Search Results - "Levy, Dan D"

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs) by MacGregor, James T., Frötschl, Roland, White, Paul A., Crump, Kenny S., Eastmond, David A., Fukushima, Shoji, Guérard, Melanie, Hayashi, Makoto, Soeteman-Hernández, Lya G., Kasamatsu, Toshio, Levy, Dan D., Morita, Takeshi, Müller, Lutz, Schoeny, Rita, Schuler, Maik J., Thybaud, Véronique, Johnson, George E.

“…•An international working group report is presented.•Recommendations for quantitative assessment of genotoxic risk are summarized.•Methods of exposure–response…”
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A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals by Kirkland, David, Levy, Dan D., LeBaron, Matthew J., Aardema, Marilyn J., Beevers, Carol, Bhalli, Javed, Douglas, George R., Escobar, Patricia A., Farabaugh, Christopher S., Guerard, Melanie, Johnson, George E., Kulkarni, Rohan, Le Curieux, Frank, Long, Alexandra S., Lott, Jasmin, Lovell, David P., Luijten, Mirjam, Marchetti, Francesco, Nicolette, John J., Pfuhler, Stefan, Roberts, Daniel J., Stankowski, Leon F., Thybaud, Veronique, Weiner, Sandy K., Williams, Andrew, Witt, Kristine L., Young, Robert

“…•In vivo comet assay compared with transgenic rodent assay for 91 chemicals.•Comparison focussed on evaluation of in vivo genotoxicity per se.•Fair to good…”
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Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines by Thybaud, Veronique, Lorge, Elisabeth, Levy, Dan D., Benthem, Jan, Douglas, George R., Marchetti, Francesco, Moore, Martha M., Schoeny, Rita, Gibbons, Catherine

“…The Organization for Economic Cooperation and Development (OECD) recently revised the test guidelines (TGs) for genetic toxicology. This article describes the…”
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Microarray Analysis of Microbial Virulence Factors by CHIZHIKOV, Vladimir, RASOOLY, Avraham, CHUMAKOV, Konstantin, LEVY, Dan D

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Methyleugenol genotoxicity in the Fischer 344 rat using the comet assay and pathway-focused gene expression profiling by Ding, Wei, Levy, Dan D, Bishop, Michelle E, Lyn-Cook Lascelles, E, Kulkarni, Rohan, Chang, Ching-We, Aidoo, Anane, Manjanatha, Mugimane G

“…Methyleugenol (MEG), a constituent of human food, induces malignant tumors in multiple tissues of rats and mice. Although MEG forms DNA adducts and induces…”
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Current and Future Application of Genetic Toxicity Assays: The Role and Value of In Vitro Mammalian Assays by Elespuru, Rosalie K., Agarwal, Rajiv, Atrakchi, Aisar H., Bigger, C. Anita H., Heflich, Robert H., Jagannath, Devaraya R., Levy, Dan D., Moore, Martha M., Ouyang, Yanli, Robison, Timothy W., Sotomayor, Rene E., Cimino, Michael C., Dearfield, Kerry L.

“…With the advent of new technologies (e.g., genomics, automated analyses, and in vivo monitoring), new regulations (e.g., the reduction of animal tests by the…”
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Recommended criteria for the evaluation of bacterial mutagenicity data (Ames test) by Levy, Dan D., Zeiger, Errol, Escobar, Patricia A., Hakura, Atsushi, van der Leede, Bas-jan M., Kato, Masayuki, Moore, Martha M., Sugiyama, Kei-ichi

“…•Identification of factors to be considered when evaluating Ames test data.•The relative strengths and weaknesses of currently used evaluation criteria.•The…”
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Carcinogenicity of aspartame, methyleugenol, and isoeugenol by Riboli, Elio, Beland, Frederick A, Lachenmeier, Dirk W, Marques, M Matilde, Phillips, David H, Schernhammer, Eva, Afghan, Abdul, Assunção, Ricardo, Caderni, Giovanna, Corton, J Christopher, de Aragão Umbuzeiro, Gisela, de Jong, Daphne, Deschasaux-Tanguy, Melanie, Hodge, Allison, Ishihara, Junko, Levy, Dan D, Mandrioli, Daniele, McCullough, Marjorie L, McNaughton, Sarah A, Morita, Takeshi, Nugent, Anne P, Ogawa, Kumiko, Pandiri, Arun R, Sergi, Consolato M, Touvier, Mathilde, Zhang, Luoping, Benbrahim-Tallaa, Lamia, Chittiboyina, Shirisha, Cuomo, Danila, DeBono, Nathan L, Debras, Charlotte, de Conti, Aline, El Ghissassi, Fatiha, Fontvieille, Emma, Harewood, Rhea, Kaldor, John, Mattock, Heidi, Pasqual, Elisa, Rigutto, Gabrielle, Simba, Hannah, Suonio, Eero, Viegas, Susana, Wedekind, Roland, Schubauer-Berigan, Mary K, Madia, Federica

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Single-Nucleotide Polymorphism Mutation Spectra and Resistance to Quinolones in Salmonella enterica Serovar Enteritidis with a Mutator Phenotype by LEVY, Dan D, SHARMA, Bhavana, CEBULA, Thomas A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The science and regulations of probiotic food and supplement product labeling by Sanders, Mary Ellen, Levy, Dan D.

