Search Results - "Lewis, Antonia J"

The Discovery of I‑BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor by Gosmini, Romain, Nguyen, Van Loc, Toum, Jérôme, Simon, Christophe, Brusq, Jean-Marie G, Krysa, Gael, Mirguet, Olivier, Riou-Eymard, Alizon M, Boursier, Eric V, Trottet, Lionel, Bamborough, Paul, Clark, Hugh, Chung, Chun-wa, Cutler, Leanne, Demont, Emmanuel H, Kaur, Rejbinder, Lewis, Antonia J, Schilling, Mark B, Soden, Peter E, Taylor, Simon, Walker, Ann L, Walker, Matthew D, Prinjha, Rab K, Nicodème, Edwige

“…Through their function as epigenetic readers of the histone code, the BET family of bromodomain-containing proteins regulate expression of multiple genes of…”
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Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression by Jones, Katherine L, Beaumont, Dominic M, Bernard, Sharon G, Bit, Rino A, Campbell, Simon P, Chung, Chun-Wa, Cutler, Leanne, Demont, Emmanuel H, Dennis, Kate, Gordon, Laurie, Gray, James R, Haase, Michael V, Lewis, Antonia J, McCleary, Scott, Mitchell, Darren J, Moore, Susanne M, Parr, Nigel, Robb, Olivia J, Smithers, Nicholas, Soden, Peter E, Suckling, Colin J, Taylor, Simon, Walker, Ann L, Watson, Robert J, Prinjha, Rab K

“…The functions of the bromodomain and extra terminal (BET) family of proteins have been implicated in a wide range of diseases, particularly in the oncology and…”
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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs by Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.

“…Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing…”
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Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N‑Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype by Wellaway, Christopher R, Bamborough, Paul, Bernard, Sharon G, Chung, Chun-wa, Craggs, Peter D, Cutler, Leanne, Demont, Emmanuel H, Evans, John P, Gordon, Laurie, Karamshi, Bhumika, Lewis, Antonia J, Lindon, Matthew J, Mitchell, Darren J, Rioja, Inmaculada, Soden, Peter E, Taylor, Simon, Watson, Robert J, Willis, Rob, Woolven, James M, Wyspiańska, Beata S, Kerr, William J, Prinjha, Rab K

“…The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem…”
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Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening by Wellaway, Christopher R, Amans, Dominique, Bamborough, Paul, Barnett, Heather, Bit, Rino A, Brown, Jack A, Carlson, Neil R, Chung, Chun-wa, Cooper, Anthony W. J, Craggs, Peter D, Davis, Robert P, Dean, Tony W, Evans, John P, Gordon, Laurie, Harada, Isobel L, Hirst, David J, Humphreys, Philip G, Jones, Katherine L, Lewis, Antonia J, Lindon, Matthew J, Lugo, Dave, Mahmood, Mahnoor, McCleary, Scott, Medeiros, Patricia, Mitchell, Darren J, O’Sullivan, Michael, Le Gall, Armelle, Patel, Vipulkumar K, Patten, Chris, Poole, Darren L, Shah, Rishi R, Smith, Jane E, Stafford, Kayleigh A. J, Thomas, Pamela J, Vimal, Mythily, Wall, Ian D, Watson, Robert J, Wellaway, Natalie, Yao, Gang, Prinjha, Rab K

“…The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize…”
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GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family by Preston, Alex, Atkinson, Stephen J, Bamborough, Paul, Chung, Chun-wa, Gordon, Laurie J, Grandi, Paola, Gray, James R. J, Harrison, Lee A, Lewis, Antonia J, Lugo, David, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Rioja, Inmaculada, Seal, Jon, Taylor, Simon, Thesmar, Pierre, Wall, Ian D, Watson, Robert J, Woolven, James M, Demont, Emmanuel H

“…Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events…”
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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs by Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.

“…Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing…”
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