Search Results - "Levo, Michal"

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters by Sharon, Eilon, Kalma, Yael, Sharp, Ayala, Raveh-Sadka, Tali, Levo, Michal, Zeevi, Danny, Keren, Leeat, Yakhini, Zohar, Weinberger, Adina, Segal, Eran

“…Analyzing the effects of multiple promoter motifs on gene expression can be a laborious process. Sharon et al . present a high-throughput method to measure the…”
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Unraveling determinants of transcription factor binding outside the core binding site by Levo, Michal, Zalckvar, Einat, Sharon, Eilon, Dantas Machado, Ana Carolina, Kalma, Yael, Lotam-Pompan, Maya, Weinberger, Adina, Yakhini, Zohar, Rohs, Remo, Segal, Eran

“…Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of gene expression. Despite many advances in the…”
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Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation by Segal, Eran, Pilpel, Yitzhak, Shalem, Ophir, Dahan, Orna, Levo, Michal, Martinez, Maria Rodriguez, Furman, Itay

“…The state of the transcriptome reflects a balance between mRNA production and degradation. Yet how these two regulatory arms interact in shaping the kinetics…”
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In pursuit of design principles of regulatory sequences by Levo, Michal, Segal, Eran

“…Key Points Regulatory DNA sequences contain information on the timing and level at which different genes are expressed. An ongoing challenge is to uncover the…”
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Dynamic interplay between enhancer–promoter topology and gene activity by Chen, Hongtao, Levo, Michal, Barinov, Lev, Fujioka, Miki, Jaynes, James B., Gregor, Thomas

“…A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology…”
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Genome organization controls transcriptional dynamics during development by Batut, Philippe J, Bing, Xin Yang, Sisco, Zachary, Raimundo, João, Levo, Michal, Levine, Michael S

“…Past studies offer contradictory claims for the role of genome organization in the regulation of gene activity. Here, we show through high-resolution…”
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Rules of transcriptional bursting revealed by absolute quantification of nascent RNA in living fly embryos by Chen, Po-Ta, Zoller, Benjamin, Levo, Michal, Gregor, Thomas

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Transcriptional coupling of distant regulatory genes in living embryos by Levo, Michal, Raimundo, João, Bing, Xin Yang, Sisco, Zachary, Batut, Philippe J., Ryabichko, Sergey, Gregor, Thomas, Levine, Michael S.

“…The prevailing view of metazoan gene regulation is that individual genes are independently regulated by their own dedicated sets of transcriptional enhancers…”
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Incorporating nucleosomes into thermodynamic models of transcription regulation by Raveh-Sadka, Tali, Levo, Michal, Segal, Eran

“…Transcriptional control is central to many cellular processes, and, consequently, much effort has been devoted to understanding its underlying mechanisms. The…”
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Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels by Haroush, Netta, Levo, Michal, Wieschaus, Eric F, Gregor, Thomas

“…Transcription factor combinations play a key role in shaping cellular identity. However, the precise relationship between specific combinations and downstream…”
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Live Measurements of Transcriptional Bursting and Dynamic Gene Regulation in Early Fly Embryos by Chen, Po-Ta, Zoller, Benjamin, Levo, Michal, Gregor, Thomas

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Characterization of the Functional Relevance of Intranuclear Transcription Factor Aggregates in Living Fly Embryos by Munshi, Rahul, Levo, Michal, Wieschaus, Eric, Gregor, Thomas

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Systematic Investigation of Transcription Factor Activity in the Context of Chromatin Using Massively Parallel Binding and Expression Assays by Levo, Michal, Avnit-Sagi, Tali, Lotan-Pompan, Maya, Kalma, Yael, Weinberger, Adina, Yakhini, Zohar, Segal, Eran

“…Precise gene expression patterns are established by transcription factor (TFs) binding to regulatory sequences. While these events occur in the context of…”
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Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast by Raveh-Sadka, Tali, Levo, Michal, Shabi, Uri, Shany, Boaz, Keren, Leeat, Lotan-Pompan, Maya, Zeevi, Danny, Sharon, Eilon, Weinberger, Adina, Segal, Eran

“…Eran Segal and colleagues measure the promoter activities of 70 different constructed promoter variants and find that poly(dA:dT) tracts significantly affect…”
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Compensation for differences in gene copy number among yeast ribosomal proteins is encoded within their promoters by Zeevi, Danny, Sharon, Eilon, Lotan-Pompan, Maya, Lubling, Yaniv, Shipony, Zohar, Raveh-Sadka, Tali, Keren, Leeat, Levo, Michal, Weinberger, Adina, Segal, Eran

“…Coordinate regulation of ribosomal protein (RP) genes is key for controlling cell growth. In yeast, it is unclear how this regulation achieves the required…”
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Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise by Dadiani, Maya, van Dijk, David, Segal, Barak, Field, Yair, Ben-Artzi, Gil, Raveh-Sadka, Tali, Levo, Michal, Kaplow, Irene, Weinberger, Adina, Segal, Eran

“…Individual cells from a genetically identical population exhibit substantial variation in gene expression. A significant part of this variation is due to noise…”
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Corrigendum: Unraveling determinants of transcription factor binding outside the core binding site by Levo, Michal, Zalckvar, Einat, Sharon, Eilon, Dantas Machado, Ana Carolina, Kalma, Yael, Lotan-Pompan, Maya, Weinberger, Adina, Yakhini, Zohar, Rohs, Remo, Segal, Eran

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Behind the Scene of Transcriptional Control - How is Regulation Implemented at the Level of DNA Binding? by Levo, Michal

“…Gene expression regulation underlies basic biological dynamics as response of cells to different environments, the proper progression of development and…”
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Functional analysis of a gene locus in response to non-canonical combinations of transcription factors by Haroush, Netta, Levo, Michal, Wieschaus, Eric, Gregor, Thomas

“…Transcription factor combinations determine gene locus activity and thereby cell identity. However, the precise link between concentrations of such activating…”
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Gene activity fully predicts transcriptional bursting dynamics by Chen, Po-Ta, Levo, Michal, Zoller, Benjamin, Gregor, Thomas

“…Transcription commonly occurs in bursts, with alternating productive (ON) and quiescent (OFF) periods, governing mRNA production rates. Yet, how transcription…”
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