Search Results - "Lewis, JW"

The orvinols and related opioids--high affinity ligands with diverse efficacy profiles by Lewis, John W, Husbands, Stephen M

“…The thevinols and orvinols derived from thebaine via the thebaine-methylvinyl ketone adduct (thevinone) were thoroughly investigated in the 1960's and 1970's…”
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Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist by Neilan, Claire L., Husbands, Stephen M., Breeden, Simon, Ko, M.C. (Holden), Aceto, Mario D., Lewis, John W., Woods, James H., Traynor, John R.

“…The development of buprenorphine as a treatment for opiate abuse and dependence has drawn attention to opioid ligands that have agonist actions followed by…”
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Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors by Zaveri, Nurulain, Polgar, Willma E, Olsen, Cris M, Kelson, Andrew B, Grundt, Peter, Lewis, John W, Toll, Lawrence

“…Nociceptin/orphanin FQ (N/OFQ) was recently identified as the endogenous ligand for the opioid-receptor like (ORL1) receptor. Although the ORL1 receptor shows…”
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Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine by Broadbear, J H, Sumpter, T L, Burke, T F, Husbands, S M, Lewis, J W, Woods, J H, Traynor, J R

“…The irreversible mu-opioid antagonists beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) are important pharmacological tools but have a…”
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Buprenorphine and methoclocinnamox: agonist and antagonist effects on respiratory function in rhesus monkeys by Kishioka, Shiroh, Paronis, Carol A, Lewis, John W, Woods, James H

“…Buprenorphine and methoclocinnamox are partial μ-opioid receptor agonists with potential use in the treatment of opioid abuse. The ability of these drugs to…”
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Structural Determinants of Efficacy for κ Opioid Receptors in the Orvinol Series:  7,7-Spiro Analogues of Buprenorphine by Husbands, Stephen M, Lewis, John W

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BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice by Broom, D C, Guo, L, Coop, A, Husbands, S M, Lewis, J W, Woods, J H, Traynor, J R

“…N-Cyclopropylmethyl-[7alpha,8alpha,2', 3']-cyclohexano-1'[S]-hydroxy-6,14-endo-ethenotetrahydronororip avine (BU48) is a novel, ring-constrained analog of…”
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Buprenorphine by Lewis, J W

“…Buprenorphine is a mixed agonist-antagonist with high affinity at both mu and kappa opiate receptors. Its pharmacological profile is determined primarily by…”
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Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice by Burke, T F, Woods, J H, Lewis, J W, Medzihradsky, F

“…The effects of the systemically active irreversible opioid receptor antagonist clocinnamox (C-CAM; 14 beta-(p-chlorocinnamoylamino)-7,8-dihydro-N-…”
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Methoclocinnamox : time course of changes in alfentanil-reinforced responding in rhesus monkeys by BRISCOE, R. J, WINGER, G, LEWIS, J. W, WOODS, J. H

“…Methoclocinnamox (MC-CAM) possesses initial partial micro-opioid agonist activity with subsequent long-lasting micro-antagonist effects. This profile of…”
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Clocinnamox: a novel, systemically-active, irreversible opioid antagonist by Comer, S D, Burke, T F, Lewis, J W, Woods, J H

“…The warm water (55 degrees C) tail-withdrawal procedure was used to assess the analgesic effects of the prototypic mu opioid agonists, morphine and fentanyl,…”
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In vivo determination of mu opioid receptor turnover in rhesus monkeys after irreversible blockade with clocinnamox by Zernig, G, Butelman, E R, Lewis, J W, Walker, E A, Woods, J H

“…In a warm-water tail withdrawal antinociception assay performed at 45, 50 and 55 degrees C in the rhesus monkey, the irreversible opioid antagonist clocinnamox…”
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Corticocortical connections of visual, sensorimotor, and multimodal processing areas in the parietal lobe of the macaque monkey by Lewis, James W., Van Essen, David C.

“…We studied the corticocortical connections of architectonically defined areas of parietal and temporoparietal cortex, with emphasis on areas in the…”
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Distinct Cortical Pathways for Processing Tool versus Animal Sounds by Lewis, James W, Brefczynski, Julie A, Phinney, Raymond E, Janik, John J, DeYoe, Edgar A

“…Human listeners can effortlessly categorize a wide range of environmental sounds. Whereas categorizing visual object classes (e.g., faces, tools, houses, etc.)…”
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Ring constrained analogues of the orvinols: The furanomorphides by Husbands, Stephen M., Breeden, Simon W., Grivas, Konstantinos, Lewis, John W.

“…A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays…”
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Mapping of architectonic subdivisions in the macaque monkey, with emphasis on parieto-occipital cortex by Lewis, James W., Van Essen, David C.

“…The intraparietal sulcus (IPS) of the macaque monkey contains numerous areas associated with different aspects of cortical function, including motor control as…”
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Carcinoid tumors of the thymus by Economopoulos, George C., Lewis, Joseph W., Lee, Min W., Silverman, Norman A.

“…Carcinoid tumors arising in the thymus are rare. Since Rosai and Higa in 1972 distinguished these neoplasms from thymomas, fewer than 100 cases have been…”
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The Porcine Bioprosthetic Heart Valve: Experience at 15 Years by Magilligan, Donald J., Lewis, Joseph W., Stein, Paul, Alam, Mohsin

“…The porcine bioprosthetic valve has been in use at Henry Ford Hospital since 1971. In this review, 980 patients with 1,081 porcine bioprosthetic valves were…”
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Human Brain Regions Involved in Recognizing Environmental Sounds by Lewis, James W., Wightman, Frederic L., Brefczynski, Julie A., Phinney, Raymond E., Binder, Jeffrey R., DeYoe, Edgar A.

“…To identify the brain regions preferentially involved in environmental sound recognition (comprising portions of a putative auditory ‘what’ pathway), we…”
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Can computed tomography of the chest stage lung cancer?—Yes and no by Lewis, Joseph W., Pearlberg, Jay L., Beute, Gordon H., Alpern, Michael, Kvale, Paul A., Gross, Barry H., Magilligan, Donald J.

“…To determine the accuracy of computed tomography (CT) of the chest in the staging of lung cancer, we studied 418 patients with primary pulmonary carcinoma…”
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