Search Results - "Lewis, Edward J"

ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth by Ward, George A, Lewis, Edward J, Ahn, Jong Sook, Johnson, Christopher N, Lyons, John F, Martins, Vanessa, Munck, Joanne M, Rich, Sharna J, Smyth, Tomoko, Thompson, Neil T, Williams, Pamela A, Wilsher, Nicola E, Wallis, Nicola G, Chessari, Gianni

“…Because of their roles in the evasion of apoptosis, inhibitor of apoptosis proteins (IAP) are considered attractive targets for anticancer therapy. Antagonists…”
Get full text

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP) by Tamanini, Emiliano, Buck, Ildiko M, Chessari, Gianni, Chiarparin, Elisabetta, Day, James E. H, Frederickson, Martyn, Griffiths-Jones, Charlotte M, Hearn, Keisha, Heightman, Tom D, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Peakman, Torren, Reader, Michael, Rich, Sharna J, Ward, George A, Williams, Pamela A, Wilsher, Nicola E

“…XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways…”
Get full text

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP by Chessari, Gianni, Buck, Ildiko M, Day, James E. H, Day, Philip J, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Miller, Darcey, Reader, Michael, Rees, David C, Rich, Sharna J, Tamanini, Emiliano, Vitorino, Marc, Ward, George A, Williams, Pamela A, Williams, Glyn, Wilsher, Nicola E, Woolford, Alison J.-A

“…Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptosis and pro-survival signaling pathways whose deregulation is often associated with…”
Get full text

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660) by Johnson, Christopher N, Ahn, Jong Sook, Buck, Ildiko M, Chiarparin, Elisabetta, Day, James E H, Hopkins, Anna, Howard, Steven, Lewis, Edward J, Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M, Page, Lee W, Peakman, Torren, Reader, Michael, Rich, Sharna J, Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T, Ward, George A, Williams, Pamela A, Wilsher, Nicola E, Chessari, Gianni

“…Inhibitor of apoptosis proteins (IAPs) are promising anticancer targets, given their roles in the evasion of apoptosis. Several peptidomimetic IAP antagonists,…”
Get full text

Measurement and Quantification of Diffusion-Induced Compositional Variations in Absence of Convective Mixing at Reservoir Conditions by Ratnakar, Ram R., Dindoruk, Birol, Odikpo, Greg, Lewis, Edward J.

“…We present numerical and experimental investigation on the existence of diffusion-induced compositional variations in a reservoir fluid in the absence of…”
Get full text

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models by Squires, Matthew, Ward, George, Saxty, Gordan, Berdini, Valerio, Cleasby, Anne, King, Peter, Angibaud, Patrick, Perera, Tim, Fazal, Lynsey, Ross, Douglas, Jones, Charlotte Griffiths, Madin, Andrew, Benning, Rajdeep K, Vickerstaffe, Emma, O'Brien, Alistair, Frederickson, Martyn, Reader, Michael, Hamlett, Christopher, Batey, Michael A, Rich, Sharna, Carr, Maria, Miller, Darcey, Feltell, Ruth, Thiru, Abarna, Bethell, Susanne, Devine, Lindsay A, Graham, Brent L, Pike, Andrew, Cosme, Jose, Lewis, Edward J, Freyne, Eddy, Lyons, John, Irving, Julie, Murray, Christopher, Newell, David R, Thompson, Neil T

“…We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine…”
Get full text

A Fragment-Derived Clinical Candidate for Antagonism of X‑Linked and Cellular Inhibitor of Apoptosis Proteins: 1‑(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl‑1H,2H,3H‑pyrrolo[3,2‑b]pyridin-1-yl)-2-[(2R,5R)‑5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660) by Johnson, Christopher N., Ahn, Jong Sook, Buck, Ildiko M., Chiarparin, Elisabetta, Day, James E. H., Hopkins, Anna, Howard, Steven, Lewis, Edward J., Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M., Page, Lee W., Peakman, Torren, Reader, Michael, Rich, Sharna J., Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T., Ward, George A., Williams, Pamela A., Wilsher, Nicola E., Chessari, Gianni

“…Inhibitor of apoptosis proteins (IAPs) are promising anticancer targets, given their roles in the evasion of apoptosis. Several peptidomimetic IAP antagonists,…”
Get full text

Doctor I Can't Breathe: 1104 May 29 4:55 PM- 5:15 PM by Lewis, Edward J.

Get full text

Abstract 3626: Development of inhibitors of the fibroblast growth factor receptor (FGFR) kinase using a fragment based approach by Squires, Matthew S., Perera, Timothy, Saxty, Gordon, Murray, Chris, King, Peter, Ward, George, Feltell, Ruth, Rich, Sharna, Angibaud, Patrik, Lewis, Edward J., Gilissen, Ron, Harada, Isobel, Fazal, Lynsey, Irving, Julie A., Batey, Mike A., Zhao, Yan, Newell, David R., Thompson, Neil T.

“…Abstract Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being…”
Get full text

Cardiovascular involvement in celiac disease by Ciaccio, Edward J, Lewis, Suzanne K, Biviano, Angelo B, Iyer, Vivek, Garan, Hasan, Green, Peter H

“…Celiac disease(CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small…”
Get full text

Romazarit. A potential disease-modifying antirheumatic drug by Self, Christopher R, Barber, William E, Machin, Peter J, Osbond, John M, Smithen, Carey E, Tong, Brian P, Wickens, James C, Bloxham, David P, Bradshaw, David

“…The synthesis of a series of substituted heterocyclic alkoxypropionic acids is described. They were evaluated for antiinflammatory effects in two animal models…”
Get full text