Search Results - "Lewis, Hal A."

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core by Sivaprakasam, Prasanna, Han, Xiaojun, Civiello, Rita L, Jacutin-Porte, Swanee, Kish, Kevin, Pokross, Matt, Lewis, Hal A, Ahmed, Nazia, Szapiel, Nicolas, Newitt, John A, Baldwin, Eric T, Xiao, Hong, Krause, Carol M, Park, Hyunsoo, Nophsker, Michelle, Lippy, Jonathan S, Burton, Catherine R, Langley, David R, Macor, John E, Dubowchik, Gene M

“…Glycogen synthase kinase-3 (GSK-3) has been proposed to play a crucial role in the pathogenesis of many diseases including cancer, stroke, bipolar disorders,…”
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Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop by Ehrhardt, Annette, Chung, W. Joon, Pyle, Louise C., Wang, Wei, Nowotarski, Krzysztof, Mulvihill, Cory M., Ramjeesingh, Mohabir, Hong, Jeong, Velu, Sadanandan E., Lewis, Hal A., Atwell, Shane, Aller, Steve, Bear, Christine E., Lukacs, Gergely L., Kirk, Kevin L., Sorscher, Eric J.

“…In this study, we present data indicating a robust and specific domain interaction between the cystic fibrosis transmembrane conductance regulator (CFTR) first…”
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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant by Atwell, Shane, Brouillette, Christie G., Conners, Kris, Emtage, Spencer, Gheyi, Tarun, Guggino, William B., Hendle, Jorg, Hunt, John F., Lewis, Hal A., Lu, Frances, Protasevich, Irina I., Rodgers, Logan A., Romero, Rich, Wasserman, Stephen R., Weber, Patricia C., Wetmore, Diana, Zhang, Feiyu F., Zhao, Xun

“…Upon removal of the regulatory insert (RI), the first nucleotide binding domain (NBD1) of human cystic fibrosis transmembrane conductance regulator (CFTR) can…”
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Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect by Lewis, Hal A., Nemer, Kathleen M., Chibnall, Rebecca J., Musiek, Amy C.

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Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form by Nelp, Micah T., Kates, Patrick A., Hunt, John T., Newitt, John A., Balog, Aaron, Maley, Derrick, Zhu, Xiao, Abell, Lynn, Allentoff, Alban, Borzilleri, Robert, Lewis, Hal A., Lin, Zeyu, Seitz, Steven P., Yan, Chunhong, Groves, John T.

“…For cancer cells to survive and proliferate, they must escape normal immune destruction. One mechanism by which this is accomplished is through immune…”
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The Tetranucleotide UCAY Directs the Specific Recognition of RNA by the Nova K-Homology 3 Domain by Jensen, Kirk B., Musunuru, Kiran, Lewis, Hal A., Burley, Stephen K., Darnell, Robert B.

“…The Nova family of proteins are target antigens in the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia and contain K-homology (KH)-type RNA…”
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Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors by Luo, Guanglin, Chen, Ling, Jacutin-Porte, Swanee, Han, Ying, Burton, Catherine R., Xiao, Hong, Krause, Carol M., Cao, Yang, Liu, Nengyin, Kish, Kevin, Lewis, Hal A., Macor, John E., Dubowchik, Gene M.

“…[Display omitted] In our continuing efforts to explore structure–activity relationships around the novel class of potent, isonicotinamide-based GSK3 inhibitors…”
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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors by Luo, Guanglin, Chen, Ling, Burton, Catherine R, Xiao, Hong, Sivaprakasam, Prasanna, Krause, Carol M, Cao, Yang, Liu, Nengyin, Lippy, Jonathan, Clarke, Wendy J, Snow, Kimberly, Raybon, Joseph, Arora, Vinod, Pokross, Matt, Kish, Kevin, Lewis, Hal A, Langley, David R, Macor, John E, Dubowchik, Gene M

“…GSK-3 is a serine/threonine kinase that has numerous substrates. Many of these proteins are involved in the regulation of diverse cellular functions, including…”
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5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors by Peese, Kevin M, Allard, Christopher W, Connolly, Timothy, Johnson, Barry L, Li, Chen, Patel, Manoj, Sorensen, Margaret E, Walker, Michael A, Meanwell, Nicholas A, McAuliffe, Brian, Minassian, Beatrice, Krystal, Mark, Parker, Dawn D, Lewis, Hal A, Kish, Kevin, Zhang, Ping, Nolte, Robert T, Simmermacher, Jean, Jenkins, Susan, Cianci, Christopher, Naidu, B. Narasimhulu

“…A series of 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives targeting the allosteric lens-epithelium-derived-growth-factor-p75 (LEDGF/p75)-binding site on…”
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Neutrophil‐predominant bullous pemphigoid induced by checkpoint inhibitors: A case series by Morris, Lisa M., Lewis, Hal A., Cornelius, Lynn A., Chen, David Y., Rosman, Ilana S.

