Search Results - "Lewinsohn, A"

Polyfunctional CD4 + T Cells As Targets for Tuberculosis Vaccination by Lewinsohn, Deborah A, Lewinsohn, David M, Scriba, Thomas J

“…Tuberculosis (TB), caused by (Mtb), remains a leading cause of morbidity and mortality worldwide, despite the widespread use of the only licensed vaccine,…”
Get full text

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children by Lewinsohn, David M., Leonard, Michael K., LoBue, Philip A., Cohn, David L., Daley, Charles L., Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A., Loeffler, Ann M., Mazurek, Gerald H., O'Brien, Richard J., Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M., Sterling, Timothy R., Warshauer, David M., Woods, Gail L.

“…Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical…”
Get full text

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children by Lewinsohn, David M, Leonard, Michael K, LoBue, Philip A, Cohn, David L, Daley, Charles L, Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A, Loeffler, Ann M, Mazurek, Gerald H, O'Brien, Richard J, Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M, Sterling, Timothy R, Warshauer, David M, Woods, Gail L

“…Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of…”
Get full text

High expression of CD26 accurately identifies human bacteria‐reactive MR1‐restricted MAIT cells by Sharma, Prabhat K., Wong, Emily B., Napier, Ruth J., Bishai, William R., Ndung'u, Thumbi, Kasprowicz, Victoria O., Lewinsohn, Deborah A., Lewinsohn, David M., Gold, Marielle C.

“…Summary Mucosa‐associated invariant T (MAIT) cells express the semi‐invariant T‐cell receptor TRAV1–2 and detect a range of bacteria and fungi through the…”
Get full text

Human mucosal associated invariant T cells detect bacterially infected cells by Gold, Marielle C, Cerri, Stefania, Smyk-Pearson, Susan, Cansler, Meghan E, Vogt, Todd M, Delepine, Jacob, Winata, Ervina, Swarbrick, Gwendolyn M, Chua, Wei-Jen, Yu, Yik Y L, Lantz, Olivier, Cook, Matthew S, Null, Megan D, Jacoby, David B, Harriff, Melanie J, Lewinsohn, Deborah A, Hansen, Ted H, Lewinsohn, David M

“…Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive…”
Get full text

T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells by McMurtrey, Curtis, Harriff, Melanie J, Swarbrick, Gwendolyn M, Duncan, Amanda, Cansler, Meghan, Null, Megan, Bardet, Wilfried, Jackson, Kenneth W, Lewinsohn, Deborah A, Hildebrand, William, Lewinsohn, David M

“…HLA-E is a non-conventional MHC Class I molecule that has been recently demonstrated to present pathogen-derived ligands, resulting in the TCR-dependent…”
Get full text

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells by Jin, Haihong, Ladd, Nicole A., Peev, Andrew M., Swarbrick, Gwendolyn M., Cansler, Meghan, Null, Megan, Boughter, Christopher T., McMurtrey, Curtis, Nilsen, Aaron, Dobos, Karen M., Hildebrand, William H., Lewinsohn, Deborah A., Adams, Erin J., Lewinsohn, David M., Harriff, Melanie J.

“…MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early…”
Get full text

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells by Harriff, Melanie J., Wolfe, Lisa M., Swarbrick, Gwendolyn, Null, Megan, Cansler, Meghan E., Canfield, Elizabeth T., Vogt, Todd, Toren, Katelynne Gardner, Li, Wei, Jackson, Mary, Lewinsohn, Deborah A., Dobos, Karen M., Lewinsohn, David M.

“…Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, remains a global health concern. Both classically and non-classically…”
Get full text

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress by Gold, M C, Eid, T, Smyk-Pearson, S, Eberling, Y, Swarbrick, G M, Langley, S M, Streeter, P R, Lewinsohn, D A, Lewinsohn, D M

“…Human mucosal-associated invariant T (MAIT) cells express the semi-invariant T-cell receptor (TCR) Vα7.2 and are restricted by the major histocompatibility…”
Get full text

State-dependent evolutionary models reveal modes of solid tumour growth by Lewinsohn, Maya A., Bedford, Trevor, Müller, Nicola F., Feder, Alison F.

