Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability

Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability

[Display omitted] •Nanoparticle surface coating agents can be cytotoxic.•Not enough attention paid to their potential contribution to nanoparticles toxicity.•Long aliphatic chain surface coating agents are cytotoxic in general.•The cytotoxicity depends on chemical structure, cell line used, and incu...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology in vitro Vol. 29; no. 4; pp. 762 - 768
Main Authors: Zhang, Ying, Newton, Brandon, Lewis, Eybriunna, Fu, Peter P., Kafoury, Ramzi, Ray, Paresh C., Yu, Hongtao
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-06-2015
Subjects:
Aliphatic amines
Amines - chemistry
Amines - toxicity
Cell Line, Tumor
Cell Survival - drug effects
Cytotoxicity
Humans
Nanoparticle
Nanoparticles - toxicity
Nanostructures - chemistry
Nanostructures - toxicity
Organic Chemicals - toxicity
SDS
Surface coating agents
Toxicity Tests
OcBr
NP
TBP
SDS
HDA
Nanoparticle
TDPA
4-A
Surface coating agents
Cytotoxicity
CTAB
OA
MA
TPP
Aliphatic amines
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Nanoparticle surface coating agents can be cytotoxic.•Not enough attention paid to their potential contribution to nanoparticles toxicity.•Long aliphatic chain surface coating agents are cytotoxic in general.•The cytotoxicity depends on chemical structure, cell line used, and incubation time. Impact on health by nanomaterials has become a public concern with the great advances of nanomaterials for various applications. Surface coating agents are an integral part of nanoparticles, but not enough attention has been paid during toxicity tests of nanoparticles. As a result, there are inconsistent toxicity results for certain nanomaterials. In this study, we explored the cytotoxicity of eleven commonly used surface coating agents in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100μM. Two exposure time points, 2h and 24h, were employed for the study. Six of the eleven surface coating agents are cytotoxic, especially those surfactants with long aliphatic chains, both cationic (cetyltrimethylammonium bromide, oleylamine, tetraoctylammonium bromide, and hexadecylamine) and anionic (sodium dodecylsulfate). In addition, exposure time and the use of different cell lines also affect the cytotoxicity results. Therefore, factors such as cell lines used and exposure times must be considered when conducting toxicity tests or comparing cytotoxicity results.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2015.01.017