Search Results - "Lewalle, Alexandre"

Editorial: Biophysics of muscle contraction by Alexandre Lewalle

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Analysis of turnover dynamics of the submembranous actin cortex by Fritzsche, Marco, Lewalle, Alexandre, Duke, Tom, Kruse, Karsten, Charras, Guillaume

“…The cell cortex is a thin network of actin, myosin motors, and associated proteins that underlies the plasma membrane in most eukaryotic cells. It enables…”
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Mechanisms of leading edge protrusion in interstitial migration by Wilson, Kerry, Lewalle, Alexandre, Fritzsche, Marco, Thorogate, Richard, Duke, Tom, Charras, Guillaume

“…While the molecular and biophysical mechanisms underlying cell protrusion on two-dimensional substrates are well understood, our knowledge of the actin…”
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Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways by Rodero, Cristobal, Baptiste, Tiffany M G, Barrows, Rosie K, Lewalle, Alexandre, Niederer, Steven A, Strocchi, Marina

“…Cardiac mechanics models are developed to represent a high level of detail, including refined anatomies, accurate cell mechanics models, and platforms to link…”
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Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts by Lewalle, Alexandre, Land, Sander, Carruth, Eric, Frank, Lawrence R, Lamata, Pablo, Omens, Jeffrey H, McCulloch, Andrew D, Niederer, Steven A, Smith, Nicolas P

“…The cardiac system compensates for variations in physiological and pathophysiological conditions through a dynamic remodeling at the organ, tissue, and…”
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A phenomenological density-scaling approach to lamellipodial actin dynamics by Lewalle, Alexandre, Fritzsche, Marco, Wilson, Kerry, Thorogate, Richard, Duke, Tom, Charras, Guillaume

“…The integration of protein function studied in vitro in a dynamic system like the cell lamellipodium remains a significant challenge. One reason is the…”
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Reconciling the Working Strokes of a Single Head of Skeletal Muscle Myosin Estimated from Laser-Trap Experiments and Crystal Structures by Sleep, John, Lewalle, Alexandre, Smith, David

“…Myosin generates force by a rotation of its lever arm. Crystal structures of myosin II indicate an unloaded working stroke of 10-12 nm, a range confirmed by…”
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Modeling mechanisms of the thick-filament off-state dynamics in cardiac muscle by Lewalle, Alexandre, Milburn, Gregory, Campbell, Kenneth S., Niederer, Steven A.

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Development of a Patient‐Based Computational Modeling Framework for Analyzing the Mechanisms of Doxorubicin Cardiotoxicity by Lewalle, Alexandre, Land, Sander, Niederer, Steven

“…Abstract only Doxorubicin, a potent anticancer drug, has well known dose‐dependent cardiotoxic side effects. In particular, doxorubicin exposure disrupts…”
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Quantifying Contributions of Cellular Mechanical Myocardial Properties on Left Ventricular Contractile Function in Aortic Banded Rats by Longobardi, Stefano, Lewalle, Alexandre, Musante, Cynthia J., Sher, Anna, Niederer, Steven A.

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Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes by Tazmini, Kiarash, Frisk, Michael, Lewalle, Alexandre, Laasmaa, Martin, Morotti, Stefano, Lipsett, David B, Manfra, Ornella, Skogestad, Jonas, Aronsen, Jan M, Sejersted, Ole M, Sjaastad, Ivar, Edwards, Andrew G, Grandi, Eleonora, Niederer, Steven A, Øie, Erik, Louch, William E

“…Hypokalemia occurs in up to 20% of hospitalized patients and is associated with increased incidence of ventricular and atrial fibrillation. It is unclear…”
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Single-Molecule Measurement of the Stiffness of the Rigor Myosin Head by Lewalle, Alexandre, Steffen, Walter, Stevenson, Olivia, Ouyang, Zhenqian, Sleep, John

“…The force-extension curve of single myosin subfragment-1 molecules, interacting in the rigor state with an actin filament, has been investigated at low [ATP]…”
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Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure by Lewalle, Alexandre, Land, Sander, Merken, Jort J., Raafs, Anne, Sepúlveda, Pilar, Heymans, Stéphane, Kleinjans, Jos, Niederer, Steven A.

“…Late-onset heart failure (HF) is a known side effect of doxorubicin chemotherapy. Typically, patients are diagnosed when already at an irreversible stage of…”
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Species-Specific Comparison of the Cardiac Sodium/Potassium Pump Based on a Minimal Biophysical Model by Lewalle, Alexandre, Niederer, Steven, Smith, Nic

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Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats by Longobardi, S, Lewalle, A, Coveney, S, Sjaastad, I, Espe, E K S, Louch, W E, Musante, C J, Sher, A, Niederer, S A

“…Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical cardiac models offer a systematic approach for studying these…”
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Species‐dependent adaptation of the cardiac Na+/K+ pump kinetics to the intracellular Na+ concentration by Lewalle, Alexandre, Niederer, Steven A., Smith, Nicolas P.

“…Key Points The sodium/potassium pump is a membrane protein that maintains the Na+ and K+ concentration gradients across the plasma membrane and is therefore a…”
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Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes by Tazmini, Kiarash, Frisk, Michael, Laasmaa, Martin, Lewalle, Alexandre, Morotti, Stefano, Lipsett, David B., Manfra, Ornella, Skogested, Jonas, Magnus Aronsen, Jan, Sjaastad, Ivar, Edwards, Andrew G., Grandi, Eleonora, Niederer, Steven A., Øie, Erik, Louch, William E.

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Delocalisation in conjugated triazene chromophores: Insights from theory by Preat, Julien, Michaux, Catherine, Lewalle, Alexandre, Perpète, Eric A., Jacquemin, Denis

“…The structures and electronic spectra of conjugated triazenes are investigated with TD-DFT. The structures and electronic spectra of four conjugated triazenes…”
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A physicist in a foreign land by Lewalle, Alexandre

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The Smallest Tweezers in the World by Lewalle, Alexandre

“…A pair of fine tweezers and a steady hand may well be enough to pick up a grain of sand, but what would you use to hold something hundreds of times smaller…”
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