Search Results - "Levy, Nina S"

Molecular Insights into IQSEC2 Disease by Levy, Nina S, Borisov, Veronika, Lache, Orit, Levy, Andrew P

“…Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of…”
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Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection by Vardi, Moshe, Levy, Nina S., Levy, Andrew P.

“…Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against…”
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Daily Brief Heat Therapy Reduces Seizures in A350V IQSEC2 Mice and Is Associated with Correction of AMPA Receptor-Mediated Synaptic Dysfunction by Jada, Reem, Borisov, Veronika, Laury, Eliezer, Halpert, Shmuel, Levy, Nina S, Wagner, Shlomo, Netser, Shai, Walikonis, Randall, Carmi, Ido, Berlin, Shai, Levy, Andrew P

“…Purposeful induction of fever for healing, including the treatment of epilepsy, was used over 2000 years ago by Hippocrates. More recently, fever has been…”
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IQSEC2-Associated Intellectual Disability and Autism by Levy, Nina S, Umanah, George K E, Rogers, Eli J, Jada, Reem, Lache, Orit, Levy, Andrew P

“…Mutations in cause intellectual disability (ID), which is often accompanied by seizures and autism. A number of studies have shown that IQSEC2 is an abundant…”
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Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior by Lichtman, Daniela, Bergmann, Eyal, Kavushansky, Alexandra, Cohen, Nadav, Levy, Nina S., Levy, Andrew P., Kahn, Itamar

“…IQSEC2 is an X-linked gene that is associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. IQSEC2 is a postsynaptic density…”
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Conformational analysis of the IQSEC2 protein by statistical thermodynamics by Shokhen, Michael, Albeck, Amnon, Borisov, Veronika, Israel, Yonat, Levy, Nina S., Levy, Andrew P.

“…Mutations in the IQSEC2 gene result in severe intellectual disability, epilepsy and autism. The primary function of IQSEC2 is to serve as a guanine exchange…”
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Housing of A350V IQSEC2 pups at 37 °C ambient temperature prevents seizures and permits the development of social vocalizations in adulthood by Jada, Reem, Zag, Liron, Borisov, Veronika, Levy, Nina S., Netser, Shai, Jabarin, Renad, Wagner, Shlomo, Schragenheim-Rozales, Kinneret, Shalgi, Reut, Levy, Andrew P.

“…Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human…”
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An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors by Rogers, Eli J, Jada, Reem, Schragenheim-Rozales, Kinneret, Sah, Megha, Cortes, Marisol, Florence, Matthew, Levy, Nina S, Moss, Rachel, Walikonis, Randall S, Palty, Raz, Shalgi, Reut, Lichtman, Daniela, Kavushansky, Alexandra, Gerges, Nashaat Z, Kahn, Itamar, Umanah, George K E, Levy, Andrew P

“…We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular…”
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Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin by Guetta, Julia, Strauss, Merav, Levy, Nina S, Fahoum, Lana, Levy, Andrew P

“…Abstract The haptoglobin genotype has been demonstrated to be an independent risk factor for CVD in multiple epidemiological studies. The primary function of…”
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Haptoglobin Genotype Is a Determinant of Iron, Lipid Peroxidation, and Macrophage Accumulation in the Atherosclerotic Plaque by Levy, Andrew P, Levy, Joanne E, Kalet-Litman, Shiri, Miller-Lotan, Rachel, Levy, Nina S, Asaf, Roy, Guetta, Julia, Yang, Chingwen, Purushothaman, K Raman, Fuster, Valentin, Moreno, Pedro R

“…OBJECTIVE—Intraplaque hemorrhage increases the risk of plaque rupture and thrombosis. The release of hemoglobin (Hb) from extravasated erythrocytes at the site…”
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Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi by Levy, Andrew P, Levy, Nina S, Heyman, Eli, Schertz, Mitchell, Genizi, Jacob

“…A child with a A350V IQSEC2 missense mutation resulting in drug‐resistant epilepsy stops having seizures when he has a fever. We demonstrate that raising the…”
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Haptoglobin Genotype Is a Determinant of Hemoglobin Adducts and Vitamin E Content in HDL by Costacou, Tina, Ward, John, Levy, Nina S., Goldenstein, Hagit, Levy, Andrew P.

