Search Results - "Lewicki, Sarah A"

Functionalized Congeners of 2H-Chromene P2Y6 Receptor Antagonists by Oliva, Paola, Pramanik, Asmita, Young-Hwan, Jung, Lewicki, Sarah A, Mwendwa, Jamie M, Park, Jong Hwan, Jacobson, Kenneth A

“…The P2Y6 receptor (P2Y6R), a Gq-coupled receptor, is a potential drug discovery target for various inflammatory and degenerative conditions. Antagonists have…”
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Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists by Jung, Young-Hwan, Shah, Qasim, Lewicki, Sarah A., Pramanik, Asmita, Gopinatth, Varun, Pelletier, Julie, Sévigny, Jean, Iqbal, Jamshed, Jacobson, Kenneth A.

“…P2Y6 receptor (P2Y6R) antagonists represent potential drugs for treating cancer, pain, neurodegeneration, asthma, diabetes, colitis and other disorders…”
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Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 H -naphtho[1,2- b ][1,4]diazepine-2,4(3 H )-diones as P2X4 Receptor Antagonists by Toti, Kiran S, Verma, Rajkumar, McGonnigle, Michael J, Gamiotea Turro, Daylin, Wen, Zhiwei, Lewicki, Sarah A, Liang, Bruce T, Jacobson, Kenneth A

“…We analyzed the P2X4 receptor structure-activity relationship of a known antagonist , a 1,5-dihydro-2 -naphtho[1,2- ][1,4]diazepine-2,4(3 )-dione. Following…”
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Machine learning-aided search for ligands of P2Y6 and other P2Y receptors by Puhl, Ana C., Lewicki, Sarah A., Gao, Zhan-Guo, Pramanik, Asmita, Makarov, Vadim, Ekins, Sean, Jacobson, Kenneth A.

“…The P2Y 6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative, and metabolic disorders, yet few…”
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Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates by Zhang, Hai-Jun, Ociepa, Michał, Nassir, Molhm, Zheng, Bin, Lewicki, Sarah A., Salmaso, Veronica, Baburi, Helay, Nagel, Jessica, Mirza, Salahuddin, Bueschbell, Beatriz, Al-Hroub, Haneen, Perzanowska, Olga, Lin, Ziqin, Schmidt, Michael A., Eastgate, Martin D., Jacobson, Kenneth A., Müller, Christa E., Kowalska, Joanna, Jemielity, Jacek, Baran, Phil S.

“…Nucleoside diphosphates and triphosphates impact nearly every aspect of biochemistry; however, the use of such compounds as tools or medicinal leads for…”
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Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y 14 Receptor Antagonists by Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A, Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C R, Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A, Whitehead, Gregory S, Liang, Bruce T, Breton, Sylvie, Salvemini, Daniela, Cook, Donald N, Jacobson, Kenneth A

“…P2Y receptor (P2Y R) is activated by extracellular UDP-glucose, a damage-associated molecular pattern that promotes inflammation in the kidney, lung, fat…”
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Alicyclic Ring Size Variation of 4‑Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists by Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A., Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C. R., Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A., Whitehead, Gregory S., Liang, Bruce T., Breton, Sylvie, Salvemini, Daniela, Cook, Donald N., Jacobson, Kenneth A.

“…P2Y14 receptor (P2Y14R) is activated by extracellular UDP-glucose, a damage-associated molecular pattern that promotes inflammation in the kidney, lung, fat…”
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Structure activity relationships of 5-HT2B and 5-HT2C serotonin receptor antagonists: N6, C2 and 5′-Modified (N)-methanocarba-adenosine derivatives by Tosh, Dilip K., Calkins, Maggie M., Ivancich, Marko S., Bock, Hailey A., Campbell, Ryan G., Lewicki, Sarah A., Chen, Eric, Gao, Zhan-Guo, McCorvy, John D., Jacobson, Kenneth A.

“…(N)-Methanocarba adenosine derivatives were structurally modified to target 5-HT2B serotonin receptors as antagonists, predominantly containing branched…”
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In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs by Xiao, Cuiying, Gavrilova, Oksana, Liu, Naili, Lewicki, Sarah A., Reitman, Marc L., Jacobson, Kenneth A.

“…Some non-adenosinergic drugs are reported to also act through adenosine receptors (ARs). We used mouse hypothermia, which can be induced by agonism at any of…”
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Chimeras Derived from a P2Y 14 Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation by Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A, Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C R, Breton, Sylvie, Chen, Zhoumou, Whitehead, Gregory S, Salvemini, Daniela, Cook, Donald N, Jacobson, Kenneth A

“…Tethered glycoconjugates of a naphthalene- and piperidine-containing antagonist of the P2Y receptor (PPTN) were synthesized, and their nM receptor binding…”
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Chimeras Derived from a P2Y14 Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation by Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A., Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C. R., Breton, Sylvie, Chen, Zhoumou, Whitehead, Gregory S., Salvemini, Daniela, Cook, Donald N., Jacobson, Kenneth A.

