Search Results - "Lewis, Gavin M."

Innate and Adaptive Immune Regulation During Chronic Viral Infections by Zuniga, Elina I, Macal, Monica, Lewis, Gavin M, Harker, James A

“…Chronic viral infections represent a unique challenge to the infected host. Persistently replicating viruses outcompete or subvert the initial antiviral…”
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Plasmacytoid Dendritic Cells Are Productively Infected and Activated through TLR-7 Early after Arenavirus Infection by Macal, Mónica, Lewis, Gavin M., Kunz, Stefan, Flavell, Richard, Harker, James A., Zúñiga, Elina I.

“…The antiviral response is largely mediated by dendritic cells (DCs), including conventional (c) DCs that function as antigen-presenting cells, and plasmacytoid…”
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Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis by Sohn, Sue J, Lewis, Gavin M, Winoto, Astar

“…The mitogen‐activated protein kinases (MAPKs) ERK1/2, p38, and JNK are thought to determine survival‐versus‐death fate in developing thymocytes. However, this…”
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Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection by Harker, James A., Lewis, Gavin M., Mack, Lauren, Zuniga, Elina I.

“…Multiple inhibitory molecules create a profoundly immunuosuppressive environment during chronic viral infections in humans and mice. Therefore, eliciting…”
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TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections by Lewis, Gavin M, Wehrens, Ellen J, Labarta-Bajo, Lara, Streeck, Hendrik, Zuniga, Elina I

“…Suppression of CD8 and CD4 T cells is a hallmark in chronic viral infections, including hepatitis C and HIV. While multiple pathways are known to inhibit CD8 T…”
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Constitutive but not inducible attenuation of transforming growth factor β signaling increases natural killer cell responses without directly affecting dendritic cells early after persistent viral infection by Lewis, Gavin M, Macal, Monica, Hesser, Charles R, Zuñiga, Elina I

“…Rapid innate responses to viral encounters are crucial to shaping the outcome of infection, from viral clearance to persistence. Transforming growth factor β…”
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TGF-[Beta] receptor maintains CD4 T helper cell identity during chronic viral infections by Lewis, Gavin M, Wehrens, Ellen J, Labarta-Bajo, Lara, Streeck, Hendrik, Zuniga, Elina I

“…Suppression of CD8 and CD4 T cells is a hallmark in chronic viral infections, including hepatitis C and HIV. While multiple pathways are known to inhibit CD8 T…”
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Abstract 2730: Beyond antibodies and CAR-T: Topologically-engineered, super-dimeric antibody-like molecules with dual Fc domains for trispecific, bivalent targeting of CD19, CD20, and Fcgamma receptors by Capon, Daniel J., Chan, Nelson L., Troitskaya, Larisa, Fomin, Marina, Edman, Ursula, Frank, Brendon, Capon, Benjamin Z., Law, Brian, Chapin, Steven J., Lewis, Gavin M., Gefter, Malcolm L., Punnonen, Juha

“…Background: Depletion of B cells has resulted in major therapeutic benefits in autoimmune diseases and hematological malignancies. Several FDA-approved B…”
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Transforming Growth Factor-beta mediated suppression of cellular response to chronic viral infection by Lewis, Gavin M

“…Chronic viral infections remain a global health burden. Here we study the role of immunosuppressive Transforming Growth Factor-Beta (TGFβ) signaling on the…”
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