Search Results - "Lewis, Jared C."

Beyond the Second Coordination Sphere: Engineering Dirhodium Artificial Metalloenzymes To Enable Protein Control of Transition Metal Catalysis by Lewis, Jared C

“…Conspectus Transition metal catalysis is a powerful tool for chemical synthesis, a standard by which understanding of elementary chemical processes can be…”
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Metallopeptide catalysts and artificial metalloenzymes containing unnatural amino acids by Lewis, Jared C

“…•Metal–peptide hybrids have unique potential for catalysis.•Unnatural amino acids (UAAs) can be used to create novel hybrid catalysts.•Several methods have…”
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Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis by Andorfer, Mary C, Lewis, Jared C

“…Flavin-dependent halogenases (FDHs) catalyze the halogenation of organic substrates by coordinating reactions of reduced flavin, molecular oxygen, and…”
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First and second sphere interactions accelerate non-native N -alkylation catalysis by the thermostable, methanol-tolerant B 12 -dependent enzyme MtaC by Kumar, Amardeep, Yang, Xinhang, Li, Jianbin, Lewis, Jared C

“…The corrinoid protein MtaC, which is natively involved in methyl transferase catalysis, catalyzes -alkylation of aniline using ethyl diazoacetate. Our results…”
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Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation by Srivastava, Poonam, Yang, Hao, Ellis-Guardiola, Ken, Lewis, Jared C.

“…Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions…”
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Directed Evolution of Flavin-Dependent Halogenases for Site- and Atroposelective Halogenation of 3‑Aryl-4(3H)‑Quinazolinones via Kinetic or Dynamic Kinetic Resolution by Snodgrass, Harrison M., Mondal, Dibyendu, Lewis, Jared C.

“…In this study, we engineer a variant of the flavin-dependent halogenase RebH that catalyzes site- and atroposelective halogenation of…”
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Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation by Lewis, Jared C, Bergman, Robert G, Ellman, Jonathan A

“…Nitrogen heterocycles are present in many compounds of enormous practical importance, ranging from pharmaceutical agents and biological probes to electroactive…”
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Flavin-dependent halogenases catalyze enantioselective olefin halocyclization by Mondal, Dibyendu, Fisher, Brian F., Jiang, Yuhua, Lewis, Jared C.

“…Halocyclization of alkenes is a powerful bond-forming tool in synthetic organic chemistry and a key step in natural product biosynthesis, but catalyzing…”
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Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo by McIntosh, John A., Coelho, Pedro S., Farwell, Christopher C., Wang, Z. Jane, Lewis, Jared C., Brown, Tristan R., Arnold, Frances H.

“…Nitrogen activation: Though P450 enzymes are masters of oxygen activation and insertion into CH bonds, their ability to use nitrogen for the same purpose has…”
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Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C–H Functionalization by Durak, Landon J, Payne, James T, Lewis, Jared C

“…Engineered variants of rebeccamycin halogenase were used to selectively halogenate a number of biologically active aromatic compounds. Subsequent Pd-catalyzed…”
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Controlling the optical and catalytic properties of artificial metalloenzyme photocatalysts using chemogenetic engineering by Zubi, Yasmine S, Liu, Bingqing, Gu, Yifan, Sahoo, Dipankar, Lewis, Jared C

“…Visible light photocatalysis enables a broad range of organic transformations that proceed via single electron or energy transfer. Metal polypyridyl complexes…”
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Rh(I)-Catalyzed Alkylation of Quinolines and Pyridines via C−H Bond Activation by Lewis, Jared C, Bergman, Robert G, Ellman, Jonathan A

“…The scope of heterocycle ortho-alkylation has been dramatically expanded to include pharmaceutically important pyridines and quinolines, which contain only a…”
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Selective C–H bond functionalization using repurposed or artificial metalloenzymes by Upp, David M, Lewis, Jared C

“…•Progress, potential, and challenges facing catalytic CH bond functionalization is discussed.•The reactivity of natural enzymes toward synthetic reagents to…”
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A General Method for Artificial Metalloenzyme Formation through Strain-Promoted Azide-Alkyne Cycloaddition by Yang, Hao, Srivastava, Poonam, Zhang, Chen, Lewis, Jared C.

“…Strain‐promoted azide–alkyne cycloaddition (SPAAC) can be used to generate artificial metalloenzymes (ArMs) from scaffold proteins containing a…”
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Metal-responsive regulation of enzyme catalysis using genetically encoded chemical switches by Zubi, Yasmine S., Seki, Kosuke, Li, Ying, Hunt, Andrew C., Liu, Bingqing, Roux, Benoît, Jewett, Michael C., Lewis, Jared C.

“…Dynamic control over protein function is a central challenge in synthetic biology. To address this challenge, we describe the development of an integrated…”
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Rh(I)-Catalyzed Arylation of Heterocycles via C−H Bond Activation:  Expanded Scope through Mechanistic Insight by Lewis, Jared C, Berman, Ashley M, Bergman, Robert G, Ellman, Jonathan A

“…A practical, functional group tolerant method for the Rh-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is…”
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Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines by Berman, Ashley M, Lewis, Jared C, Bergman, Robert G, Ellman, Jonathan A

“…A Rh(I)-catalyzed direct arylation of pyridine and quinoline heterocycles has been developed. The method provides rapid entry into an important class of…”
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Controlling Non-Native Cobalamin Reactivity and Catalysis in the Transcription Factor CarH by Yang, Xinhang, Gerroll, Benjamin H. R, Jiang, Yuhua, Kumar, Amardeep, Zubi, Yasmine S, Baker, Lane A, Lewis, Jared C

“…Vitamin B12 derivatives catalyze a wide range of organic transformations, but B12-dependent enzymes are underutilized in biocatalysis relative to other…”
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Site-Selective C–H Halogenation Using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling by Fisher, Brian F, Snodgrass, Harrison M, Jones, Krysten A, Andorfer, Mary C, Lewis, Jared C

“…Enzymes are powerful catalysts for site-selective C–H bond functionalization. Identifying suitable enzymes for this task and for biocatalysis in general…”
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Di-Palladium Complexes are Active Catalysts for Mono-N-Protected Amino Acid-Accelerated Enantioselective C–H Functionalization by Gair, Joseph J, Haines, Brandon E, Filatov, Alexander S, Musaev, Djamaladdin G, Lewis, Jared C

“…The role of mono-protected amino acid (MPAA) ligands in accelerating enantioselective cyclopalladation and palladium-catalyzed C–H functionalization was…”
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