“…Presented by the New York Academy of Sciences, the U.S. Food and Drug Administration (FDA), and the U.S. Office of Dietary Supplements of the National…”
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Demonstrating laboratory proficiency in bacterial mutagenicity assays for regulatory submission by Levy, Dan D., Hakura, Atsushi, Elespuru, Rosalie K., Escobar, Patricia A., Kato, Masayuki, Lott, Jasmin, Moore, Martha M., Sugiyama, Kei-ichi

“…•Recommendations to achieve Ames test proficiency for regulatory submissions.•Learn the biological factors underling key steps in the test protocol.•Optimize…”
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Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT) by Speit, Günter, Kojima, Hajime, Burlinson, Brian, Collins, Andrew R., Kasper, Peter, Plappert-Helbig, Ulla, Uno, Yoshifumi, Vasquez, Marie, Beevers, Carol, De Boeck, Marlies, Escobar, Patricia A., Kitamoto, Sachiko, Pant, Kamala, Pfuhler, Stefan, Tanaka, Jin, Levy, Dan D.

“…•The in vivo comet assay is a mature test for the evaluation of genotoxicity.•Recommendations for an appropriate use of the assay are given.•Laboratories…”
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William Gary Flamm (1935–2017) by Green, Sidney, Levy, Dan D., Lorentzen, Ronald J., Zeiger, Errol, Gollapudi, B.

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Revisiting the bacterial mutagenicity assays: Report by a workgroup of the International Workshops on Genotoxicity Testing (IWGT) by Schoeny, Rita, Cross, Kevin P., DeMarini, David M., Elespuru, Rosalie, Hakura, Atsushi, Levy, Dan D., Williams, Richard V., Zeiger, Errol, Escobar, Patricia A., Howe, Jonathan R., Kato, Masayuki, Lott, Jasmin, Moore, Martha M., Simon, Stephanie, Stankowski, Leon F., Sugiyama, Kei-ichi, van der Leede, Bas-jan M.

“…•International Workshop on Genotoxicity Testing met in 2017 to address OECD TG471.•Strains sub-group concluded that most mutagens would be detected with fewer…”
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Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus) by Galloway, Sheila, Lorge, Elisabeth, Aardema, Marilyn J., Eastmond, David, Fellows, Mick, Heflich, Robert, Kirkland, David, Levy, Dan D., Lynch, Anthony M., Marzin, Daniel, Morita, Takeshi, Schuler, Maik, Speit, Günter

“…The selection of maximum concentrations for in vitro mammalian cell genotoxicity assays was reviewed at the 5th International Workshop on Genotoxicity Testing…”
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Evaluation of the highest concentrations used in the in vitro chromosome aberrations assay by Brookmire, Lauren, Chen, James J., Levy, Dan D.

“…There is controversy over the highest concentration to which an article should be tested in in vitro mammalian cell assays of genetic toxicity. Until recently,…”
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IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk by MacGregor, James T., Frötschl, Roland, White, Paul A., Crump, Kenny S., Eastmond, David A., Fukushima, Shoji, Guérard, Melanie, Hayashi, Makoto, Soeteman-Hernández, Lya G., Johnson, George E., Kasamatsu, Toshio, Levy, Dan D., Morita, Takeshi, Müller, Lutz, Schoeny, Rita, Schuler, Maik J., Thybaud, Véronique

“…•The publication is a report of an international working group.•Approaches for quantitative assessment of genotoxic risk are recommended.•Extrapolation from…”
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Safety assessment of probiotics for human use by Sanders, Mary Ellen, Akkermans, Louis M.A., Haller, Dirk, Hammerman, Cathy, Heimbach, James T., Hörmannsperger, Gabriele, Huys, Geert

“…The safety of probiotics is tied to their intended use, which includes consideration of potential vulnerability of the consumer or patient, dose and duration…”
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In vivo genotoxicity of estragole in male F344 rats by Ding, Wei, Levy, Dan D., Bishop, Michelle E., Pearce, Mason G., Davis, Kelly J., Jeffrey, Alan M., Duan, Jian-Dong, Williams, Gary M., White, Gene A., Lyn-Cook, Lascelles E., Manjanatha, Mugimane G.

“…Estragole, a naturally occurring constituent of various herbs and spices, is a rodent liver carcinogen which requires bio‐activation. To further understand the…”
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Follow-up actions from positive results of in vitro genetic toxicity testing by Dearfield, Kerry L, Thybaud, Véronique, Cimino, Michael C, Custer, Laura, Czich, Andreas, Harvey, James S, Hester, Susan, Kim, James H, Kirkland, David, Levy, Dan D, Lorge, Elisabeth, Moore, Martha M, Ouédraogo-Arras, Gladys, Schuler, Maik, Suter, Willi, Sweder, Kevin, Tarlo, Kirk, van Benthem, Jan, van Goethem, Freddy, Witt, Kristine L

“…Appropriate follow-up actions and decisions are needed when evaluating and interpreting clear positive results obtained in the in vitro assays used in the…”
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