Search Results - "Lewis, Jamal S."

Dendritic cells in the host response to implanted materials by Keselowsky, Benjamin G, Lewis, Jamal S

“…Abstract The role of dendritic cells (DCs) and their targeted manipulation in the body’s response to implanted materials is an important and developing area of…”
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Vomocytosis of Cryptococcus neoformans cells from murine, bone marrow-derived dendritic cells by Pacifici, Noah, Cruz-Acuña, Melissa, Diener, Agustina, Tu, Allen, Senthil, Neeraj, Han, Hyunsoo, Lewis, Jamal S

“…Cryptococcus neoformans (CN) cells survive within the acidic phagolysosome of macrophages (MΦ) for extended times, then escape without impacting the viability…”
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Macrophage integrins modulate response to ultra-high molecular weight polyethylene particles and direct particle-induced osteolysis by Zaveri, Toral D, Dolgova, Natalia V, Lewis, Jamal S, Hamaker, Kiri, Clare-Salzler, Michael J, Keselowsky, Benjamin G

“…Abstract Aseptic loosening due to peri-prosthetic osteolysis is one of the primary causes for failure of artificial joint replacements. Implant-derived wear…”
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Toward Personalized Peptide-Based Cancer Nanovaccines: A Facile and Versatile Synthetic Approach by Kakwere, Hamilton, Ingham, Elizabeth S, Allen, Riley, Mahakian, Lisa M, Tam, Sarah M, Zhang, Hua, Silvestrini, Matthew T, Lewis, Jamal S, Ferrara, Katherine W

“…Personalized cancer vaccines (PCVs) are receiving attention as an avenue for cancer immunotherapy. PCVs employ immunogenic peptide epitopes capable of…”
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Vomocytosis: Too Much Booze, Base, or Calcium? by Cruz-Acuña, Melissa, Pacifici, Noah, Lewis, Jamal S

“…Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of…”
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A Multi-Fluorophore Staining Scheme for Identification and Quantification of Vomocytosis by Pacifici, Noah, Rojalin, Tatu, Carney, Randy P, Lewis, Jamal S

“…Vomocytosis is a process by which fungal pathogens, for instance, (CN), escape from the digestive phagolysosome of phagocytic cells after ingestion…”
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An Image Processing Algorithm for Facile and Reproducible Quantification of Vomocytosis by Senthil, Neeraj, Pacifici, Noah, Cruz-Acuña, Melissa, Diener, Agustina, Han, Hyunsoo, Lewis, Jamal S.

“…Vomocytosis is a process that occurs when internalized fungal pathogens escape from phagocytes without compromising the viability of the pathogen and the host…”
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Bioderived materials that disarm the gut mucosal immune system: Potential lessons from commensal microbiota by Harriman, Rian, Lewis, Jamal S.

“…Over the course of evolution, mammals and gut commensal microbes have adapted to coexist with each other. This homeostatic coexistence is dependent on an…”
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Engineering antigen-presenting cells for immunotherapy of autoimmunity by Smith, Clinton T., Wang, Zhenyu, Lewis, Jamal S.

“…[Display omitted] Autoimmune diseases are burdensome conditions that affect a significant fraction of the global population. The hallmark of autoimmune disease…”
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Special issue: Emerging scholars in biomaterials by Leach, J. Kent, Lewis, Jamal S.

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Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection by Tu, Allen B, Krishna, Gaddam, Smith, Kevin R, Lewis, Jamal S

“…Autoimmunity, allergy, and transplant rejection are a collection of chronic diseases that are currently incurable, drastically decrease patient quality of…”
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Stimuli‐Responsive Biomaterials for Vaccines and Immunotherapeutic Applications by Pacifici, Noah, Bolandparvaz, Amir, Lewis, Jamal S.

“…The immune system is the key target for vaccines and immunotherapeutic approaches aimed at blunting infectious diseases, cancer, autoimmunity, and implant…”
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Integrin-directed modulation of macrophage responses to biomaterials by Zaveri, Toral D, Lewis, Jamal S, Dolgova, Natalia V, Clare-Salzler, Michael J, Keselowsky, Benjamin G

“…Abstract Macrophages are the primary mediator of chronic inflammatory responses to implanted biomaterials, in cases when the material is either in particulate…”
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Intra-articular injection of flavopiridol-loaded microparticles for treatment of post-traumatic osteoarthritis by Sangsuwan, Rapeepat, Yik, Jasper H.N., Owen, Matthew, Liu, Gang-Yu, Haudenschild, Dominik R., Lewis, Jamal S.

“…Rapid joint clearance of small molecule drugs is the major limitation of current clinical approaches to osteoarthritis and its subtypes, including…”
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Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles by Allen, Riley P, Bolandparvaz, Amir, Ma, Jeffrey A, Manickam, Vishal A, Lewis, Jamal S

“…Use of biomaterials to spatiotemporally control the activation of immune cells is at the forefront of biomedical engineering research. As more biomaterial…”
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The roadmap to micro: Generation of micron‐sized polymeric particles using a commercial microfluidic system by Cruz‐Acuña, Melissa, Kakwere, Hamilton, Lewis, Jamal S.

“…Microfluidic‐assisted particle fabrication provides a route to circumvent the disadvantages associated with traditional methods of polymeric particle…”
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A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice by Yoon, Young Mee, Lewis, Jamal S., Carstens, Matthew R., Campbell-Thompson, Martha, Wasserfall, Clive H., Atkinson, Mark A., Keselowsky, Benjamin G.

“…Targeted delivery of self-antigens to the immune system in a mode that stimulates a tolerance-inducing pathway has proven difficult. To address this hurdle, we…”
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Biomaterial-based immunotherapeutic strategies for rheumatoid arthritis by Tu, Allen B., Lewis, Jamal S.

“…Rheumatoid arthritis (RA) is an extremely painful autoimmune disease characterized by chronic joint inflammation leading to the erosion of adjacent cartilage…”
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Lactate Exposure Promotes Immunosuppressive Phenotypes in Innate Immune Cells by Sangsuwan, Rapeepat, Thuamsang, Bhasirie, Pacifici, Noah, Allen, Riley, Han, Hyunsoo, Miakicheva, Svetlana, Lewis, Jamal S.

“…Introduction Lactate secreted by tumors is not just a byproduct, but rather an active modulator of immune cells. There are few studies aimed at investigating…”
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Microparticle surface modifications targeting dendritic cells for non-activating applications by Lewis, Jamal S, Zaveri, Toral D, Crooks, Charles P, Keselowsky, Benjamin G

“…Abstract Microparticulate systems for delivery of therapeutics to DCs for immunotherapy have gained attention recently. However, reports addressing the…”
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