“…Haptoglobin (Hp) is an abundant hemoglobin- (Hb-) binding serum protein and a constituent of the HDL proteome. In man, there exists a common polymorphism at…”
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Genetically Determined Heterogeneity in Hemoglobin Scavenging and Susceptibility to Diabetic Cardiovascular Disease by Asleh, Rabea, Marsh, Stuart, Shilkrut, Mark, Binah, Ofer, Guetta, Julia, Lejbkowicz, Flavio, Enav, Ben, Shehadeh, Naim, Kanter, Yoram, Lache, Orit, Cohen, Osher, Levy, Nina S, Levy, Andrew P

“…ABSTRACT—A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage…”
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Structure-function analysis of the antioxidant properties of haptoglobin by Melamed-Frank, Meira, Lache, Orit, Enav, Benjamin I., Szafranek, Tal, Levy, Nina S., Ricklis, Rebecca M., Levy, Andrew P.

“…Haptoglobin serves as an antioxidant by virtue of its ability to prevent hemoglobin-driven oxidative tissue damage. It was recently demonstrated that an…”
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Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction by SULEIMAN, Mahmoud, ARONSON, Doron, HAMMERMAN, Haim, LOTAN, Rachel, LEVY, Nina S, LEVY, Andrew P, ASLEH, Rabea, KAPELIOVICH, Michael R, ROGUIN, Ariel, MEISEL, Simcha R, SHOCHAT, Michael, SULIEMAN, Abeer, REISNER, Shimon A, MARKIEWICZ, Walter

“…Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction Mahmoud Suleiman 1 , Doron…”
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Haptoglobin Genotype as a Determinant of Benefit or Harm From Niacin for Participants With Diabetes by Asleh, Rabea, MD, PhD, Levy, Nina S., PhD, Doros, Gheorge, PhD, Costacou, Tina, PhD, Robinson, Jennifer G., MD, MPH, Blum, Shany, MD, PhD, Goldenstein, Hagit, MSc, Boden, William E., MD, Simmons, Debra L., MD, MS, Lacy, Megan A., MS, Grunberger, George, MD, Anderson, Todd J., MD, Levy, Andrew P., MD, PhD

“…[...]one would predict that raising HDL levels in patients with Hp 2-2 DM may not have a favorable effect on HDL function. In a subset of AIM-HIGH participants…”
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Haptoglobin Genotype Is a Major Determinant of the Amount of Iron in the Human Atherosclerotic Plaque by Moreno, Pedro R., MD, FACC, Purushothaman, K. Raman, MD, Purushothaman, Meera, PhD, Muntner, Paul, PhD, Levy, Nina S., PhD, Fuster, Valentin, MD, PhD, FACC, Fallon, John T., MD, PhD, Lento, Patrick A., MD, Winterstern, Aaron, BS, Levy, Andrew P., MD, PhD, FACC

“…Haptoglobin Genotype Is a Major Determinant of the Amount of Iron in the Human Atherosclerotic Plaque Pedro R. Moreno, K. Raman Purushothaman, Meera…”
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Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice by Blum, Shany, MD, MSc, Asaf, Roy, Guetta, Julia, PhD, Miller-Lotan, Rachel, PhD, Asleh, Rabea, MSc, Kremer, Ran, MD, Levy, Nina S., PhD, Berger, Franklin G., MD, PhD, Aronson, Doron, MD, Fu, Xiaoming, PhD, Zhang, Renliang, PhD, Hazen, Stanley L., MD, PhD, Levy, Andrew P., MD, PhD, FACC

“…Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice Shany Blum, Roy Asaf, Julia Guetta, Rachel Miller-Lotan, Rabea Asleh, Ran Kremer, Nina…”
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IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission by Brant, Boris, Stern, Tchelet, Shekhidem, Huda Adwan, Mizrahi, Liron, Rosh, Idan, Stern, Yam, Ofer, Polina, Asleh, Ayat, Umanah, George K. Essien, Jada, Reem, Levy, Nina S., Levy, Andrew P., Stern, Shani

“…Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual disability (ID)…”
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Molecular modeling of ARF6 dysregulation caused by mutations in IQSEC2 by Shokhen, Michael, Walikonis, Randall, Uversky, Vladimir N., Allbeck, Amnon, Zezelic, Camryn, Feldman, Danielle, Levy, Nina S., Levy, Andrew P.

“…IQSEC2 gene mutations are associated with epilepsy, autism, and intellectual disability. The primary function IQSEC2, mediated via its Sec 7 domain, is to act…”
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