Search Results - "Levitt, Michael D."

Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values by Furne, Julie, Saeed, Aalia, Levitt, Michael D

“…Hydrogen sulfide is gaining acceptance as an endogenously produced modulator of tissue function. The present paradigm of H(2)S (diprotonated, gaseous form of…”
Get more information

Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy by Mineri, Rossana, Zeviani, Massimo, Rimoldi, Marco, Tiranti, Valeria, Viscomi, Carlo, Hildebrandt, Tatjana, D Levitt, Michael, Tiveron, Cecilia, Prelle, Alessandro, Fagiolari, Gigliola, Di Meo, Ivano

“…Ethylmalonic encephalopathy is an autosomal recessive, invariably fatal disorder characterized by early-onset encephalopathy, microangiopathy, chronic…”
Get full text

Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function by Linden, David R, Levitt, Michael D, Farrugia, Gianrico, Szurszewski, Joseph H

“…Hydrogen sulfide (H(2)S) has long been associated with the gastrointestinal tract, especially the bacteria-derived H(2)S present in flatus. Along with evidence…”
Get more information

Production of the gaseous signal molecule hydrogen sulfide in mouse tissues by Linden, David R, Sha, Lei, Mazzone, Amelia, Stoltz, Gary J, Bernard, Cheryl E, Furne, Julie K, Levitt, Michael D, Farrugia, Gianrico, Szurszewski, Joseph H

“…The gaseous molecule hydrogen sulfide (H₂S) has been proposed as an endogenous signal molecule and neuromodulator in mammals. Using a newly developed method,…”
Get full text

Erythrocyte aging as a mechanism of anemia and a biomarker of device thrombosis in continuous-flow left ventricular assist devices by Taimeh, Ziad, MD, Koene, Ryan J., MD, Furne, Julie, BS, Singal, Ashish, PhD, Eckman, Peter M., MD, Levitt, Michael D., MD, Pritzker, Marc R., MD

“…Background Blood trauma caused by continuous-flow left ventricular assist devices (CF-LVADs) has been associated with device thrombosis and anemia. Accurate in…”
Get full text

Stability of human methanogenic flora over 35 years and a review of insights obtained from breath methane measurements by Levitt, Michael D, Furne, Julie K, Kuskowski, Michael, Ruddy, John

“…Breath methane measurements reflect the in situ activity of the methanogenic colonic flora. Thirty-five years ago we found that 34% of healthy adult subjects…”
Get more information

Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements by Levitt, David G, Levitt, Michael D

“…Serum albumin concentration (CP) is a remarkably strong prognostic indicator of morbidity and mortality in both sick and seemingly healthy subjects…”
Get full text

Relationship Between GHb Concentration and Erythrocyte Survival Determined From Breath Carbon Monoxide Concentration by VIRTUE, Mark A, FURNE, Julie K, NUTTALL, Frank Q, LEVITT, Michael D

“…Relationship Between GHb Concentration and Erythrocyte Survival Determined From Breath Carbon Monoxide Concentration Mark A. Virtue , MD , Julie K. Furne , BS…”
Get full text

Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue by Levitt, Michael D, Abdel-Rehim, Mohamed Saber, Furne, Julie

“…Endogenously produced hydrogen sulfide is thought to function as an intracellular messenger. There is, however, little information on tissue concentrations of…”
Get more information

Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa by Furne, Julie, Springfield, John, Koenig, Thomas, DeMaster, Eugene, Levitt, Michael D

“…Colonic bacteria release large quantities of the highly toxic thiols hydrogen sulfide (H 2S) and methanethiol (CH 3SH). These gases rapidly permeate the…”
Get full text

Association between fecal hydrogen sulfide production and pouchitis by OHGE, Hiroki, FUME, Julie K, SPRINGFIELD, John, ROTHENBERGER, David A, MADOFF, Robert D, LEVITT, Michael D

“…The beneficial effect of antibiotics in pouchitis suggests that an unidentified fecal bacterial product causes this condition. A candidate compound is hydrogen…”
Get full text

Quantitative modeling of the physiology of ascites in portal hypertension by Levitt, David G, Levitt, Michael D

“…Although the factors involved in cirrhotic ascites have been studied for a century, a number of observations are not understood, including the action of…”
Get full text

Quantitative Evaluation of D-Lactate Pathophysiology: New Insights into the Mechanisms Involved and the Many Areas in Need of Further Investigation by Levitt, Michael D, Levitt, David G

“…In contrast to L-lactate, D-lactate is produced in minimal quantities by human cells, and the plasma D-lactate concentration normally is maintained at a…”
Get full text

Systematic Review: Effective Management Strategies for Lactose Intolerance by SHAUKAT, Aasma, LEVITT, Michael D, TAYLOR, Brent C, MACDONALD, Roderick, SHAMLIYAN, Tatyana A, KANE, Robert L, WILT, Timothy J

“…Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear. To assess the…”
Get full text

Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source by Levitt, David G., Levitt, Michael D., Levitt, Joseph E.

“…Blood lactate concentration predicts mortality in critically ill patients and is clinically used in the diagnosis, grading of severity, and monitoring response…”
Get full text

Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states by Levitt, David G, Levitt, Michael D

“…Protein losing enteropathy (PLE) has been associated with more than 60 different conditions, including nearly all gastrointestinal diseases (Crohn's disease,…”
Get full text

Use of Breath Carbon Monoxide to Measure the Influence of Prosthetic Heart Valves on Erythrocyte Survival by Mitlyng, Benjamin L., Chandrashekhar, Yellapragada, Furne, Julie K., Levitt, Michael D.

“…First-generation prosthetic heart valves commonly caused sufficient red blood cell (RBC) injury to induce hemolytic anemia. Although multiple studies have…”
Get full text

A model of blood-ammonia homeostasis based on a quantitative analysis of nitrogen metabolism in the multiple organs involved in the production, catabolism, and excretion of ammonia in humans by Levitt, David G, Levitt, Michael D

“…Increased blood ammonia (NH ) is an important causative factor in hepatic encephalopathy, and clinical treatment of hepatic encephalopathy is focused on…”
Get full text

Gas production in humans ingesting a soybean flour derived from beans naturally low in oligosaccharides by Suarez, Fabrizis L, Springfield, John, Furne, Julie K, Lohrmann, Troy T, Kerr, Phillip S, Levitt, Michael D

“…Ingestion of soy products may cause excessive intestinal gas. This gas results from colonic bacterial fermentation of the indigestible oligosaccharides…”
Get full text

Alkaline Phosphatase Pathophysiology with Emphasis on the Seldom-Discussed Role of Defective Elimination in Unexplained Elevations of Serum ALP - A Case Report and Literature Review by Levitt, Michael D, Hapak, Sophie M, Levitt, David G

“…While serum alkaline phosphatase activity has become a routine clinical measurement, we have found that physicians' knowledge of the pathophysiology of this…”
Get full text