Search Results - "Lewis, Cathryn M."

Polygenic risk scores: from research tools to clinical instruments by Lewis, Cathryn M, Vassos, Evangelos

“…Genome-wide association studies have shown unequivocally that common complex disorders have a polygenic genetic architecture and have enabled researchers to…”
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PRSice: Polygenic Risk Score software by Euesden, Jack, Lewis, Cathryn M, O'Reilly, Paul F

“…A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide…”
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Prospects for using risk scores in polygenic medicine by Lewis, Cathryn M, Vassos, Evangelos

“…Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction…”
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Cross-classification between self-rated health and health status: longitudinal analyses of all-cause mortality and leading causes of death in the UK by Mutz, Julian, Lewis, Cathryn M.

“…Risk stratification is an important public health priority that is central to clinical decision making and resource allocation. The aim of this study was to…”
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Uncovering the Genetic Architecture of Major Depression by McIntosh, Andrew M., Sullivan, Patrick F., Lewis, Cathryn M.

“…There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the…”
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Evaluation of polygenic prediction methodology within a reference-standardized framework by Pain, Oliver, Glanville, Kylie P, Hagenaars, Saskia P, Selzam, Saskia, Fürtjes, Anna E, Gaspar, Héléna A, Coleman, Jonathan R I, Rimfeld, Kaili, Breen, Gerome, Plomin, Robert, Folkersen, Lasse, Lewis, Cathryn M

“…The predictive utility of polygenic scores is increasing, and many polygenic scoring methods are available, but it is unclear which method performs best. This…”
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Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants by Persyn, Elodie, Hanscombe, Ken B., Howson, Joanna M. M., Lewis, Cathryn M., Traylor, Matthew, Markus, Hugh S.

“…Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three…”
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Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures by Mutz, Julian, Roscoe, Charlotte J, Lewis, Cathryn M

“…A greater understanding of the factors that are associated with favourable health may help increase longevity and healthy life expectancy. We examined…”
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A bidirectional relationship between depression and the autoimmune disorders - New perspectives from the National Child Development Study by Euesden, Jack, Danese, Andrea, Lewis, Cathryn M, Maughan, Barbara

“…Depression and the autoimmune disorders are comorbid-the two classes of disorders overlap in the same individuals at a higher frequency than chance. The immune…”
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Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies by Traylor, Matthew, Persyn, Elodie, Tomppo, Liisa, Klasson, Sofia, Abedi, Vida, Bakker, Mark K, Torres, Nuria, Li, Linxin, Bell, Steven, Rutten-Jacobs, Loes, Tozer, Daniel J, Griessenauer, Christoph J, Zhang, Yanfei, Pedersen, Annie, Sharma, Pankaj, Jimenez-Conde, Jordi, Rundek, Tatjana, Grewal, Raji P, Lindgren, Arne, Meschia, James F, Salomaa, Veikko, Havulinna, Aki, Kourkoulis, Christina, Crawford, Katherine, Marini, Sandro, Mitchell, Braxton D, Kittner, Steven J, Rosand, Jonathan, Dichgans, Martin, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Zand, Ramin, Ruigrok, Ynte, Rost, Natalia, Lemmens, Robin, Rothwell, Peter M, Anderson, Christopher D, Wardlaw, Joanna, Lewis, Cathryn M, Markus, Hugh S

“…The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide…”
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Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism by Luciano, Michelle, Hagenaars, Saskia P., Davies, Gail, Hill, W. David, Clarke, Toni-Kim, Shirali, Masoud, Harris, Sarah E., Marioni, Riccardo E., Liewald, David C., Fawns-Ritchie, Chloe, Adams, Mark J., Howard, David M., Lewis, Cathryn M., Gale, Catharine R., McIntosh, Andrew M., Deary, Ian J.

“…Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) 1 ; heritability estimated from twin…”
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Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts by Fabbri, Chiara, Hagenaars, Saskia P., John, Catherine, Williams, Alexander T., Shrine, Nick, Moles, Louise, Hanscombe, Ken B., Serretti, Alessandro, Shepherd, David J., Free, Robert C., Wain, Louise V., Tobin, Martin D., Lewis, Cathryn M.

“…Treatment-resistant depression (TRD) is a major contributor to the disability caused by major depressive disorder (MDD). Primary care electronic health records…”
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Examining the association between family status and depression in the UK Biobank by Giannelis, Alexandros, Palmos, Alish, Hagenaars, Saskia P., Breen, Gerome, Lewis, Cathryn M., Mutz, Julian

“…•Living with a spouse or partner was associated with reduced odds of lifetime depression.•No evidence of an association between having two children and…”
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Contribution of Common Genetic Variants to Antidepressant Response by Tansey, Katherine E, Guipponi, Michel, Hu, Xiaolan, Domenici, Enrico, Lewis, Glyn, Malafosse, Alain, Wendland, Jens R, Lewis, Cathryn M, McGuffin, Peter, Uher, Rudolf

“…Background Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a…”
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Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders by O'Brien, Heath E, Hannon, Eilis, Hill, Matthew J, Toste, Carolina C, Robertson, Matthew J, Morgan, Joanne E, McLaughlin, Gemma, Lewis, Cathryn M, Schalkwyk, Leonard C, Hall, Lynsey S, Pardiñas, Antonio F, Owen, Michael J, O'Donovan, Michael C, Mill, Jonathan, Bray, Nicholas J

“…Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to…”
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Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke by Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.

“…Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal…”
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Comorbid medical illness in bipolar disorder by Forty, Liz, Ulanova, Anna, Jones, Lisa, Jones, Ian, Gordon-Smith, Katherine, Fraser, Christine, Farmer, Anne, McGuffin, Peter, Lewis, Cathryn M., Hosang, Georgina M., Rivera, Margarita, Craddock, Nick

“…Individuals with a mental health disorder appear to be at increased risk of medical illness. To examine rates of medical illnesses in patients with bipolar…”
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Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations by Kamp, Michelle, Pain, Oliver, Lewis, Cathryn M, Ramsay, Michèle

“…Cardiovascular diseases (CVD) are a major health concern in Africa. Improved identification and treatment of high-risk individuals can reduce adverse health…”
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Combining clinical variables to optimize prediction of antidepressant treatment outcomes by Iniesta, Raquel, Malki, Karim, Maier, Wolfgang, Rietschel, Marcella, Mors, Ole, Hauser, Joanna, Henigsberg, Neven, Dernovsek, Mojca Zvezdana, Souery, Daniel, Stahl, Daniel, Dobson, Richard, Aitchison, Katherine J, Farmer, Anne, Lewis, Cathryn M, McGuffin, Peter, Uher, Rudolf

“…Abstract The outcome of treatment with antidepressants varies markedly across people with the same diagnosis. A clinically significant prediction of outcomes…”
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Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores by Folkersen, Lasse, Pain, Oliver, Ingason, Andrés, Werge, Thomas, Lewis, Cathryn M, Austin, Jehannine

“…To date, interpretation of genomic information has focused on single variants conferring disease risk, but most disorders of major public concern have a…”
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