Search Results - "Levitzki, Alexander"

Tyrosine Kinase Inhibitors: Views of Selectivity, Sensitivity, and Clinical Performance by LEVITZKI, Alexander

“…With the manufacture of imatinib, researchers introduced tyrosine kinase inhibitors (TKIs) into the clinical setting in 2000 to treat cancers; approximately…”
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Tyrphostins and other tyrosine kinase inhibitors by Levitzki, Alexander, Mishani, Eyal

“…The development of tyrosine phosphorylation inhibitors has transformed the approach to cancer therapy and is likely to affect other fields of medicine. In…”
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Targeting the EGFR and the PKB pathway in cancer by Klein, Shoshana, Levitzki, Alexander

“…The EGFR and PKB pathways are frequently activated in cancer, so are prime targets for cancer therapy. To this end, new inhibitors are being tested. EGFR…”
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Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment by REUVENI, Hadas, FLASHNER-ABRAMSON, Efrat, STEINER, Lilach, MAKEDONSKI, Kirill, RENDUO SONG, SHIR, Alexei, HERLYN, Meenhard, BAR-ELI, Menashe, LEVITZKI, Alexander

“…Insulin receptor substrates 1 and 2 (IRS1/2) mediate mitogenic and antiapoptotic signaling from insulin-like growth factor 1 receptor (IGF-IR), insulin…”
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ROS, stress-activated kinases and stress signaling in cancer by Benhar, Moran, Engelberg, David, Levitzki, Alexander

“…Anticancer therapy is frequently efficient in early stages of the disease, whereas advanced tumors are usually resistant to the same treatments. The molecular…”
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Impact of the Anticancer Drug NT157 on Tyrosine Kinase Signaling Networks by Su, Shih-Ping, Flashner-Abramson, Efrat, Klein, Shoshana, Gal, Mor, Lee, Rachel S, Wu, Jianmin, Levitzki, Alexander, Daly, Roger J

“…The small-molecule drug NT157 has demonstrated promising efficacy in preclinical models of a number of different cancer types, reflecting activity against both…”
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Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF by Edinger, Nufar, Lebendiker, Mario, Klein, Shoshana, Zigler, Maya, Langut, Yael, Levitzki, Alexander

“…Selective delivery of drugs to tumor cells can increase potency and reduce toxicity. In this study, we describe a novel recombinant chimeric protein, dsRBEC,…”
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Information-theoretic analysis of phenotype changes in early stages of carcinogenesis by Remacle, F., Kravchenko-Balasha, Nataly, Levitzki, Alexander, Levine, R. D.

“…Cancer is a multistep process characterized by altered signal transduction, cell growth, and metabolism. To identify such processes in early carcinogenesis we…”
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Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells by GARCIA, Roy, BOWMAN, Tammy L, LAUDANO, Andy, GAZIT, Aviv, LEVITZKI, Alexander, KRAKER, Alan, JOVE, Richard, NIU GUILLIAN, HUA YU, MINTON, Sue, MURO-CACHO, Carlos A, COX, Charles E, FALCONE, Robert, FAIRCLOUGH, Rita, PARSONS, Sarah

“…Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor…”
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Tyrosine Kinase Inhibition: An Approach to Drug Development by Levitzki, Alexander, Gazit, Aviv

“…Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the immune system. Uncontrolled…”
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Cisplatin-induced activation of the EGF receptor by BENHAR, Moran, ENGELBERG, David, LEVITZKI, Alexander

“…Cisplatin (CDDP) is an efficient DNA-damaging antitumor agent employed for the treatment of various human cancers. CDDP activates nuclear as well as…”
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On a fundamental structure of gene networks in living cells by Kravchenko-Balasha, Nataly, Levitzki, Alexander, Goldstein, Andrew, Rotter, Varda, Gross, A., Remacle, F., Levine, R. D.

“…Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression in a variety of species, organs, and…”
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Heterogeneity of gene expression in murine squamous cell carcinoma development-the same tumor by different means by Cohen, Noam, Kravchenko-Balasha, Nataly, Klein, Shoshana, Levitzki, Alexander

“…Transformation is a complex process, involving many changes in the cell. In this work, we investigated the transcriptional changes that arose during the…”
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EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice by Shir, Alexei, Ogris, Manfred, Wagner, Ernst, Levitzki, Alexander

“…Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12-14 mo from the time of…”
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Enhanced ROS Production in Oncogenically Transformed Cells Potentiates c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Activation and Sensitization to Genotoxic Stress by Benhar, Moran, Dalyot, Idan, Engelberg, David, Levitzki, Alexander

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Development of New Insulin-like Growth Factor-1 Receptor Kinase Inhibitors Using Catechol Mimics by Blum, Galia, Gazit, Aviv, Levitzki, Alexander

“…Because insulin-like growth factor-1 (IGF-1) and its receptor play a pivotal role in many cancers, it is an attractive target for the design of inhibitors…”
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Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells by Catlett-Falcone, Robyn, Landowski, Terry H, Oshiro, Marc M, Turkson, James, Levitzki, Alexander, Savino, Rocco, Ciliberto, Gennaro, Moscinski, Lynn, Fernández-Luna, Jose Luis, Nuñez, Gabriel, Dalton, William S, Jove, Richard

“…Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family…”
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Anomalous features of EMT during keratinocyte transformation by Geiger, Tamar, Sabanay, Helena, Kravchenko-Balasha, Nataly, Geiger, Benjamin, Levitzki, Alexander

“…During the evolution of epithelial cancers, cells often lose their characteristic features and acquire a mesenchymal phenotype, in a process known as…”
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Shift from Apoptotic to Necrotic Cell Death during Human Papillomavirus-induced Transformation of Keratinocytes by Kravchenko-Balasha, Nataly, Mizrachy-Schwartz, Sarit, Klein, Shoshana, Levitzki, Alexander

“…Oncogenic transformation is a complex, multistep process, which goes through several stages before complete malignant transformation occurs. To identify early…”
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Substrate Competitive Inhibitors of IGF-1 Receptor Kinase by Blum, Galia, Gazit, Aviv, Levitzki, Alexander

“…IGF-1 and its receptor play a pivotal role in many cancers, and therefore, IGF-1R is an attractive target for the design of inhibitors. In this communication,…”
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