-generated rather than physical. But how likely is this scenario? Bostrom and…”
Get full text

The interaction between RNA polymerase and the elongation factor NusA by Yang, Xiao, Lewis, Peter J.

“…The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied…”
Get full text

Probability, Self‐Location, and Quantum Branching by Lewis, Peter J.

“…The main problem with the many‐worlds theory is that it is not clear how the notion of probability should be understood in a theory in which every possible…”
Get full text

The indeterminate present by Jhou, Nihel, Lewis, Peter J.

“…A non-solipsist form of presentness is usually thought to require the non-relative co-presentness of space-like separated events, where this requirement…”
Get full text

Small-Molecule Inhibitors of the NusB–NusE Protein–Protein Interaction with Antibiotic Activity by Cossar, Peter J, Abdel-Hamid, Mohammed K, Ma, Cong, Sakoff, Jennette A, Trinh, Trieu N, Gordon, Christopher P, Lewis, Peter J, McCluskey, Adam

“…The NusB–NusE protein–protein interaction (PPI) is critical to the formation of stable antitermination complexes required for stable RNA transcription in all…”
Get full text

Accuracy, conditionalization, and probabilism by Lewis, Peter J., Fallis, Don

“…Accuracy-based arguments for conditionalization and probabilism appear to have a significant advantage over their Dutch Book rivals. They rely only on the…”
Get full text

Toward a formal analysis of deceptive signaling by Fallis, Don, Lewis, Peter J.

“…Deception has long been an important topic in philosophy (see Augustine in Treatises on various subjects, New York, Fathers of the Church, 1952; Kant in…”
Get full text

Identification of inhibitors of bacterial RNA polymerase by Yang, Xiao, Ma, Cong, Lewis, Peter J.

“…•Inhibition of transcription initiation leads to cell death.•Interaction between RNA polymerase and a σ factor is required for transcription initiation in…”
Get full text