Search Results - "Levy, Laura M"

Synthesis of Biaryls via Catalytic Decarboxylative Coupling by Goossen, Lukas J, Deng, Guojun, Levy, Laura M

“…We present a safe and convenient cross-coupling strategy for the large-scale synthesis of biaryls, commercially important structures often found in…”
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Cellular model system to dissect the isoform-selectivity of Akt inhibitors by Quambusch, Lena, Depta, Laura, Landel, Ina, Lubeck, Melissa, Kirschner, Tonia, Nabert, Jonas, Uhlenbrock, Niklas, Weisner, Jörn, Kostka, Michael, Levy, Laura M., Schultz-Fademrecht, Carsten, Glanemann, Franziska, Althoff, Kristina, Müller, Matthias P., Siveke, Jens T., Rauh, Daniel

“…The protein kinase Akt plays a pivotal role in cellular processes. However, its isoforms’ distinct functions have not been resolved to date, mainly due to the…”
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Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering by Wolter, Madita, Valenti, Dario, Cossar, Peter J., Levy, Laura M., Hristeva, Stanimira, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian

“…Small‐molecule stabilization of protein–protein interactions (PPIs) is a promising concept in drug discovery, however the question how to identify or design…”
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Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3‑3 Hub Protein Interactions by Cossar, Peter J, Wolter, Madita, van Dijck, Lars, Valenti, Dario, Levy, Laura M, Ottmann, Christian, Brunsveld, Luc

“…The stabilization of protein complexes has emerged as a promising modality, expanding the number of entry points for novel therapeutic intervention. Targeting…”
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An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3‑3 Interaction with NF-κBUtilizing a Reversible Covalent Tethering Approach by Wolter, Madita, Valenti, Dario, Cossar, Peter J, Hristeva, Stanimira, Levy, Laura M, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian

“…Protein–protein modulation has emerged as a proven approach to drug discovery. While significant progress has been gained in developing protein–protein…”
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Biaryl Synthesis via Pd-Catalyzed Decarboxylative Coupling of Aromatic Carboxylates with Aryl Halides by Goossen, Lukas J, Rodríguez, Nuria, Melzer, Bettina, Linder, Christophe, Deng, Guojun, Levy, Laura M

“…A new strategy for the regiospecific construction of unsymmetrical biaryls is presented, in which easily available salts of carboxylic acids are decarboxylated…”
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Efficient Synthesis of the Structural Core of Tetracyclines by a Palladium-Catalyzed Domino Tsuji-Trost-Heck-Mizoroki Reaction by Tietze, Lutz F., Redert, Thomas, Bell, Hubertus P., Hellkamp, Sascha, Levy, Laura M.

“…The Pd‐catalyzed domino Tsuji–Trost–Heck–Mizoroki reactions of compounds 18, 27, and 34, respectively, each containing an allyl acetate and a halogen aryl…”
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Fragment-Based Interrogation of the 14–3–3/TAZ Protein–Protein Interaction by Andlovic, Blaž, Valenti, Dario, Centorrino, Federica, Picarazzi, Francesca, Hristeva, Stanimira, Hiltmann, Malgorzata, Wolf, Alexander, Cantrelle, François-Xavier, Mori, Mattia, Landrieu, Isabelle, Levy, Laura M., Klebl, Bert, Tzalis, Dimitrios, Genski, Thorsten, Eickhoff, Jan, Ottmann, Christian

“…The identification of chemical starting points for the development of molecular glues is challenging. Here, we employed fragment screening and identified an…”
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Set-up and screening of a fragment library targeting the 14-3-3 protein interface by Valenti, Dario, Neves, João Filipe, Cantrelle, François-Xavier, Hristeva, Stanimira, Lentini Santo, Domenico, Obšil, Tomáš, Hanoulle, Xavier, Levy, Laura M, Tzalis, Dimitrios, Landrieu, Isabelle, Ottmann, Christian

“…Protein-protein interactions (PPIs) are at the core of regulation mechanisms in biological systems and consequently became an attractive target for therapeutic…”
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Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering by Wolter, Madita, Valenti, Dario, Cossar, Peter J., Levy, Laura M., Hristeva, Stanimira, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian

“…Small‐molecule stabilization of protein–protein interactions (PPIs) is a promising concept in drug discovery, however the question how to identify or design…”
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5H-Furan-2-ones from fungal cultures of Aporpium caryae by LEVY, Laura M, CABRERA, Gabriela M, WRIGHT, Jorge E, SELDES, Alicia M

“…Four furanones 1-4 with an unusual skeleton containing an acetylene unit, named aporpinones, were isolated from the culture of the basidiomycete Aporpium…”
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Synthesis and Enzymatic Kinetic Resolution of α,α-Disubstituted Cyclic Hydroxy Nitriles by Levy, Laura M, Gotor, Vicente

“…Herein, we describe the diastereoselective synthesis of five- and six-membered α,α-disubstituted cyclic β-hydroxy nitriles and their resolution via enzymatic…”
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Resolution of N-protected cis- and trans-3-aminocyclohexanols via lipase-catalyzed enantioselective acylation in organic media by Levy, Laura M., de Gonzalo, Gonzalo, Gotor, Vicente

“…Graphic The enzymatic acylation of N-protected cis-and trans-1,3-aminocyclohexanols using lipases in organic solvents is described. By modifying certain…”
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Analysis of variability in vertebral morphology and growth ring counts in two Carcharhinid sharks by Piercy, Andrew N, d, Travis S, Levy, Laura M, Snelson, Franklin F

“…Inter- and intra-regional variations in vertebrae morphology and growth increment counts (band counts) were analyzed for two carcharhinid shark species,…”
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Characterisation of fungal lanostane-type triterpene acids by electrospray ionisation mass spectrometry by Cabrera, Gabriela M, Vellasco, Adriana P, Levy, Laura M, Eberlin, Marcos N

“…Lanostane-triterpene acids obtained from the culture of the fungus Coriolellus malicola were studied by electrospray mass spectrometry in the negative ion mode…”
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Indole alkaloids from a culture of the fungus Aporpium caryae by Levy, Laura M, Cabrera, Gabriela M, Wright, Jorge E, Seldes, Alicia M

“…In a screening for antifungal metabolites, two indole compounds of mixed biogenesis, 1H-indole-3-carboxylic acid, 1-(1,1-dimethyl-2-propenyl) methyl ester and…”
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Set-up and screening of a fragment library targeting the 14-3-3 protein interface† †Electronic supplementary information (ESI) available: Statistical analysis of the fragment collection, DSF melting curves, DSF compound-induced thermal shifts, WaterLOGSY NMR spectra, 1H–15N TROSY-HSQC NMR spectra and chemical shift perturbation plots. See DOI: 10.1039/c9md00215d by Valenti, Dario, Neves, João Filipe, Cantrelle, François-Xavier, Hristeva, Stanimira, Lentini Santo, Domenico, Obšil, Tomáš, Hanoulle, Xavier, Levy, Laura M., Tzalis, Dimitrios, Landrieu, Isabelle, Ottmann, Christian

“…Fragment-based driven discovery of 3 new low molecular weight starting points for the modulation of 14-3-3 protein–protein interactions. Protein–protein…”
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Lipase-catalysed resolution of cyclic cis- and trans-β-hydroxy esters by Levy, Laura M., Dehli, Juan R., Gotor, Vicente

“…Lipases A and B from Candida antarctica are shown to be highly efficient and complementary biocatalysts for the resolution of five- to seven-membered cyclic…”
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Analysis of variability in vertebral morphology and growth ring counts in two Carcharhinid sharks: Age and Growth of Chondrichthyan Fishes: New Methods, Techniques and Analysis by PIERCY, Andrew N, FORD, Travis S, LEVY, Laura M, SNELSON, Franklin F

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5 H-Furan-2-ones from fungal cultures of Aporpium caryae by Levy, Laura M, Cabrera, Gabriela M, Wright, Jorge E, Seldes, Alicia M

“…Four furanones 1– 4 with an unusual skeleton containing an acetylene unit, named aporpinones, were isolated from the culture of the basidiomycete Aporpium…”
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