“…Spatial properties of tumour growth have profound implications for cancer progression, therapeutic resistance and metastasis. Yet, how spatial position governs…”
Get full text

Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting by Balfour, Avuyonke, Schutz, Charlotte, Goliath, Rene, Wilkinson, Katalin A, Sayed, Sumaya, Sossen, Bianca, Kanyik, Jean-Paul, Ward, Amy, Ndzhukule, Rhandzu, Gela, Anele, Lewinsohn, David M, Lewinsohn, Deborah A, Meintjes, Graeme, Shey, Muki

“…MAIT cells are non-classically restricted T lymphocytes that recognize and rapidly respond to microbial metabolites or cytokines and have the capacity to kill…”
Get full text

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans by Swarbrick, Gwendolyn M, Gela, Anele, Cansler, Meghan E, Null, Megan D, Duncan, Rowan B, Nemes, Elisa, Shey, Muki, Nsereko, Mary, Mayanja-Kizza, Harriet, Kiguli, Sarah, Koh, Jeffrey, Hanekom, Willem A, Hatherill, Mark, Lancioni, Christina, Lewinsohn, David M, Scriba, Thomas J, Lewinsohn, Deborah A

“…MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most…”
Get full text

Modulation of riboflavin biosynthesis and utilization in mycobacteria by Chengalroyen, Melissa D, Mehaffy, Carolina, Lucas, Megan, Bauer, Niel, Raphela, Mabule L, Oketade, Nurudeen, Warner, Digby F, Lewinsohn, Deborah A, Lewinsohn, David M, Dobos, Karen M, Mizrahi, Valerie

“…Riboflavin (vitamin B ) is the precursor of the flavin coenzymes, FAD and FMN, which play a central role in cellular redox metabolism. While humans must obtain…”
Get full text

Childhood tuberculosis in northern Viet Nam: a review of 103 cases by Blount, Robert J, Tran, Bao, Jarlsberg, Leah G, Phan, Ha, Thanh Hoang, Van, Nguyen, Nhung Viet, Lewinsohn, Deborah A, Nahid, Payam

“…Childhood tuberculosis causes significant morbidity and mortality in Southeast Asia, yet little is known about the epidemiology and clinical characteristics of…”
Get full text

Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library by Lewinsohn, David M, Swarbrick, Gwendolyn M, Cansler, Meghan E, Null, Megan D, Rajaraman, Veena, Frieder, Marisa M, Sherman, David R, McWeeney, Shannon, Lewinsohn, Deborah A

“…Identification of CD8(+) T cell antigens/epitopes expressed by human pathogens with large genomes is especially challenging, yet necessary for vaccine…”
Get full text

The effects of bed height and time on the quality of chest compressions delivered during cardiopulmonary resuscitation: a randomised crossover simulation study by Lewinsohn, A, Sherren, P B, Wijayatilake, D S

“…The 2010 International Liaison Committee on Resuscitation gave a detailed update on best practice for cardiopulmonary resuscitation (CPR) with a discussion on…”
Get more information

Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment by Nyendak, Melissa R, Park, Byung, Null, Megan D, Baseke, Joy, Swarbrick, Gwendolyn, Mayanja-Kizza, Harriet, Nsereko, Mary, Johnson, Denise F, Gitta, Phineas, Okwera, Alphonse, Goldberg, Stefan, Bozeman, Lorna, Johnson, John L, Boom, W Henry, Lewinsohn, Deborah A, Lewinsohn, David M

“…Biomarkers associated with response to therapy in tuberculosis could have broad clinical utility. We postulated that the frequency of Mycobacterium…”
Get full text

The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle by Grotzke, Jeff E, Harriff, Melanie J, Siler, Anne C, Nolt, Dawn, Delepine, Jacob, Lewinsohn, Deborah A, Lewinsohn, David M

“…Mycobacterium tuberculosis (Mtb) resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and…”
Get full text

Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B by Lewinsohn, Deborah A, Winata, Ervina, Swarbrick, Gwendolyn M, Tanner, Katie E, Cook, Matthew S, Null, Megan D, Cansler, Meghan E, Sette, Alessandro, Sidney, John, Lewinsohn, David M

“…CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria…”
Get full text

Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis by Morrow, Erin, Liu, Qijia, Kiguli, Sarah, Swarbrick, Gwendolyn, Nsereko, Mary, Null, Megan D, Cansler, Meghan, Mayanja-Kizza, Harriet, Boom, W Henry, Chheng, Phalkun, Nyendak, Melissa R, Lewinsohn, David M, Lewinsohn, Deborah A, Lancioni, Christina L

“…Tuberculosis (TB), caused by (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure,…”
Get full text