Search Results - "Lewis, Nuruddeen"

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties by Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.

“…Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of…”
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Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12 by Lewis, Nuruddeen D, Sia, Chang Ling, Kirwin, Katherine, Haupt, Sonya, Mahimkar, Gauri, Zi, Tong, Xu, Ke, Dooley, Kevin, Jang, Su Chul, Choi, Bryan, Boutin, Adam, Grube, Andrew, McCoy, Christine, Sanchez-Salazar, Jorge, Doherty, Michael, Gaidukov, Leonid, Estes, Scott, Economides, Kyriakos D, Williams, Douglas E, Sathyanarayanan, Sriram

“…The promise of IL12 as a cancer treatment has yet to be fulfilled with multiple tested approaches being limited by unwanted systemic exposure and unpredictable…”
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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance by Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram

“…Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical…”
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Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection by Hardbower, Dana M., Asim, Mohammad, Murray-Stewart, Tracy, Casero, Robert A., Verriere, Thomas, Lewis, Nuruddeen D., Chaturvedi, Rupesh, Piazuelo, M. Blanca, Wilson, Keith T.

“…We reported that arginase 2 (ARG2) deletion results in increased gastritis and decreased bacterial burden during Helicobacter pylori infection in mice. Our…”
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RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course by Lewis, Nuruddeen D, Hill, Jonathan D, Juchem, Kathryn W, Stefanopoulos, Dimitria E, Modis, Louise K

“…Abstract The role of microglia and monocyte-derived macrophages in experimental autoimmune encephalomyelitis pathogenesis has been controversial. To gain…”
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Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production by Chaturvedi, Rupesh, Asim, Mohammad, Hoge, Svea, Lewis, Nuruddeen D, Singh, Kshipra, Barry, Daniel P, de Sablet, Thibaut, Piazuelo, M. Blanca, Sarvaria, Aditya R, Cheng, Yulan, Closs, Ellen I, Casero, Robert A, Gobert, Alain P, Wilson, Keith T

“…Background & Aims Helicobacter pylori –induced immune responses fail to eradicate the bacterium. Nitric oxide (NO) can kill H pylori . However, translation of…”
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A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo by Lewis, Nuruddeen D, Patnaude, Lori A, Pelletier, Josephine, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan D, Stefanopoulos, Dimitria E, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R, Modis, Louise K

“…GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an important role in the regulation of bile acid synthesis, lipid…”
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Arginase II Restricts Host Defense to Helicobacter pylori by Attenuating Inducible Nitric Oxide Synthase Translation in Macrophages by Lewis, Nuruddeen D, Asim, Mohammad, Barry, Daniel P, Singh, Kshipra, de Sablet, Thibaut, Boucher, Jean-Luc, Gobert, Alain P, Chaturvedi, Rupesh, Wilson, Keith T

“…Helicobacter pylori infection of the stomach causes peptic ulcer disease and gastric cancer. Despite eliciting a vigorous immune response, the bacterium…”
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CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells by Lewis, Nuruddeen D, Muthukumarana, Akalushi, Fogal, Steven E, Corradini, Laura, Stefanopoulos, Dimitria E, Adusumalli, Prathima, Pelletier, Josephine, Panzenbeck, Mark, Berg, Karen, Canfield, Melissa, Cook, Brian N, Razavi, Hossein, Kuzmich, Daniel, Anderson, Shawn, Allard, Devan, Harrison, Paul, Grimaldi, Christine, Souza, Donald, Harcken, Christian, Fryer, Ryan M, Modis, Louise K, Brown, Maryanne L

“…Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of…”
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Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3 by Lewis, Nuruddeen D, Haxhinasto, Sokol A, Anderson, Shawn M, Stefanopoulos, Dimitria E, Fogal, Steven E, Adusumalli, Prathima, Desai, Sudha N, Patnaude, Lori A, Lukas, Susan M, Ryan, Kelli R, Slavin, Anthony J, Brown, Maryanne L, Modis, Louise K

“…Sphingosine-1-phosphate (S1P) receptors are critical for lymphocyte egress from secondary lymphoid organs, and S1P receptor modulators suppress lymphocyte…”
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Helicobacter pylori induces ERK-dependent formation of a phospho-c-fos.c-jun activator protein-1 complex that causes apoptosis in macrophages by Asim, Mohammad, Chaturvedi, Rupesh, Hoge, Svea, Lewis, Nuruddeen, Singh, Kshipra, Barry, Daniel, Algood, Holly, de Sablet, Thibaut, Gobert, Alain, Wilson, Keith

“…Macrophages are essential components of innate immunity, and apoptosis of these cells impairs mucosal defense to microbes. Helicobacter pylori is a gastric…”
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Helicobacter pylori Induces ERK-dependent Formation of a Phospho-c-Fos·c-Jun Activator Protein-1 Complex That Causes Apoptosis in Macrophages by Asim, Mohammad, Chaturvedi, Rupesh, Hoge, Svea, Lewis, Nuruddeen D., Singh, Kshipra, Barry, Daniel P., Algood, Holly S., de Sablet, Thibaut, Gobert, Alain P., Wilson, Keith T.

