Search Results - "Lewin, Sharon R."

HIV infection: epidemiology, pathogenesis, treatment, and prevention by Maartens, Gary, Prof, Celum, Connie, Prof, Lewin, Sharon R, Prof

“…Summary HIV prevalence is increasing worldwide because people on antiretroviral therapy are living longer, although new infections decreased from 3·3 million…”
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The end of AIDS: HIV infection as a chronic disease by Deeks, Steven G, Prof, Lewin, Sharon R, Prof, Havlir, Diane V, Prof

“…Summary The success of antiretroviral therapy has led some people to now ask whether the end of AIDS is possible. For patients who are motivated to take…”
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Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 by Thevarajan, Irani, Nguyen, Thi H. O., Koutsakos, Marios, Druce, Julian, Caly, Leon, van de Sandt, Carolien E., Jia, Xiaoxiao, Nicholson, Suellen, Catton, Mike, Cowie, Benjamin, Tong, Steven Y. C., Lewin, Sharon R., Kedzierska, Katherine

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CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART by Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B, Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M, Bacchetti, Peter, Deeks, Steven G, Lewin, Sharon R, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these…”
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Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society—Lancet Commission by Bekker, Linda-Gail, Alleyne, George, Baral, Stefan, Cepeda, Javier, Daskalakis, Demetre, Dowdy, David, Dybul, Mark, Eholie, Serge, Esom, Kene, Garnett, Geoff, Grimsrud, Anna, Hakim, James, Havlir, Diane, Isbell, Michael T, Johnson, Leigh, Kamarulzaman, Adeeba, Kasaie, Parastu, Kazatchkine, Michel, Kilonzo, Nduku, Klag, Michael, Klein, Marina, Lewin, Sharon R, Luo, Chewe, Makofane, Keletso, Martin, Natasha K, Mayer, Kenneth, Millett, Gregorio, Ntusi, Ntobeko, Pace, Loyce, Pike, Carey, Piot, Peter, Pozniak, Anton, Quinn, Thomas C, Rockstroh, Jurgen, Ratevosian, Jirair, Ryan, Owen, Sippel, Serra, Spire, Bruno, Soucat, Agnes, Starrs, Ann, Strathdee, Steffanie A, Thomson, Nicholas, Vella, Stefano, Schechter, Mauro, Vickerman, Peter, Weir, Brian, Beyrer, Chris

“…Recent trends in the HIV response are especially concerning. Although the number of new HIV infections and AIDS-related deaths have markedly decreased since…”
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PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals by Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in latently infected CD4 + T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed…”
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HIV cure and eradication: how will we get from the laboratory to effective clinical trials? by LEWIN, Sharon R, ROUZIOUX, Christine

“…Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity; however, HIV can still not be cured. Achieving…”
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Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection by Sandler, Netanya G., Wand, Handan, Roque, Annelys, Law, Matthew, Nason, Martha C., Nixon, Daniel E., Pedersen, Court, Ruxrungtham, Kiat, Lewin, Sharon R., Emery, Sean, Neaton, James D., Brenchley, Jason M., Deeks, Steven G., Sereti, Irini, Douek, Daniel C.

“…Background. Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to…”
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Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial by Rasmussen, Thomas A, Dr, Tolstrup, Martin, PhD, Brinkmann, Christel R, PhD, Olesen, Rikke, PhD, Erikstrup, Christian, MD, Solomon, Ajantha, Winckelmann, Anni, Palmer, Sarah, PhD, Dinarello, Charles, Prof, Buzon, Maria, PhD, Lichterfeld, Mathias, MD, Lewin, Sharon R, Prof, Østergaard, Lars, Prof, Søgaard, Ole S, MD

“…Summary Background Activating the expression of latent virus is an approach that might form part of an HIV cure. We assessed the ability of the histone…”
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An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients by Spina, Celsa A, Anderson, Jenny, Archin, Nancie M, Bosque, Alberto, Chan, Jonathan, Famiglietti, Marylinda, Greene, Warner C, Kashuba, Angela, Lewin, Sharon R, Margolis, David M, Mau, Matthew, Ruelas, Debbie, Saleh, Suha, Shirakawa, Kotaro, Siliciano, Robert F, Singhania, Akul, Soto, Paula C, Terry, Valeri H, Verdin, Eric, Woelk, Christopher, Wooden, Stacey, Xing, Sifei, Planelles, Vicente

