Search Results - "Levison, Steven W"

The role of inflammation in perinatal brain injury by Hagberg, Henrik, Mallard, Carina, Ferriero, Donna M., Vannucci, Susan J., Levison, Steven W., Vexler, Zinaida S., Gressens, Pierre

“…Key Points Perinatal brain injuries result from a spectrum of conditions, including neonatal encephalopathy, arterial ischaemic stroke, prematurity, and…”
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Delayed ALK5 inhibition improves functional recovery in neonatal brain injury by Guardia Clausi, Mariano, Levison, Steven W

“…Neuroinflammation subsequent to developmental brain injury contributes to a wave of secondary neurodegeneration and to reactive astrogliosis that can inhibit…”
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Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation by Tyler, William A, Gangoli, Nitish, Gokina, Pradeepa, Kim, Haesun A, Covey, Matthew, Levison, Steven W, Wood, Teresa L

“…Although both extrinsic and intrinsic factors have been identified that orchestrate the differentiation and maturation of oligodendrocytes, less is known about…”
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Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation by Kichev, Anton, Rousset, Catherine I., Baburamani, Ana A., Levison, Steven W., Wood, Teresa L., Gressens, Pierre, Thornton, Claire, Hagberg, Henrik

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family. The interaction of TRAIL with death receptor 4 (DR4) and DR5 can…”
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Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy by KRADY, J. Kyle, BASU, Anirban, ALLEN, Colleen M, YUPING XU, LANOUE, Kathryn F, GARDNER, Thomas W, LEVISON, Steven W

“…Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy J. Kyle…”
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Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum by Yang, Zhengang, You, Yan, Levison, Steven W.

“…Ischemia‐induced striatal neurogenesis from progenitors in the adjacent subventricular zone (SVZ) in young and adult rodents has been reported. However, it has…”
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Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine by Ziegler, Amber N., Feng, Qiang, Chidambaram, Shravanthi, Testai, Jaimie M., Kumari, Ekta, Rothbard, Deborah E., Constancia, Miguel, Sandovici, Ionel, Cominski, Tara, Pang, Kevin, Gao, Nan, Wood, Teresa L., Levison, Steven W.

“…Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are…”
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Interleukin-1: A master regulator of neuroinflammation by Basu, Anirban, Krady, J. Kyle, Levison, Steven W.

“…Interleukins 1α and 1β (IL‐1) are very potent signaling molecules that are expressed normally at low levels, but are induced rapidly in response to local or…”
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IGF-II Promotes Stemness of Neural Restricted Precursors by Ziegler, Amber N., Schneider, Joel S., Qin, Mei, Tyler, William A., Pintar, John E., Fraidenraich, Diego, Wood, Teresa L., Levison, Steven W.

“…Insulin‐like growth factor (IGF)‐I and IGF‐II regulate brain development and growth through the IGF type 1 receptor (IGF‐1R). Less appreciated is that IGF‐II,…”
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Neural Stem Cells in Adult Mammals are not Astrocytes by Velloso, Fernando Janczur, Shankar, Sandhya, Parpura, Vladimir, Rakic, Pasko, Levison, Steven W.

“…At the turn of the 21st century studies of the cells that resided in the adult mammalian subventricular zone (SVZ) characterized the neural stem cells (NSCs)…”
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Leukemia Inhibitory Factor Is Required for Subventricular Zone Astrocyte Progenitor Proliferation and for Prokineticin-2 Production after a Closed Head Injury in Mice by Frondelli, Michelle J, Levison, Steven W

“…Astrogliosis is one of the hallmarks of brain injury, and after a mild injury activated astrocytes subserve neuroprotective and pro-regenerative functions. We…”
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Olig1 is required for noggin‐induced neonatal myelin repair by Sabo, Jennifer K., Heine, Vivi, Silbereis, John C., Schirmer, Lucas, Levison, Steven W., Rowitch, David H.

“…Objective Neonatal white matter injury (NWMI) is a lesion found in preterm infants that can lead to cerebral palsy. Although antagonists of bone morphogenetic…”
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Moderately Inducing Autophagy Reduces Tertiary Brain Injury after Perinatal Hypoxia-Ischemia by Kim, Brian H, Jeziorek, Maciej, Kanal, Hur Dolunay, Contu, Viorica Raluca, Dobrowolski, Radek, Levison, Steven W

“…Recent studies of cerebral hypoxia-ischemia (HI) have highlighted slowly progressive neurodegeneration whose mechanisms remain elusive, but if blocked, could…”
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Intranasal Leukemia Inhibitory Factor Attenuates Gliosis and Axonal Injury and Improves Sensorimotor Function After a Mild Pediatric Traumatic Brain Injury by D'Mello, Veera, Subramaniam, Malini, Bhalla, Aditya Paul, Saavedra, Sherlyn, Leiba, Ofri, Levison, Steven W

“…Leukemia inhibitory factor (LIF) is a neuroprotective cytokine that is essential for appropriate glial responses, remyelination, and preservation of neuronal…”
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Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury by Yang, Zhengang, Covey, Matthew V., Bitel, Claudine L., Ni, Li, Jonakait, G. Miller, Levison, Steven W.

“…Objective Neocortical neurons are sensitive to hypoxic‐ischemic (H‐I) injuries at term and their demise contributes to neurological disorders. Here we tested…”
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Neural Stem/Progenitor Cells Participate in the Regenerative Response to Perinatal Hypoxia/Ischemia by Felling, Ryan J, Snyder, Matthew J, Romanko, Michael J, Rothstein, Raymond P, Ziegler, Amber N, Yang, Zhengang, Givogri, Maria I, Bongarzone, Ernesto R, Levison, Steven W

“…Perinatal hypoxia/ischemia (H/I) is the leading cause of neurologic injury resulting from birth complications. Recent advances in critical care have…”
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Analyzing mouse neural stem cell and progenitor cell proliferation using EdU incorporation and multicolor flow cytometry by Velloso, Fernando Janczur, Kumari, Ekta, Buono, Krista D., Frondelli, Michelle J., Levison, Steven W.

“…This protocol describes an ex vivo approach to identify and quantify the proportions of proliferating neural stem cells and progenitors of the mouse…”
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Perinatal IL-1β-induced inflammation suppresses Tbr2+ intermediate progenitor cell proliferation in the developing hippocampus accompanied by long-term behavioral deficits by Veerasammy, Stephanie, Van Steenwinckel, Juliette, Le Charpentier, Tifenn, Seo, Joon Ho, Fleiss, Bobbi, Gressens, Pierre, Levison, Steven W.

“…Meta-analyses have revealed associations between the incidence of maternal infections during pregnancy, premature birth, smaller brain volumes, and subsequent…”
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Vascular Endothelial Growth Factors A and C are Induced in the SVZ Following Neonatal Hypoxia–Ischemia and Exert Different Effects on Neonatal Glial Progenitors by Bain, Jennifer M., Moore, Lisamarie, Ren, Zhihua, Simonishvili, Sophia, Levison, Steven W.

“…Episodes of neonatal hypoxia–ischemia (H-I) are strongly associated with cerebral palsy and a wide spectrum of other neurological deficits in children. Two key…”
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Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia by Simonishvili, Sopio, Jain, Mohit Raja, Li, Hong, Levison, Steven W, Wood, Teresa L

“…OPC (oligodendrocyte progenitor cell) death contributes significantly to the pathology and functional deficits following hypoxic-ischemic injury in the…”
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