Search Results - "Levy, Daniel L"
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Nuclear Size Scaling during Xenopus Early Development Contributes to Midblastula Transition Timing
Published in Current biology (05-01-2015)“…Early Xenopus laevis embryogenesis is a robust system for investigating mechanisms of developmental timing. After a series of rapid cell divisions with…”
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Mechanisms of Intracellular Scaling
Published in Annual review of cell and developmental biology (01-01-2012)“…Cell size varies widely among different organisms as well as within the same organism in different tissue types and during development, which places variable…”
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3
Sizing and shaping the nucleus: mechanisms and significance
Published in Current opinion in cell biology (01-06-2014)“…Highlights • Mechanisms of nuclear size and shape regulation. • Cell cycle events that influence nuclear morphology. • Nuclear morphology, chromatin…”
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4
Biological Scaling Problems and Solutions in Amphibians
Published in Cold Spring Harbor perspectives in biology (01-01-2016)“…Size is a primary feature of biological systems that varies at many levels, from the organism to its constituent cells and subcellular structures. Amphibians…”
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Both Nuclear Size and DNA Amount Contribute to Midblastula Transition Timing in Xenopus laevis
Published in Scientific reports (11-08-2017)“…During early Xenopus laevis embryogenesis both nuclear and cell volumes decrease with the nuclear-to-cytoplasmic (N/C) volume ratio reaching a maximum at the…”
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Protein kinase C activity modulates nuclear Lamin A/C dynamics in HeLa cells
Published in Scientific reports (16-03-2024)“…The nuclear lamina serves important functions in the nucleus, providing structural support to the nuclear envelope and contributing to chromatin organization…”
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The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos
Published in Developmental cell (10-08-2020)“…Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is…”
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Identification of epigenetic modulators as determinants of nuclear size and shape
Published in eLife (23-05-2023)“…The shape and size of the human cell nucleus is highly variable among cell types and tissues. Changes in nuclear morphology are associated with disease,…”
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Nuclear size regulation: from single cells to development and disease
Published in Trends in cell biology (01-04-2013)“…Cell size varies greatly among different cell types and organisms, especially during early development when cell division is rapid with little overall growth…”
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PKC-mediated phosphorylation of nuclear lamins at a single serine residue regulates interphase nuclear size in Xenopus and mammalian cells
Published in Molecular biology of the cell (15-05-2017)“…How nuclear size is regulated is a fundamental cell-biological question with relevance to cancers, which often exhibit enlarged nuclei. We previously reported…”
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11
Altering the levels of nuclear import factors in early Xenopus laevis embryos affects later development
Published in PloS one (22-04-2019)“…More than just a container for DNA, the nuclear envelope carries out a wide variety of critical and highly regulated cellular functions. One of these functions…”
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12
Porous-Coated Metaphyseal Sleeves for Severe Femoral and Tibial Bone Loss in Revision TKA
Published in The Journal of arthroplasty (01-11-2017)“…Abstract Background Metaphyseal bone loss is commonly encountered in revision total knee arthroplasty (TKA). Anderson Orthopaedic Research Institute (AORI)…”
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Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding
Published in Journal of cell science (15-03-2016)“…Altered nuclear size is associated with many cancers, and determining whether cancer-associated changes in nuclear size contribute to carcinogenesis…”
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Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression
Published in Scientific reports (08-12-2021)“…While changes in nuclear structure and organization are frequently observed in cancer cells, relatively little is known about how nuclear architecture impacts…”
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15
Editorial: Nuclear morphology in development and disease
Published in Frontiers in cell and developmental biology (08-08-2023)Get full text
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16
The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity
Published in EMBO reports (01-06-2019)Get full text
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17
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae Telomeres Regulates Telomere Length
Published in Molecular and Cellular Biology (01-12-2004)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of organelle size and organization during development
Published in Seminars in cell & developmental biology (15-01-2023)“…During early embryogenesis, as cells divide in the developing embryo, the size of intracellular organelles generally decreases to scale with the decrease in…”
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Nuclear Size Is Regulated by Importin α and Ntf2 in Xenopus
Published in Cell (15-10-2010)“…The size of the nucleus varies among different cell types, species, and disease states, but mechanisms of nuclear size regulation are poorly understood. We…”
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Nuclear F-actin and Lamin A antagonistically modulate nuclear shape
Published in Journal of cell science (01-07-2022)“…Nuclear shape influences cell migration, gene expression and cell cycle progression, and is altered in disease states like laminopathies and cancer. What…”
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