Search Results - "Lewinsohn David"

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection by Drain, Paul K, Bajema, Kristina L, Dowdy, David, Dheda, Keertan, Naidoo, Kogieleum, Schumacher, Samuel G, Ma, Shuyi, Meermeier, Erin, Lewinsohn, David M, Sherman, David R

“…Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a limited understanding of its clinical pathogenic spectrum of…”
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The status of tuberculosis vaccine development by Schrager, Lewis K, Vekemens, Johan, Drager, Nick, Lewinsohn, David M, Olesen, Ole F

“…Tuberculosis represents the leading global cause of death from an infectious agent. Controlling the tuberculosis epidemic thus represents an urgent global…”
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Polyfunctional CD4 + T Cells As Targets for Tuberculosis Vaccination by Lewinsohn, Deborah A, Lewinsohn, David M, Scriba, Thomas J

“…Tuberculosis (TB), caused by (Mtb), remains a leading cause of morbidity and mortality worldwide, despite the widespread use of the only licensed vaccine,…”
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children by Lewinsohn, David M., Leonard, Michael K., LoBue, Philip A., Cohn, David L., Daley, Charles L., Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A., Loeffler, Ann M., Mazurek, Gerald H., O'Brien, Richard J., Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M., Sterling, Timothy R., Warshauer, David M., Woods, Gail L.

“…Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical…”
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children by Lewinsohn, David M, Leonard, Michael K, LoBue, Philip A, Cohn, David L, Daley, Charles L, Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A, Loeffler, Ann M, Mazurek, Gerald H, O'Brien, Richard J, Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M, Sterling, Timothy R, Warshauer, David M, Woods, Gail L

“…Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of…”
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Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells by Harriff, Melanie J, Karamooz, Elham, Burr, Ansen, Grant, Wilmon F, Canfield, Elizabeth T, Sorensen, Michelle L, Moita, Luis F, Lewinsohn, David M

“…Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play…”
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Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8⁺ T cells by Harriff, Melanie J, Cansler, Meghan E, Toren, Katelynne Gardner, Canfield, Elizabeth T, Kwak, Stephen, Gold, Marielle C, Lewinsohn, David M

“…Mycobacterium tuberculosis (Mtb) is transmitted via inhalation of aerosolized particles. While alveolar macrophages are thought to play a central role in the…”
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Human mucosal associated invariant T cells detect bacterially infected cells by Gold, Marielle C, Cerri, Stefania, Smyk-Pearson, Susan, Cansler, Meghan E, Vogt, Todd M, Delepine, Jacob, Winata, Ervina, Swarbrick, Gwendolyn M, Chua, Wei-Jen, Yu, Yik Y L, Lantz, Olivier, Cook, Matthew S, Null, Megan D, Jacoby, David B, Harriff, Melanie J, Lewinsohn, Deborah A, Hansen, Ted H, Lewinsohn, David M

“…Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive…”
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MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis by Gold, Marielle C., Napier, Ruth J., Lewinsohn, David M.

“…Summary The intracellular pathogen Mycobacterium tuberculosis (Mtb) and its human host have long co‐evolved. Although the host cellular immune response is…”
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An Expanding Role for Environmental Microbes in Shaping the Immune Response to Infection with Mycobacterium tuberculosis by Lewinsohn, David M

“…Following extensive exploration of alternate mechanistic explanations such as the binding of peptides to HLA-II and the function and phenotype of the…”
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MAIT cells and microbial immunity by Meermeier, Erin W, Harriff, Melanie J, Karamooz, Elham, Lewinsohn, David M

“…Mucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial…”
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Donor Unrestricted T Cells: Linking innate and adaptive immunity by Soma, Shogo, Lewinsohn, Deborah A., Lewinsohn, David M.

“…Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse…”
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Tuberculosis Infectiousness and Host Susceptibility by Turner, Richard D., Chiu, Christopher, Churchyard, Gavin J., Esmail, Hanif, Lewinsohn, David M., Gandhi, Neel R., Fennelly, Kevin P.

“…The transmission of tuberculosis is complex. Necessary factors include a source case with respiratory disease that has developed sufficiently for Mycobacterium…”
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Co-dependents: MR1-restricted MAIT cells and their antimicrobial function by Gold, Marielle C., Lewinsohn, David M.

“…Mucosal-associated invariant T (MAIT) cells have an intrinsic capacity to recognize a broad microbial repertoire through their invariant T cell receptor, which…”
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MR1-dependent antigen presentation by Karamooz, Elham, Harriff, Melanie J., Lewinsohn, David M.

“…MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for…”
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T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells by McMurtrey, Curtis, Harriff, Melanie J, Swarbrick, Gwendolyn M, Duncan, Amanda, Cansler, Meghan, Null, Megan, Bardet, Wilfried, Jackson, Kenneth W, Lewinsohn, Deborah A, Hildebrand, William, Lewinsohn, David M

“…HLA-E is a non-conventional MHC Class I molecule that has been recently demonstrated to present pathogen-derived ligands, resulting in the TCR-dependent…”
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Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens by Meermeier, Erin W., Laugel, Bruno F., Sewell, Andrew K., Corbett, Alexandra J., Rossjohn, Jamie, McCluskey, James, Harriff, Melanie J., Franks, Tamera, Gold, Marielle C., Lewinsohn, David M.

“…Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by the HLA-Ib molecule MR1 through the exclusive use of a…”
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T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells by Lepore, Marco, Lewinsohn, Deborah A., Lewinsohn, David M.

“…•MR1 can present multiple distinct ligands to T cells.•Diverse Human MR1 restricted T cells recognise distinct microbial or self/tumour antigens.•Individual…”
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Ligand-dependent downregulation of MR1 cell surface expression by Salio, Mariolina, Awad, Wael, Veerapen, Natacha, Gonzalez-Lopez, Claudia, Kulicke, Corinna, Waithe, Dominic, Martens, Anne W. J., Lewinsohn, David M., Hobrath, Judith V., Cox, Liam R., Rossjohn, Jamie, Besra, Gurdyal S., Cerundolo, Vincenzo

“…The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cells. While MR1 egress to the cell surface…”
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Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine by Stylianou, Elena, Harrington-Kandt, Rachel, Beglov, Julia, Bull, Naomi, Pinpathomrat, Nawamin, Swarbrick, Gwendolyn M, Lewinsohn, Deborah A, Lewinsohn, David M, McShane, Helen

“…The development of a vaccine against tuberculosis (TB), a disease caused by , is urgently needed. The only currently available vaccine, BCG, has variable…”
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