Search Results - "Leweke, F. Markus"
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Cannabis use and psychosis: a review of reviews
Published in European archives of psychiatry and clinical neuroscience (01-06-2020)“…We conducted a systematic review of meta-analyses and systematic reviews to evaluate the impact of cannabis use on the onset and course of psychoses. Following…”
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Right care, first time: a highly personalised and measurement‐based care model to manage youth mental health
Published in Medical journal of Australia (01-11-2019)“…Summary Mood and psychotic syndromes most often emerge during adolescence and young adulthood, a period characterised by major physical and social change…”
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Anandamide dysfunction in prodromal and established psychosis
Published in Current pharmaceutical design (01-11-2012)“…There is epidemiological evidence that frequent cannabis use in general and during puberty in particular increases the risk to suffer psychosis and psychotic…”
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Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages
Published in eLife (27-09-2018)“…We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical…”
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Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia
Published in Schizophrenia research (01-08-2013)“…Abstract The origin of inflammation in psychiatric disorders is not well understood. The translocation of commensal microbiota across the gastrointestinal…”
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Obituary for Professor Hinderk Meiners Emrich, MD PhD
Published in European archives of psychiatry and clinical neuroscience (01-12-2018)“…On 16 September 2018 Professor Hinderk Meiners Emrich, MD PhD, Emeritus Director of the Department of Psychiatry, Social Psychiatry and Psychotherapy of…”
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Cannabidiol and Amisulpride Improve Cognition in Acute Schizophrenia in an Explorative, Double-Blind, Active-Controlled, Randomized Clinical Trial
Published in Frontiers in pharmacology (29-04-2021)“…Cannabidiol (CBD), a principal phytocannabinoid constituent, has demonstrated antipsychotic properties in recent clinical trials. While it has also been…”
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Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia: Implications for Pharmacological Intervention
Published in CNS drugs (01-07-2018)“…The term schizophrenia describes a group of multifaceted psychiatric conditions causing significant impairment of the quality of life of affected patients…”
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Cannabidiol enhances cerebral glucose utilization and ameliorates psychopathology and cognition: A case report in a clinically high-risk mental state
Published in Frontiers in psychiatry (03-03-2023)“…Adolescent individuals often present with subtle, sub-threshold psychiatric syndromes that fluctuate or persist for years. These symptoms have been classified…”
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Current State of Fluid Lipid Biomarkers for Personalized Diagnostics and Therapeutics in Schizophrenia Spectrum Disorders and Related Psychoses: A Narrative Review
Published in Frontiers in psychiatry (27-05-2022)“…Schizophrenia spectrum disorders (SSD) are traditionally diagnosed and categorized through clinical assessment, owing to their complex heterogeneity and an…”
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Evidence for dysregulated high-frequency oscillations during sensory processing in medication-naïve, first episode schizophrenia
Published in Schizophrenia research (01-11-2013)“…Abstract Introduction High-frequency oscillations are important for sensory processing and dysfunctions in the amplitude and synchrony of beta- and gamma-band…”
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Different pharmaceutical preparations of Δ9‐tetrahydrocannabinol differentially affect its behavioral effects in rats
Published in Addiction biology (01-05-2020)“…Based on the contribution of the endocannabinoid system to the pathophysiology of schizophrenia, the primary pro‐psychotic ingredient of Cannabis sativa,…”
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ReTimeML: a retention time predictor that supports the LC–MS/MS analysis of sphingolipids
Published in Scientific reports (22-02-2024)“…The analysis of ceramide (Cer) and sphingomyelin (SM) lipid species using liquid chromatography–tandem mass spectrometry (LC–MS/MS) continues to present…”
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Reduced superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with early psychosis in association with clinical features
Published in Schizophrenia research (01-05-2017)“…Abstract Oxidative stress is implicated in the underlying pathophysiology of psychosis from studies of animal models and of tissues obtained from patients…”
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Distinct molecular phenotypes in male and female schizophrenia patients
Published in PloS one (11-11-2013)“…In schizophrenia, sex specific dimorphisms related to age of onset, course of illness and response to antipsychotic treatment may be mirrored by sex-related…”
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Neural Autoantibodies in Cerebrospinal Fluid and Serum in Clinical High Risk for Psychosis, First-Episode Psychosis, and Healthy Volunteers
Published in Frontiers in psychiatry (26-03-2021)“…The pathophysiological role of neural autoantibodies in acute psychotic disorders is receiving increased attention. However, there is still an ongoing debate,…”
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Neural correlates of binocular depth inversion illusion in antipsychotic-naïve first-episode schizophrenia patients
Published in European archives of psychiatry and clinical neuroscience (01-12-2019)“…Objectives Binocular depth inversion illusion (BDII), a visual, ‘top–down’-driven information process, is impaired in schizophrenia and particularly in its…”
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The Functional Networks of Prepulse Inhibition: Neuronal Connectivity Analysis Based on FDG-PET in Awake and Unrestrained Rats
Published in Frontiers in behavioral neuroscience (21-07-2016)“…Prepulse inhibition (PPI) is a neuropsychological process during which a weak sensory stimulus ("prepulse") attenuates the motor response ("startle reaction")…”
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Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis
Published in British journal of psychiatry (01-04-2009)“…Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its…”
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Cerebrospinal Anandamide Levels are Elevated in Acute Schizophrenia and are Inversely Correlated with Psychotic Symptoms
Published in Neuropsychopharmacology (01-11-2004)“…The endocannabinoids are a family of bioactive lipids that activate CB1 cannabinoid receptors in the brain and exert intense emotional and cognitive effects…”
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