Search Results - "Lewis, E C"

Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis by Roemer, F W, Guermazi, A, Javaid, M K, Lynch, J A, Niu, J, Zhang, Y, Felson, D T, Lewis, C E, Torner, J, Nevitt, M C

“…To describe the natural history of subchondral bone marrow lesions (BMLs) in a sample of subjects with knee osteoarthritis (OA) or at risk of developing it…”
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association between sleep duration and obesity in older adults by Patel, S.R, Blackwell, T, Redline, S, Ancoli-Israel, S, Cauley, J.A, Hillier, T.A, Lewis, C.E, Orwoll, E.S, Stefanick, M.L, Taylor, B.C, Yaffe, K, Stone, K.L

“…Background: Reduced sleep has been reported to predict obesity in children and young adults. However, studies based on self-report have been unable to identify…”
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Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density by LaCroix, A. Z, Beck, T. J, Cauley, J. A, Lewis, C. E, Bassford, T, Jackson, R, Wu, G, Chen, Z

“…Summary Hip geometry measurements of outer diameter and buckling ratio at the intertrochanter and shaft of the hip dual energy X-ray absorptiometry (DXA) scan…”
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Author Correction: The evolution and international spread of extensively drug resistant Shigella sonnei by Mason, Lewis C. E., Greig, David R., Cowley, Lauren A., Partridge, Sally R., Martinez, Elena, Blackwell, Grace A., Chong, Charlotte E., De Silva, P. Malaka, Bengtsson, Rebecca J., Draper, Jenny L., Ginn, Andrew N., Sandaradura, Indy, Sim, Eby M., Iredell, Jonathan R., Sintchenko, Vitali, Ingle, Danielle J., Howden, Benjamin P., Lefèvre, Sophie, Njamkepo, Elisabeth, Weill, François-Xavier, Ceyssens, Pieter-Jan, Jenkins, Claire, Baker, Kate S.

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Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans by Wise, Barton L., Niu, Jingbo, Yang, Mei, Lane, Nancy E., Harvey, William, Felson, David T., Hietpas, Jean, Nevitt, Michael, Sharma, Leena, Torner, Jim, Lewis, C. E., Zhang, Yuqing

“…Objective We conducted a cross‐sectional study to describe the prevalence of tibiofemoral joint space narrowing (JSN) in medial and lateral compartments and…”
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Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors by Ryan, R M, Green, J, Williams, P J, Tazzyman, S, Hunt, S, Harmey, J H, Kehoe, S C, Lewis, C E

“…The efficacy of current anti-cancer gene therapies is limited by the inability of gene vectors to penetrate the poorly vascularized, hypoxic regions of tumors,…”
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Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors by Crowther, M., Brown, N. J., Bishop, E. T., Lewis, C. E.

“…Angiogenesis is the development of blood vessels from an existing vasculature. This process is fundamental to both physiological wound healing and the growth…”
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Body mass index as a phenotypic expression of adiposity: quantitative contribution of muscularity in a population-based sample by Heymsfield, S.B, Scherzer, R, Pietrobelli, A, Lewis, C.E, Grunfeld, C

“…Objective: Although widely applied as a phenotypic expression of adiposity in population and gene-search studies, body mass index (BMI) is also acknowledged to…”
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The re-emergence of sexually transmissible multidrug resistant Shigella flexneri 3a, England, United Kingdom by Mason, Lewis C E, Charles, Hannah, Thorley, Katie, Chong, Charlotte E, De Silva, P Malaka, Jenkins, Claire, Baker, Kate S

“…Shigellosis is an enteric infection that transmits through the faecal-oral route, which can occur during sex between men who have sex with men (MSM). Between…”
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Macrophages promote angiogenesis in human breast tumour spheroids in vivo by SINGLE, L, LEWIS, C. E, CORKE, K. P, REED, M. W. R, BROWN, N. J

“…An in vivo model has been established to study the role of macrophages in the initiation of angiogenesis by human breast tumour spheroids in vivo. The extent…”
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White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses by Simpson, J. E., Fernando, M. S., Clark, L., Ince, P. G., Matthews, F., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., Brayne, C., Shaw, P. J., Lewis, C. E., Wharton, S. B.

“…Hyperintense lesions are frequently identified in T2‐weighted magnetic resonance images (MRI) in the ageing brain. The pathological correlate and pathogenesis…”
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A genotype risk score predicts type 2 diabetes from young adulthood: the CARDIA study by Vassy, J. L., Durant, N. H., Kabagambe, E. K., Carnethon, M. R., Rasmussen-Torvik, L. J., Fornage, M., Lewis, C. E., Siscovick, D. S., Meigs, J. B.

“…Aims/hypothesis Genotype does not change over the life course and may thus facilitate earlier identification of individuals at high risk for type 2 diabetes…”
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Excess gains in weight and waist circumference associated with childbearing: The Coronary Artery Risk Development in Young Adults Study (CARDIA) by GUNDERSON, E. P, MURTAUGH, M. A, LEWIS, C. E, QUESENBERRY, C. P, WEST, D. S, SIDNEY, S

“…To examine the association of childbearing with weight and waist circumference (WC) changes, we compared women with and without pregnancies or births during…”
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The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies by Bingle, L., Brown, N. J., Lewis, C. E.

“…The role of macrophages in tumour growth and development is complex and multifaceted. Whilst there is limited evidence that tumour‐associated macrophages…”
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Changes in risk factors for cardiovascular disease by baseline weight status in young adults who maintain or gain weight over 15 years: the CARDIA study by Truesdale, K.P, Stevens, J, Lewis, C.E, Schreiner, P.J, Loria, C.M, Cai, J

“…Objectives: To examine whether changes in cardiovascular disease (CVD) risk factors differ by baseline weight status among young adults who maintained or…”
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A novel magnetic approach to enhance the efficacy of cell-based gene therapies by Muthana, M, Scott, S D, Farrow, N, Morrow, F, Murdoch, C, Grubb, S, Brown, N, Dobson, J, Lewis, C E

“…Attempts have been made to use various forms of cellular vectors to deliver therapeutic genes to diseased tissues like malignant tumours. However, this…”
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impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study by Norman, J.E, Bild, D, Lewis, C.E, Liu, K, Smith West, D

“…OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by…”
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Is obesity a risk factor for progressive radiographic knee osteoarthritis? by Niu, J., Zhang, Y. Q., Torner, J., Nevitt, M., Lewis, C. E., Aliabadi, P., Sack, B., Clancy, M., Sharma, L., Felson, D. T.

“…Objective To examine whether obesity increases the risk of progression of knee osteoarthritis (OA). Methods We used data from the Multicenter Osteoarthritis…”
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Visceral adipose tissue: relationships between single slice areas at different locations and obesity-related health risks by Shen, W, Punyanitya, M, Chen, J, Gallagher, D, Albu, J, Pi-Sunyer, X, Lewis, C.E, Grunfeld, C, Heymsfield, S.B, Heshka, S

“…Background: Visceral adipose tissue (VAT) is widely recognized as conveying the highest health risk in humans among the currently measurable adipose tissue…”
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Macrophages in gene therapy: cellular delivery vehicles and in vivo targets by Burke, B., Sumner, S., Maitland, N., Lewis, C. E.

“…The appearance and activation of macrophages are thought to be rapid events in the development of many pathological lesions, including malignant tumors,…”
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