“…Checkpoint inhibitors have been revolutionary in the treatment of metastatic melanoma, non‐small‐cell lung cancer, and renal cell carcinoma. By restricting…”
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Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers by Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark

“…Influenza nucleoprotein (NP) plays multiple roles in the virus life cycle, including an essential function in viral replication as an integral component of the…”
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Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains by Lewis, Hal A, Chen, Hua, Edo, Carme, Buckanovich, Ronald J, Yang, Yolanda YL, Musunuru, Kiran, Zhong, Ru, Darnell, Robert B, Burley, Stephen K

“…Background: Nova-1 and Nova-2 are related neuronal proteins that were initially cloned using antisera obtained from patients with the autoimmune neurological…”
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Pemphigus foliaceus in a patient with gastrointestinal stromal tumor treated with adjuvant imatinib mesylate by Lewis, Hal A, Chen, David Y, Rosman, Ilana S, Picus, Joel, Anadkat, Milan J

“…Pemphigus is an autoimmune bullous disease with a number of described associations, including medications, which have been grouped into three structural…”
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SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib by O'Hare, Thomas, Eide, Christopher A, Tyner, Jeffrey W, Corbin, Amie S, Wong, Matthew J, Buchanan, Sean, Holme, Kevin, Jessen, Katayoun A, Tang, Crystal, Lewis, Hal A, Romero, Richard D, Burley, Stephen K, Deininger, Michael W

“…Imatinib inhibits Bcr-Abl, the oncogenic tyrosine kinase that causes chronic myeloid leukemia. The second-line inhibitors nilotinib and dasatinib are effective…”
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Impact of the ΔF508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure by Lewis, Hal A., Zhao, Xun, Wang, Chi, Sauder, J. Michael, Rooney, Isabelle, Noland, Brian W., Lorimer, Don, Kearins, Margaret C., Conners, Kris, Condon, Brad, Maloney, Peter C., Guggino, William B., Hunt, John F., Emtage, Spencer

“…Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR), commonly the deletion of residue Phe-508 (ΔF508) in the…”
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Overuse of Magnetic Resonance Imaging in the Diagnosis and Treatment of Moderate to Severe Osteoarthritis by Sherman, Seth L, Gulbrandsen, Trevor R, Lewis, Hal A, Gregory, Martin H, Capito, Nicholas M, Gray, Aaron D, Bal, B Sonny

“…MRI in the evaluation of end-stage knee joint osteoarthritis (OA) is usually unnecessary when radiographic and clinical evidence of gonarthrosis is clear. The…”
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Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3xTG-AD Mice by Bennett, Rachel E, Esparza, Thomas J, Lewis, Hal A, Kim, Eddie, Mac Donald, Christine L, Sullivan, Patrick M, Brody, David L

“…ABSTRACTApolipoprotein E4 (APOE4) genotype is a risk factor for poor outcome after traumatic brain injury (TBI), particularly in young patients, but the…”
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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator by Lewis, Hal A, Buchanan, Sean G, Burley, Stephen K, Conners, Kris, Dickey, Mark, Dorwart, Michael, Fowler, Richard, Gao, Xia, Guggino, William B, Hendrickson, Wayne A, Hunt, John F, Kearins, Margaret C, Lorimer, Don, Maloney, Peter C, Post, Kai W, Rajashankar, Kanagalaghatta R, Rutter, Marc E, Sauder, J Michael, Shriver, Stephanie, Thibodeau, Patrick H, Thomas, Philip J, Zhang, Marie, Zhao, Xun, Emtage, Spencer

“…Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP‐binding cassette (ABC) transporter that functions as a chloride channel…”
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Sequence-Specific RNA Binding by a Nova KH Domain: Implications for Paraneoplastic Disease and the Fragile X Syndrome by Lewis, Hal A, Musunuru, Kiran, Jensen, Kirk B, Edo, Carme, Chen, Hua, Darnell, Robert B, Burley, Stephen K

“…The structure of a Nova protein K homology (KH) domain recognizing single-stranded RNA has been determined at 2.4 Å resolution. Mammalian Nova antigens (1 and…”
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SGX393 inhibits the CML mutant Bcr-Abl[superscript T315I] and preempts in vitro resistance when combined with nilotinib or dasatinib by O'Hare, Thomas, Eide, Christopher A., Tyner, Jeffrey W., Corbin, Amie S., Wong, Matthew J., Buchanan, Sean, Holme, Kevin, Jessen, Katayoun A., Tang, Crystal, Lewis, Hal A., Romero, Richard D., Burley, Stephen K., Deininger, Michael W.

“…Imatinib inhibits Bcr-Abl, the oncogenic tyrosine kinase that causes chronic myeloid leukemia. The second-line inhibitors nilotinib and dasatinib are effective…”
Get full text