“…Tethered glycoconjugates of a naphthalene- and piperidine-containing antagonist of the P2Y14 receptor (PPTN) were synthesized, and their nM receptor binding…”
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2‑Substituted (N)-Methanocarba A3 Adenosine Receptor Agonists: In Silico, In Vitro, and In Vivo Characterization by Tosh, Dilip K., Pavan, Matteo, Cronin, Chunxia, Pottie, Eline, Wan, Tina C., Chen, Eric, Lewicki, Sarah A., Campbell, Ryan G., Gao, Zhan-Guo, Auchampach, John A., Stove, Christophe P., Liang, Bruce T., Jacobson, Kenneth A.

“…2-Arylethynyl (N)-methanocarba adenosine 5′-methylamides are selective A3 adenosine receptor (AR) agonists containing a preestablished receptor-preferred…”
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2-Substituted (N)-Methanocarba A 3 Adenosine Receptor Agonists: In Silico, In Vitro, and In Vivo Characterization by Tosh, Dilip K, Pavan, Matteo, Cronin, Chunxia, Pottie, Eline, Wan, Tina C, Chen, Eric, Lewicki, Sarah A, Campbell, Ryan G, Gao, Zhan-Guo, Auchampach, John A, Stove, Christophe P, Liang, Bruce T, Jacobson, Kenneth A

“…2-Arylethynyl (N)-methanocarba adenosine 5'-methylamides are selective A adenosine receptor (AR) agonists containing a preestablished receptor-preferred…”
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Structure–Activity Relationship and Neuroprotective Activity of 1,5-Dihydro‑2H‑naphtho[1,2‑b][1,4]diazepine-2,4(3H)‑diones as P2X4 Receptor Antagonists by Toti, Kiran S., Verma, Rajkumar, McGonnigle, Michael J., Gamiotea Turro, Daylin, Wen, Zhiwei, Lewicki, Sarah A., Liang, Bruce T., Jacobson, Kenneth A.

“…We analyzed the P2X4 receptor structure–activity relationship of a known antagonist 5, a 1,5-dihydro-2H-naphtho­[1,2-b]­[1,4]­diazepine-2,4­(3H)-dione…”
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Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho1,2-b1,4diazepine-2,4(3H)-diones as P2X4 Receptor Antagonists by Toti, Kiran S, Verma, Rajkumar, McGonnigle, Michael J, Gamiotea Turro, Daylin, Wen, Zhiwei, Lewicki, Sarah A, Liang, Bruce T, Jacobson, Kenneth A

“…We analyzed the P2X4 receptor structure-activity relationship of a known antagonist 5, a 1,5-dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-dione. Following…”
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Potent and Selective Human 5-HT 2B Serotonin Receptor Antagonists: 4′-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity by Tosh, Dilip K., Pavan, Matteo, Clark, Allison A., Lammers, Josie, Villano, Serafina, Marri, Silvia, Sgambellone, Silvia, Choi, Suebin, Lee, Jihyun, Ivancich, Marko S., Bock, Hailey A., Campbell, Ryan G., Lewicki, Sarah A., Levitan, Ian M., Chen, Eric, Liu, Naili, Demby, Tamar, Gavrilova, Oksana, Gao, Zhan-Guo, Lucarini, Laura, McCorvy, John D., Jacobson, Kenneth A.

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Functionalized Congeners of 2H-Chromene P2Y[sub.6] Receptor Antagonists by Oliva, Paola, Pramanik, Asmita, Jung, Young-Hwan, Lewicki, Sarah A, Mwendwa, Jamie M, Park, Jong Hwan, Jacobson, Kenneth A

“…The P2Y[sub.6] receptor (P2Y[sub.6]R), a G[sub.q]-coupled receptor, is a potential drug discovery target for various inflammatory and degenerative conditions…”
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Functionalized Congeners of 2 H -Chromene P2Y 6 Receptor Antagonists by Oliva, Paola, Pramanik, Asmita, Jung, Young-Hwan, Lewicki, Sarah A, Mwendwa, Jamie M, Park, Jong Hwan, Jacobson, Kenneth A

“…The P2Y receptor (P2Y R), a G -coupled receptor, is a potential drug discovery target for various inflammatory and degenerative conditions. Antagonists have…”
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Machine learning-aided search for ligands of P2Y 6 and other P2Y receptors by Puhl, Ana C, Lewicki, Sarah A, Gao, Zhan-Guo, Pramanik, Asmita, Makarov, Vadim, Ekins, Sean, Jacobson, Kenneth A

“…The P2Y receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative, and metabolic disorders, yet few…”
Get full text

Structure activity relationships of 5-HT 2B and 5-HT 2C serotonin receptor antagonists: N 6 , C2 and 5'-Modified (N)-methanocarba-adenosine derivatives by Tosh, Dilip K, Calkins, Maggie M, Ivancich, Marko S, Bock, Hailey A, Campbell, Ryan G, Lewicki, Sarah A, Chen, Eric, Gao, Zhan-Guo, McCorvy, John D, Jacobson, Kenneth A

“…(N)-Methanocarba adenosine derivatives were structurally modified to target 5-HT serotonin receptors as antagonists, predominantly containing branched N -alkyl…”
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