Search Results - "Levine, Jedd"

Btm-3566, a Novel Activator of the Mitochondrial Stress Response Promotes Robust Therapeutic Responses in Vitro and In Vivo in Diffuse Large B-Cell Lymphoma by Schwarzer, Adrian, Oliveira, Matheus, Kleppa, Marc-Jens, Anantha, Andy, Cooper, Alan, Hannink, Mark, Hembrough, Todd, Levine, Jedd, Luther, Michael, Stocum, Michael, Liesa-Roig, Marc, Kostura, Matthew

“…Relapsed/refractory diffuse large B-cell lymphomas (r/r-DLBCL) are a therapeutic challenge, especially in patients not suitable for high dose chemotherapy,…”
Get full text

Development and validation of blood-based predictive biomarkers for response to PD-(L)-1 checkpoint inhibitors: Evidence of a universal systemic core of 3D immunogenetic profiling across multiple oncological indications by Akoulitchev, Alexandre, Hunter, Ewan, Santos, Francisco C., Dezfouli, Mehrnoush, Koutsothanasi, Christina, Salter, Matthew, Powell, Ryan, Dring, Ann, Egan, Benedict, Parnall, Matthew, Thacker, Morgan, Green, Jayne, Ramadass, Aroul, Ng, Serene, Lim, Chun Ren, Guiel, Thomas, Heaton, Robert, Levine, Jedd

“…e14525 Background: Unprecedented advantages in cancer treatments with immune checkpoint inhibitors (ICI) remain limited to a subset of patients, with high…”
Get full text

Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1 by Schwarzer, Adrian, Oliveira, Matheus, Kleppa, Marc-Jens, Slattery, Scott D, Anantha, Andy, Cooper, Alan, Hannink, Mark, Schambach, Axel, Dörrie, Anneke, Kotlyarov, Alexey, Gaestel, Matthias, Hembrough, Todd, Levine, Jedd, Luther, Michael, Stocum, Michael, Stiles, Linsey, Weinstock, David M, Liesa, Marc, Kostura, Matthew J

“…DLBCL are aggressive, rapidly proliferating tumors that critically depend on the ATF4-mediated integrated stress response (ISR) to adapt to stress caused by…”
Get full text

Abstract 45: BTM-3528 potently induces G1/G0 cell cycle arrest and is efficacious in preclinical models of diffuse large B-cell lymphoma by Kostura, Matthew, Levine, Jedd, Oza, Vibha, Cooper, Alan, Arguello, Meztli, White, Peter W., Ciblat, Stephane, Regina, Anthony, Bellavance, Edith, Brault, Martine, Siddiqui, Arshad, Luther, Michael

“…Abstract Aberrant regulation of cell cycle control, integration of signals from oncogenic signaling pathways, and cancer cell metabolism play a key role in the…”
Get full text

Economic impact and outcome benefits of integrating quantitative proteomics analysis to guide treatment strategies for metastatic breast cancer patients by Segall, Darron, Xenakis, Jason, Hertz, Deanna, Sellappan, Shankar, Blackler, Adele, Levine, Jedd, Rabizadeh, Shahrooz, Hembrough, Todd A.

“…Abstract only…”
Get full text

Development and Validation of Blood-Based Predictive Biomarkers for Response to PD-1/PD-L1 Checkpoint Inhibitors: Evidence of a Universal Systemic Core of 3D Immunogenetic Profiling across Multiple Oncological Indications by Hunter, Ewan, Salter, Matthew, Powell, Ryan, Dring, Ann, Naithani, Tarun, Chatziioannou, Maria Eleni, Gebregzabhar, Abel, Issa, Mutaz, Green, Jayne, Ng, Serene, Lim, Chun Ren, Keat, Cheah Soon, Suan, Ang Tick, Raman, Rakesh, Fatt, Ho Kean, Luen, Fabian Lee Wei, Alshaker, Heba, Pchejetski, Dmitri, Blum, Dave, Guiel, Thomas, Heaton, Jr, Robert, Levine, Jedd, Akoulitchev, Alexandre

“…Unprecedented advantages in cancer treatment with immune checkpoint inhibitors (ICIs) remain limited to only a subset of patients. Systemic analyses of the…”
Get full text

Chemotherapy of malignant thymoma. Case report and review of the literature by Hu, E, Levine, J

