Search Results - "Lewin, S. A."

Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells by Luker, K E, Lewin, S A, Mihalko, L A, Schmidt, B T, Winkler, J S, Coggins, N L, Thomas, D G, Luker, G D

“…Chemokine CXCL12 and receptor CXCR4 control multiple steps in primary tumor growth and metastasis in breast cancer and more than 20 other human malignancies…”
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Lay health workers in primary and community health care by Lewin, S A, Dick, J, Pond, P, Zwarenstein, M, Aja, G, van Wyk, B, Bosch-Capblanch, X, Patrick, M

“…Lay health workers (LHWs) are widely used to provide care for a broad range of health issues. However, little is known about the effectiveness of LHW…”
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rAAV2 5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters by Beltran, W A, Boye, S L, Boye, S E, Chiodo, V A, Lewin, A S, Hauswirth, W W, Aguirre, G D

“…A prerequisite for using corrective gene therapy to treat humans with inherited retinal degenerative diseases that primarily affect rods is to develop viral…”
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Marijuana Use in Potential Liver Transplant Candidates by Ranney, D. N., Acker, W. B., Al‐Holou, S. N., Ehrlichman, L., Lee, D. S., Lewin, S. A., Nguyen, C., Peterson, S. F., Sell, K., Kubus, J., Reid, D., Englesbe, M. J.

“…Concern exists that liver transplant center substance abuse policies may have an inappropriate and disproportionate impact on marijuana users. Our hypothesis…”
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Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery by Gorbatyuk, M., Justilien, V., Liu, J., Hauswirth, W.W., Lewin, A.S.

“…The purpose of this study is to demonstrate that the expression of rhodopsin can be down regulated in vivo by AAV-delivered siRNA. This is the first step in an…”
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RNA knockdown as a potential therapeutic strategy in Parkinson's disease by Manfredsson, F P, Lewin, A S, Mandel, R J

“…Parkinson's disease is a prevalent progressive degenerative disorder of the elderly. There is a current need for novel therapeutic strategies because the…”
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Reduction in Preretinal Neovascularization by Ribozymes That Cleave the A2B Adenosine Receptor mRNA by Afzal, A, Shaw, L C, Caballero, S, Spoerri, P E, Lewin, A S, Zeng, D, Belardinelli, L, Grant, M B

“…ABSTRACT—Adenosine modulates a variety of cellular functions by interacting with specific cell surface G protein–coupled receptors (A1, A2A, A2B, and A3) and…”
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Noninvasive Imaging by Optical Coherence Tomography to Monitor Retinal Degeneration in the Mouse by Li, Qiuhong, Timmers, Adrian M, Hunter, Kirk, Gonzalez-Pola, Carlos, Lewin, Alfred S, Reitze, David H, Hauswirth, William W

“…Optical coherence tomography (OCT) is a high-resolution imaging technique that measures the intensity of backscattered light from biological microstructures in…”
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Interventions for providers to promote a patient-centred approach in clinical consultations by Lewin, S A, Skea, Z C, Entwistle, V, Zwarenstein, M, Dick, J

“…Communication problems in health care may arise as a result of health care providers focusing on diseases and their management, rather than people, their lives…”
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Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse cochlea by Aarnisalo, A.A., Pietola, L., Joensuu, J., Isosomppi, J., Aarnisalo, P., Dinculescu, A., Lewin, A.S., Flannery, J., Hauswirth, W.W., Sankila, E.-M., Jero, J.

“…Usher syndrome type 3 is caused by mutations in the USH3A gene, which encodes the protein clarin-1. Clarin-1 is a member of the tetraspanin superfamily (TM4SF)…”
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Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme by Gorbatyuk, M., Justilien, V., Liu, J., Hauswirth, W.W., Lewin, A.S.

“…To develop an allele independent ribozyme for the treatment of autosomal dominant retinitis pigmentosa (ADRP) associated with mutations in the rhodopsin ( RHO)…”
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Selective autophagy of peroxisomes in methylotrophic yeasts by Tuttle, D L, Lewin, A S, Dunn, Jr, W A

“…The methylotrophic yeasts Pichia pastoris and Hansenula polymorpha respond to a methanol substrate by synthesizing peroxisomal enzymes resulting in the…”
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Citrate synthase encoded by the CIT2 gene of Saccharomyces cerevisiae is peroxisomal by LEWIN, A. S, HINES, V, SMALL, G. M

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Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy by Liu, J, Saghizadeh, M, Tuli, S S, Kramerov, A A, Lewin, A S, Bloom, D C, Hauswirth, W W, Castro, M G, Schultz, G S, Ljubimov, A V

“…Diseased corneas are potential targets for viral-based gene therapy to normalize (stimulate or inhibit) the expression of specific proteins. The choice of…”
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Ribozyme gene therapy for autosomal dominant retinal disease by Hauswirth, W W, LaVail, M M, Flannery, J G, Lewin, A S

“…Gene delivery to cells of the retina, particularly to photoreceptor cells, has broad potential both for answering basic questions of retinal biology and for…”
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Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species by NGUYEN, M. H, CLANCY, C. J, YU, Y. C, LEWIN, A. S

“…The potential role of azithromycin in combination with amphotericin B against 25 clinical isolates of Aspergillus was assessed. The MIC of amphotericin B was 1…”
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Autocatalytic activities of intron 5 of the cob gene of yeast mitochondria by PARTONO, S, LEWIN, A. S

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Production and purification of recombinant adeno-associated virus by Hauswirth, W W, Lewin, A S, Zolotukhin, S, Muzyczka, N

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Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa by Lewin, Alfred S, Drenser, Kimberly A, Hauswirth, William W, Nishikawa, Shimpei, Yasumura, Douglas, Flannery, John G, LaVail, Matthew M

“…Ribozymes, catalytic RNA molecules that cleave a complementary mRNA sequence, have potential as therapeutics for dominantly inherited disease. Twelve percent…”
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Ribozyme gene therapy: applications for molecular medicine by Lewin, Alfred S, Hauswirth, William W

“…RNA enzymes – ribozymes – are being developed as treatments for a variety of diseases ranging from inborn metabolic disorders to viral infections and acquired…”
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