Search Results - "Lewis, Joseph J"

Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase by Edwards, Philip D, Andisik, Donald W, Bryant, Craig A, Ewing, Barbara, Gomes, Bruce, Lewis, Joseph J, Rakiewicz, Donna, Steelman, Gary, Strimpler, Ann, Trainor, Diane A, Tuthill, Paul A, Mauger, Russell C, Veale, Chris A, Wildonger, Richard A, Williams, Joseph C, Wolanin, Donald J, Zottola, Mark

“…Previously we had shown that tripeptidyl trifluoromethyl ketones (TFMKs) possessing an N-terminal diarylacylsulfonamide, such as ICI 200,880 and ICI 200,355,…”
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2-Bromo-3-(cyclohexyloxy)acrylaldehyde: An Isolable Enol Ether of Bromomalonaldehyde Suitable for Use in the Manufacture of Imidazolecarboxaldehydes by Connolly, Terrence J, Disharoon, Michael W, Dragan, Vladimir, Lewis, Joseph J, Wehrenberg, Peter, Zhao, Ralph

“…Enol ethers derived from 2-bromomalonaldehyde are useful intermediates for the preparation of functionalized imidazolecarboxaldehydes. Recent work in our group…”
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Mechanism of slow-binding inhibition of human leukocyte elastase by trifluoromethyl ketones by Stein, Ross L, Strimpler, Anne M, Edwards, Phillip D, Lewis, Joseph J, Mauger, Russel C, Schwartz, Jack A, Stein, Mark M, Trainor, D. Amy, Wildonger, Richard A, Zottola, Mark A

“…Kinetics of inhibition have been determined for the interaction of human leukocyte elastase (HLE) with two series of peptide trifluoromethyl ketones (TFMKs):…”
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N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  KATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Neilson, Kathleen L

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N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  KATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Kirkland, M, Neilson, Kathleen L

“…A subset of antiandrogen compounds, the N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides 1, were found to activate ATP sensitive potassium channels (KATP)…”
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Decision of the Commissioner of Internal Revenue with Regard to the Income Tax to Be Paid by Physicians by Lewis, Joseph J

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N -Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  K ATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J., Russell, Keith, Empfield, James R., Frank, Cathy A., Gibson, Keith H., Mayhugh, Daniel R., McLaren, Frances M., Shapiro, Howard S., Brown, Frederick J., Trainor, Diane A., Ceccarelli, Christopher, Lin, Margaret M., Masek, Brian B., Forst, Janet M., Harris, Robert J., Hulsizer, James M., Lewis, Joseph J., Silverman, Stuart M., Smith, Reed W., Warwick, Paul J., Kau, Sen T., Chun, Alexa L., Grant, Thomas L., Howe, Burton B., Li, Jack H., Trivedi, Shephali, Halterman, Tracy J., Yochim, Christopher, Dyroff, Martin C., Kirkland, M., Neilson, Kathleen L.

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N -Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  K ATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J., Russell, Keith, Empfield, James R., Frank, Cathy A., Gibson, Keith H., Mayhugh, Daniel R., McLaren, Frances M., Shapiro, Howard S., Brown, Frederick J., Trainor, Diane A., Ceccarelli, Christopher, Lin, Margaret M., Masek, Brian B., Forst, Janet M., Harris, Robert J., Hulsizer, James M., Lewis, Joseph J., Silverman, Stuart M., Smith, Reed W., Warwick, Paul J., Kau, Sen T., Chun, Alexa L., Grant, Thomas L., Howe, Burton B., Li, Jack H., Trivedi, Shephali, Halterman, Tracy J., Yochim, Christopher, Dyroff, Martin C., M.Kirkland, and, Neilson, Kathleen L.

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4-Hydroxyimino-4,5,6,7-tetrahydrobenzofurazan: A convenient synthesis and a literature correction by Lewis, Joseph J.

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Diphenyl cyancarbonimidate and dichlorodiphenoxymethane as synthons for the construction of heterocyclic systems of medicinal interest by Lee Webb, R., Eggleston, Drake S., Labaw, Clifford S., Lewis, Joseph J., Wert, K.

“…Simple high yield methods for the preparation of heterocyclic N‐cyanoguanidines (including the anti‐ulcer drug cimetidine), substituted triazoles,…”
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Functionalization of the 4(5)methyl group of imidazoles: A novel synthesis of substituted imidazoles by Webb, R. Lee, Lewis, Joseph J.

“…Acyl vinyl phosphonium salts react with amidines to form imidazolyl phosphonium salts. These imidazolyl salts can be readily converted to multifunctional…”
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Lincoln's Kalamazoo Address Against Extending Slavery by Quaife, M. M.

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Heterocycles from phosphonium salts: A facile method for modification of the 4(5)-methyl group of thiazoles by Lee Webb, R., Lam, Bing L., Lewis, Joseph J., Wellman, George R., Berkoff, Charles E.

“…Thiazolyl phosphonium salts, formed from the condensation of acyl vinyl phosphonium salts with thioamides and thiourea, are readily functionaitzed in high…”
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Barium Granuloma of the Rectum: An Uncommon Complicated of Barium Enema by LEWIS JR, JOSEPH W., KERSTEIN, MORRIS D., KOSS, NEAL

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