“…The possibility of HIV-1 eradication has been limited by the existence of latently infected cellular reservoirs. Studies to examine control of HIV latency and…”
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study by Elliott, Julian H, MBBS, McMahon, James H, MBBS, Chang, Christina C, MBBS, Lee, Sulggi A, MD, Hartogensis, Wendy, PhD, Bumpus, Namandje, PhD, Savic, Rada, PhD, Roney, Janine, MPH, Hoh, Rebecca, BA, Solomon, Ajantha, BSc, Piatak, Michael, PhD, Gorelick, Robert J, PhD, Lifson, Jeff, PhD, Bacchetti, Peter, Prof, Deeks, Steven G, Prof, Lewin, Sharon R, Prof

“…Summary Background In vitro, disulfiram activated HIV transcription in a primary T-cell model of HIV latency and in a pilot clinical study increased plasma HIV…”
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Combination Immune Checkpoint Blockade to Reverse HIV Latency by Van der Sluis, Renée M, Kumar, Nitasha A, Pascoe, Rachel D, Zerbato, Jennifer M, Evans, Vanessa A, Dantanarayana, Ashanti I, Anderson, Jenny L, Sékaly, Rafick P, Fromentin, Rémi, Chomont, Nicolas, Cameron, Paul U, Lewin, Sharon R

“…In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4 T cells expressing multiple…”
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Perceptions of HIV cure research among people living with HIV in Australia by Power, Jennifer, Westle, Andrew, Dowsett, Gary W, Lucke, Jayne, Tucker, Joseph D, Sugarman, Jeremy, Lewin, Sharon R, Hill, Sophie, Brown, Graham, Wallace, Jack, Richmond, Jacqui

“…Participation in HIV cure-related clinical trials that involve antiretroviral treatment (ART) interruption may pose substantial individual risks for people…”
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HDAC inhibitors in HIV by Wightman, Fiona, Ellenberg, Paula, Churchill, Melissa, Lewin, Sharon R

“…Combination antiretroviral therapy (cART) has led to a very substantial reduction in morbidity and mortality in HIV‐infected patients; however, cART alone is…”
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Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy by To, Eunice E., Vlahos, Ross, Luong, Raymond, Halls, Michelle L., Reading, Patrick C., King, Paul T., Chan, Christopher, Drummond, Grant R., Sobey, Christopher G., Broughton, Brad R. S., Starkey, Malcolm R., van der Sluis, Renee, Lewin, Sharon R., Bozinovski, Steven, O’Neill, Luke A. J., Quach, Tim, Porter, Christopher J. H., Brooks, Doug A., O’Leary, John J., Selemidis, Stavros

“…The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting…”
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Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells by Ke, Ruian, Lewin, Sharon R, Elliott, Julian H, Perelson, Alan S

“…Recent efforts to cure human immunodeficiency virus type-1 (HIV-1) infection have focused on developing latency reversing agents as a first step to eradicate…”
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The significance and expectations of HIV cure research among people living with HIV in Australia by Power, Jennifer, Dowsett, Gary W, Westle, Andrew, Tucker, Joseph D, Hill, Sophie, Sugarman, Jeremy, Lewin, Sharon R, Brown, Graham, Lucke, Jayne

“…Most people living with HIV (PLHIV) with reliable access to antiretroviral treatment (ART) have a life expectancy similar to uninfected populations. Despite…”
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Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage by Rajasuriar, Reena, Wright, Edwina, Lewin, Sharon R

“…PURPOSE OF REVIEWThe purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on…”
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Immune checkpoint blockade in HIV by Gubser, Celine, Chiu, Chris, Lewin, Sharon R., Rasmussen, Thomas A.

“…Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and…”
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