“…The authors report the case of a patient with malignant thymoma unresponsive to combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, and…”
Get more information

1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents by Cooper, Alan B., Ciblat, Stephane, Shipps, Gerald, Levine, Jedd, Kostura, Matthew, Oza, Vibha, Constantineau-Forget, Lea, Dery, Martin, Grand-Maitre, Chantal, Bruneau-Latour, Nicolas, Bellavance, Edith, Patane, Michael, Siddiqui, Arshad, Luther, Michael

“…[Display omitted] A class of substituted 1-thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives was found to have potent anti-proliferative…”
Get full text

Abstract PO-47: BTM-3566 induces complete tumor regression in diffuse large B-cell lymphoma: Regulation by the eIF2α kinase “heme-regulated inhibitor” and the mitochondrial protein FAM210B by Kostura, Matthew, Levine, Jedd, Cooper, Alan, Anantha, Andy, Stocum, Michael, Luther, Michael

“…Abstract BTM-3566 is a novel small-molecule compound with broad anticancer activity in hematologic and solid cancers, with exceptional activity against diffuse…”
Get full text

Abstract A07: BTM 3566, a novel activator of the mitochondrial stress response promotes robust therapeutic responses in vitro and in vivo in diffuse large B-cell lymphoma by Schwarzer, Adrian, Oliveira, Matheus, Kleppa, Marc-Jens, Anantha, Andy, Cooper, Alan, Hannink, Mark, Hembrough, Todd, Levine, Jedd, Luther, Michael, Stocum, Michael, Stiles, Linsey, Liesa-Roig, Marc, Kostura, Matthew

“…Abstract Relapsed/refractory diffuse large B-cell lymphomas (r/r-DLBCL) are a therapeutic challenge as they are highly heterogeneous both clinically and…”
Get full text

Abstract 3784: BTM-3655 co-opts mitochondrial quality control pathways to induce apoptosis, and complete tumor regression in DLBCL cell lines, xenografts and PDX models by Schwarzer, Adrian, Oliveira, Matheus, Kleppa, Marc-Jens, Anantha, Andy, Cooper, Alan, Hembrough, Todd, Levine, Jedd, Luther, Michael, Stocum, Michael, Liesa-Roig, Marc, Kostura, Matt

“…Abstract Cellular integrated stress response (ISR) pathways are induced by multiple triggers - viral RNA, nutrient deprivation, protein misfolding and…”
Get full text

Corrigendum to “1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents” [Bioorg. Med. Chem. Lett. 27 (2017) 4471–4477] by Cooper, Alan B., Ciblat, Stephane, Shipps, Gerald, Levine, Jedd, Kostura, Matthew, Oza, Vibha, Constantineau-Forget, Lea, Dery, Martin, Grand-Maitre, Chantal, Bruneau-Latour, Nicolas, Bellavance, Edith, Patane, Michael, Siddiqui, Arshad, Luther, Michael

Get full text

Clinical and Immunologic Effects of Recombinant Leukocyte A Interferon in Eight Patients With Advanced Cancer by Horning, Sandra J, Levine, Jedd F, Miller, Richard A, Rosenberg, Saul A, Merigan, Thomas C

“…The clinical and immunologic effects of a biosynthetic human leukocyte interferon, recombinant leukocyte A interferon (IFL-rA), are reported in eight patients…”
Get full text

3T3-L1 adipocytes promote the growth of mammary epithelium by Levine, J F, Stockdale, F E

“…Murine mammary epithelium grows in association with predominantly adipocyte stroma in vivo. To investigate potential growth-promoting effects of adipocytes on…”
Get more information

Cell-Cell Interactions Promote Mammary Epithelial Cell Differentiation by Levine, Jedd F., Stockdale, Frank E.

“…Mammary epithelium differentiates in a stromal milieu of adipocytes and fibroblasts. To investigate cell-cell interactions that may influence mammary…”
Get full text

The effect of postoperative and primary radiation therapy on delivered dose of adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy in breast cancer by Levine, J F, Coleman, C N, Cox, R S, Ray, G R, Rogoway, W M, Martinez, A, Stockdale, F E

“…The dose of adjuvant chemotherapy for breast cancer may be an important factor in the success of the treatment program. In a retrospective analysis, the…”
Get more information