“…Macrophages are essential components of innate immunity, and apoptosis of these cells impairs mucosal defense to microbes. Helicobacter pylori is a gastric…”
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Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II by Lewis, Nuruddeen D, Asim, Mohammad, Barry, Daniel P, de Sablet, Thibaut, Singh, Kshipra, Piazuelo, M Blanca, Gobert, Alain P, Chaturvedi, Rupesh, Wilson, Keith T

“…Helicobacter pylori infection persists for the life of the host due to the failure of the immune response to eradicate the bacterium. Determining how H. pylori…”
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The Apolipoprotein E-Mimetic Peptide COG112 Inhibits NF-κB Signaling, Proinflammatory Cytokine Expression, and Disease Activity in Murine Models of Colitis by Singh, Kshipra, Chaturvedi, Rupesh, Barry, Daniel P., Coburn, Lori A., Asim, Mohammad, Lewis, Nuruddeen D., Piazuelo, M. Blanca, Washington, M. Kay, Vitek, Michael P., Wilson, Keith T.

“…Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, is a source of substantial morbidity and remains difficult to treat…”
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L-Arginine Availability Regulates Inducible Nitric Oxide Synthase-Dependent Host Defense against Helicobacter pylori by Chaturvedi, Rupesh, Asim, Mohammad, Lewis, Nuruddeen D, Algood, Holly M. Scott, Cover, Timothy L, Kim, Preston Y, Wilson, Keith T

“…Helicobacter pylori infection of the stomach causes an active immune response that includes stimulation of inducible nitric oxide (NO) synthase (iNOS)…”
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Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection by Barry, Daniel P, Asim, Mohammad, Scull, Brooks P, Piazuelo, M Blanca, de Sablet, Thibaut, Lewis, Nuruddeen D, Coburn, Lori A, Singh, Kshipra, Ellies, Lesley G, Gobert, Alain P, Chaturvedi, Rupesh, Wilson, Keith T

“…Once acquired, Helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. Our previous studies indicate that…”
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Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1 by Gobert, Alain P, Asim, Mohammad, Piazuelo, M Blanca, Verriere, Thomas, Scull, Brooks P, de Sablet, Thibaut, Glumac, Ashley, Lewis, Nuruddeen D, Correa, Pelayo, Peek, Jr, Richard M, Chaturvedi, Rupesh, Wilson, Keith T

“…A strong cellular cross-talk exists between the pathogen Helicobacter pylori and high-output NO production. However, how NO and H. pylori interact to signal in…”
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Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response by Singh, Kshipra, Coburn, Lori A, Barry, Daniel P, Asim, Mohammad, Scull, Brooks P, Allaman, Margaret M, Lewis, Nuruddeen D, Washington, M Kay, Rosen, Michael J, Williams, Christopher S, Chaturvedi, Rupesh, Wilson, Keith T

“…L-Arginine (L-Arg) is a semiessential amino acid that has altered availability in human ulcerative colitis (UC), a form of inflammatory bowel disease, and is…”
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The Apolipoprotein E-mimetic Peptide COG112 Inhibits the Inflammatory Response to Citrobacter rodentium in Colonic Epithelial Cells by Preventing NF-κB Activation by Singh, Kshipra, Chaturvedi, Rupesh, Asim, Mohammad, Barry, Daniel P., Lewis, Nuruddeen D., Vitek, Michael P., Wilson, Keith T.

“…Inflammatory bowel disease arises from the interplay between luminal bacteria and the colonic mucosa. Targeted inhibition of pro-inflammatory pathways without…”
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709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure by Lewis, Nuruddeen, Sia, Chang Ling, Kirwin, Katherine, Haupt, Sonya, Mahimkar, Gauri, Zi, Tong, Xu, Ke, Dooley, Kevin, Jang, Su Chul, Choi, Bryan, Grube, Andrew, McCoy, Christine, Sanchez-Salazar, Jorge, Doherty, Michael, Estes, Scott, Economides, Kyriakos, Williams, Douglas, Sathyanaryanan, Sriram

“…BackgroundThe promise of Interleukin-12 as a cancer treatment has yet to be fulfilled with multiple tested approaches being limited by unwanted systemic…”
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