Search Results - "Levy, David E."

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling by Gough, Daniel J., Messina, Nicole L., Clarke, Christopher J.P., Johnstone, Ricky W., Levy, David E.

“…Interferons (IFNs) were discovered as cytokines induced during and protecting from viral infection. They have been documented to play essential roles in…”
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The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation by Gough, Daniel J, Koetz, Lisa, Levy, David E

“…Activating mutations in the RasGTPases are the most common oncogenic lesions in human cancer. Similarly, elevated STAT3 expression and/or phosphorylation are…”
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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation by Gough, Daniel J, Corlett, Alicia, Schlessinger, Karni, Wegrzyn, Joanna, Larner, Andrew C, Levy, David E

“…Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor responsive to cytokine signaling and tyrosine kinase…”
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STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis by CORCORAN, Ryan B, CONTINO, Gianmarco, DESHPANDE, Vikram, TZATSOS, Alexandros, CONRAD, Claudius, BENES, Cyril H, LEVY, David E, SETTLEMAN, Jeffrey, ENGELMAN, Jeffrey A, BARDEESY, Nabeel

“…The STAT3 transcription factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflammation. In the pancreas, STAT3 is…”
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STAT3 negatively regulates type I IFN-mediated antiviral response by Wang, Wei-Bei, Levy, David E, Lee, Chien-Kuo

“…Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling through type I IFN receptors triggers the activation of STAT…”
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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways by Zhou, Liang, Ivanov, Ivaylo I, Spolski, Rosanne, Min, Roy, Shenderov, Kevin, Egawa, Takeshi, Levy, David E, Leonard, Warren J, Littman, Dan R

“…T helper cells that produce interleukin 17 (IL-17; 'T(H)-17 cells') are a distinct subset of proinflammatory cells whose in vivo function requires IL-23 but…”
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Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells by Genini, Davide, Brambilla, Lara, Laurini, Erik, Merulla, Jessica, Civenni, Gianluca, Pandit, Shusil, D’Antuono, Rocco, Perez, Laurent, Levy, David E., Pricl, Sabrina, Carbone, Giuseppina M., Catapano, Carlo V.

“…In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of…”
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A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells by Littman, Dan R, Manel, Nicolas, Hogstad, Brandon, Wang, Yaming, Levy, David E, Unutmaz, Derya

“…Dendritic cells serve a key function in host defence, linking innate detection of microbes to activation of pathogen-specific adaptive immune responses…”
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PKR Transduces MDA5-Dependent Signals for Type I IFN Induction by Pham, Alissa M, Santa Maria, Felicia Gilfoy, Lahiri, Tanaya, Friedman, Eugene, Marié, Isabelle J, Levy, David E

“…Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type…”
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Induction and function of type I and III interferon in response to viral infection by Levy, David E, Marié, Isabelle J, Durbin, Joan E

“…► Viral infection induces type I and III IFN through recognition of viral nucleic acid. ► Ubiquitin is a key signaling component downstream of nucleic acid…”
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Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer by Lahiri, Tanaya, Brambilla, Lara, Andrade, Joshua, Askenazi, Manor, Ueberheide, Beatrix, Levy, David E.

“…Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with roles in inflammation and tumorigenicity. A fraction of STAT3…”
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Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells by Mathur, Anubhav N, Chang, Hua-Chen, Zisoulis, Dimitrios G, Stritesky, Gretta L, Yu, Qing, O'Malley, John T, Kapur, Reuben, Levy, David E, Kansas, Geoffrey S, Kaplan, Mark H

“…IL-17-secreting CD4(+) T cells are critically involved in inflammatory immune responses. Development of these cells is promoted in vivo and in vitro by IL-23…”
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The molecular basis of IL-21–mediated proliferation by Zeng, Rong, Spolski, Rosanne, Casas, Esther, Zhu, Wei, Levy, David E., Leonard, Warren J.

“…Interleukin-21 (IL-21) is a type I cytokine that modulates functions of T, B, natural killer (NK), and myeloid cells. The IL-21 receptor (IL-21R) is closely…”
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STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation by Gough, Daniel J., Marié, Isabelle J., Lobry, Camille, Aifantis, Iannis, Levy, David E.

“…Juvenile myelomonocytic leukemia, acute myeloid leukemia (AML), and other myeloproliferative neoplasms (MPNs) are genetically heterogeneous but frequently…”
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IL-21 Mediates Suppressive Effects via Its Induction of IL-10 by Spolski, Rosanne, Kim, Hyoung-Pyo, Zhu, Wei, Levy, David E, Leonard, Warren J

“…IL-21 is a pleiotropic cytokine that is required for normal Ig production. We previously showed that IL-21 was elevated in BXSB-Yaa mice with systemic lupus…”
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Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors by Kwon, Hyokjoon, Thierry-Mieg, Danielle, Thierry-Mieg, Jean, Kim, Hyoung-Pyo, Oh, Jangsuk, Tunyaplin, Chainarong, Carotta, Sebastian, Donovan, Colleen E., Goldman, Matthew L., Tailor, Prafullakumar, Ozato, Keiko, Levy, David E., Nutt, Stephen L., Calame, Kathryn, Leonard, Warren J.

“…Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell…”
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JAK-STAT Signaling: From Interferons to Cytokines by Schindler, Christian, Levy, David E., Decker, Thomas

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway by de la Iglesia, Núria, Konopka, Genevieve, Puram, Sidharth V, Chan, Jennifer A, Bachoo, Robert M, You, Mingjian J, Levy, David E, Depinho, Ronald A, Bonni, Azad

“…Activation of the transcription factor STAT3 is thought to potently promote oncogenesis in a variety of tissues, leading to intense efforts to develop STAT3…”
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c-Maf Regulates IL-10 Expression during Th17 Polarization by Xu, Jiangnan, Yang, Yu, Qiu, Guixing, Lal, Girdhari, Wu, Zhihong, Levy, David E, Ochando, Jordi C, Bromberg, Jonathan S, Ding, Yaozhong

“…IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double-deficient Th17…”
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A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3 by Garama, Daniel J., Harris, Tiffany J., White, Christine L., Rossello, Fernando J., Abdul-Hay, Maher, Gough, Daniel J., Levy, David E.

“…Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation…”
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